Effect of specific antibodies on chronic echovirus type 5 encephalitis in a patient with hypogammaglobulinemia

L. S. Weiner, J. T. Howell, M. P. Langford, G. J. Stanton, S. Baron, R. M. Goldblum, R. A. Lord, A. S. Goldman

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

The effects of specific antibodies in chronic echovirus type 5 (echo 5) encephalitis were investigated in a patient with x-linked hypogammaglobulinemia. Virus was detected in cerebrospinal fluid (CSF) and blood despite treatment with commercial human gammaglobulin that contained low titers of antibodies to echo 5 (0.6 × 104 units per injection). Virus disappeared from blood and CSF when plasma containing high concentrations of antibodies (total dose, 1-4 × 104 units/kg) was administered intravenously. Maximal inhibition of virus was achieved in culture and in the patient’s CSF when the titer of antibody to echo 5 in CSF was ≥ 16 units/ml. Although the patient died, hyperimmune plasma improved the neurologic status and eliminated detectable virus from the blood and CSF.

Original languageEnglish (US)
Pages (from-to)858-863
Number of pages6
JournalJournal of Infectious Diseases
Volume140
Issue number6
DOIs
StatePublished - Dec 1979
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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