Effect of stress, meal and neostigmine on rectosigmoid electrical control activity (ECA) in normals and in irritable bowel syndrome patients

Sushil Sarna, Paul Latimer, Dugal Campbell, W. E. Waterfall

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

An intraluminal probe with two sets of bipolar electrodes (4 cm apart) was used to record electrical control activity (ECA) from the rectosigmoid of 17 normal subjects and 16 IBS patients in the resting state, during neutral and stressful interviews, and after a meal or neostigmine. Fast Fourier transform method was used for the frequency analysis of ECA. The ECA was present at all times in both the groups but was variable in frequency and amplitude and was phase-unlocked during all recording periods. Up to four frequency components were observed in the lower frequency range (LFR) of 2.0-9.0 c/min and up to two in the higher frequency range (HFR) of 9.0-13.0 c/min during all recording periods. The frequency and organization of ECA were not significantly different between the normal and the IBS groups in the resting state. Neutral and stressful interviews did not significantly affect the mean ECA frequency in either of the groups but the mean ECA frequency of the dominant frequency component in LFR was lower in IBS patients than in the normal subjects during the stressful interview. Meal and neostigmine did not significantly affect the ECA frequency or its organization in either of the groups. It appears from this study that alterations in colonic ECA may not form the basis of motility disorder in irritable bowel syndrome.

Original languageEnglish (US)
Pages (from-to)582-591
Number of pages10
JournalDigestive Diseases and Sciences
Volume27
Issue number7
DOIs
StatePublished - Jul 1982
Externally publishedYes

Fingerprint

Neostigmine
Irritable Bowel Syndrome
Meals
Interviews
Fourier Analysis
Electrodes

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Effect of stress, meal and neostigmine on rectosigmoid electrical control activity (ECA) in normals and in irritable bowel syndrome patients. / Sarna, Sushil; Latimer, Paul; Campbell, Dugal; Waterfall, W. E.

In: Digestive Diseases and Sciences, Vol. 27, No. 7, 07.1982, p. 582-591.

Research output: Contribution to journalArticle

@article{abc8c9fde9f64471bf367c6803318ced,
title = "Effect of stress, meal and neostigmine on rectosigmoid electrical control activity (ECA) in normals and in irritable bowel syndrome patients",
abstract = "An intraluminal probe with two sets of bipolar electrodes (4 cm apart) was used to record electrical control activity (ECA) from the rectosigmoid of 17 normal subjects and 16 IBS patients in the resting state, during neutral and stressful interviews, and after a meal or neostigmine. Fast Fourier transform method was used for the frequency analysis of ECA. The ECA was present at all times in both the groups but was variable in frequency and amplitude and was phase-unlocked during all recording periods. Up to four frequency components were observed in the lower frequency range (LFR) of 2.0-9.0 c/min and up to two in the higher frequency range (HFR) of 9.0-13.0 c/min during all recording periods. The frequency and organization of ECA were not significantly different between the normal and the IBS groups in the resting state. Neutral and stressful interviews did not significantly affect the mean ECA frequency in either of the groups but the mean ECA frequency of the dominant frequency component in LFR was lower in IBS patients than in the normal subjects during the stressful interview. Meal and neostigmine did not significantly affect the ECA frequency or its organization in either of the groups. It appears from this study that alterations in colonic ECA may not form the basis of motility disorder in irritable bowel syndrome.",
author = "Sushil Sarna and Paul Latimer and Dugal Campbell and Waterfall, {W. E.}",
year = "1982",
month = "7",
doi = "10.1007/BF01297213",
language = "English (US)",
volume = "27",
pages = "582--591",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Springer New York",
number = "7",

}

TY - JOUR

T1 - Effect of stress, meal and neostigmine on rectosigmoid electrical control activity (ECA) in normals and in irritable bowel syndrome patients

AU - Sarna, Sushil

AU - Latimer, Paul

AU - Campbell, Dugal

AU - Waterfall, W. E.

PY - 1982/7

Y1 - 1982/7

N2 - An intraluminal probe with two sets of bipolar electrodes (4 cm apart) was used to record electrical control activity (ECA) from the rectosigmoid of 17 normal subjects and 16 IBS patients in the resting state, during neutral and stressful interviews, and after a meal or neostigmine. Fast Fourier transform method was used for the frequency analysis of ECA. The ECA was present at all times in both the groups but was variable in frequency and amplitude and was phase-unlocked during all recording periods. Up to four frequency components were observed in the lower frequency range (LFR) of 2.0-9.0 c/min and up to two in the higher frequency range (HFR) of 9.0-13.0 c/min during all recording periods. The frequency and organization of ECA were not significantly different between the normal and the IBS groups in the resting state. Neutral and stressful interviews did not significantly affect the mean ECA frequency in either of the groups but the mean ECA frequency of the dominant frequency component in LFR was lower in IBS patients than in the normal subjects during the stressful interview. Meal and neostigmine did not significantly affect the ECA frequency or its organization in either of the groups. It appears from this study that alterations in colonic ECA may not form the basis of motility disorder in irritable bowel syndrome.

AB - An intraluminal probe with two sets of bipolar electrodes (4 cm apart) was used to record electrical control activity (ECA) from the rectosigmoid of 17 normal subjects and 16 IBS patients in the resting state, during neutral and stressful interviews, and after a meal or neostigmine. Fast Fourier transform method was used for the frequency analysis of ECA. The ECA was present at all times in both the groups but was variable in frequency and amplitude and was phase-unlocked during all recording periods. Up to four frequency components were observed in the lower frequency range (LFR) of 2.0-9.0 c/min and up to two in the higher frequency range (HFR) of 9.0-13.0 c/min during all recording periods. The frequency and organization of ECA were not significantly different between the normal and the IBS groups in the resting state. Neutral and stressful interviews did not significantly affect the mean ECA frequency in either of the groups but the mean ECA frequency of the dominant frequency component in LFR was lower in IBS patients than in the normal subjects during the stressful interview. Meal and neostigmine did not significantly affect the ECA frequency or its organization in either of the groups. It appears from this study that alterations in colonic ECA may not form the basis of motility disorder in irritable bowel syndrome.

UR - http://www.scopus.com/inward/record.url?scp=0019955494&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019955494&partnerID=8YFLogxK

U2 - 10.1007/BF01297213

DO - 10.1007/BF01297213

M3 - Article

VL - 27

SP - 582

EP - 591

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

IS - 7

ER -