Effect of specific antibodies on chronic echovirus type 5 encephalitis in a patient with hypogammaglobulinemia

L. S. Weiner, J. T. Howell, M. P. Langford, G. J. Stanton, S. Baron, R. M. Goldblum, R. A. Lord, A. S. Goldman

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Abstract

The effects of specific antibodies in chronic echovirus type 5 (echo 5) encephalitis were investigated in a patient with x-linked hypogammaglobulinemia. Virus was detected in cerebrospinal fluid (CSF) and blood despite treatment with commercial human gammaglobulin that contained low titers of antibodies to echo 5 (0.6 x 10 4 units per injection). Virus disappeared from blood and CSF when plasma containing high concentrations of antibodies (total dose, 1-4 x 10 4 units/kg) was administered intravenously. Maximal inhibition of virus was achieved in culture and in the patient's CSF when the titer of antibody to echo 5 in CSF was ≥16 units/ml. Although the patient died, hyperimmune plasma improved the neurologic status and eliminated detectable virus from the blood and CSF.

Original languageEnglish (US)
Pages (from-to)858-863
Number of pages6
JournalJournal of Infectious Diseases
Volume140
Issue number6
StatePublished - 1979

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Human Enterovirus B
Agammaglobulinemia
Encephalitis
Cerebrospinal Fluid
Antibodies
Viruses
Nervous System
Injections

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Weiner, L. S., Howell, J. T., Langford, M. P., Stanton, G. J., Baron, S., Goldblum, R. M., ... Goldman, A. S. (1979). Effect of specific antibodies on chronic echovirus type 5 encephalitis in a patient with hypogammaglobulinemia. Journal of Infectious Diseases, 140(6), 858-863.

Effect of specific antibodies on chronic echovirus type 5 encephalitis in a patient with hypogammaglobulinemia. / Weiner, L. S.; Howell, J. T.; Langford, M. P.; Stanton, G. J.; Baron, S.; Goldblum, R. M.; Lord, R. A.; Goldman, A. S.

In: Journal of Infectious Diseases, Vol. 140, No. 6, 1979, p. 858-863.

Research output: Contribution to journalArticle

Weiner, LS, Howell, JT, Langford, MP, Stanton, GJ, Baron, S, Goldblum, RM, Lord, RA & Goldman, AS 1979, 'Effect of specific antibodies on chronic echovirus type 5 encephalitis in a patient with hypogammaglobulinemia', Journal of Infectious Diseases, vol. 140, no. 6, pp. 858-863.
Weiner LS, Howell JT, Langford MP, Stanton GJ, Baron S, Goldblum RM et al. Effect of specific antibodies on chronic echovirus type 5 encephalitis in a patient with hypogammaglobulinemia. Journal of Infectious Diseases. 1979;140(6):858-863.
Weiner, L. S. ; Howell, J. T. ; Langford, M. P. ; Stanton, G. J. ; Baron, S. ; Goldblum, R. M. ; Lord, R. A. ; Goldman, A. S. / Effect of specific antibodies on chronic echovirus type 5 encephalitis in a patient with hypogammaglobulinemia. In: Journal of Infectious Diseases. 1979 ; Vol. 140, No. 6. pp. 858-863.
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