Effect of substance P on contractions of the gallbladder

L. Mate, T. Sakamoto, G. H. Greeley, J. C. Thompson

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The effect of substance P on contractions of the gallbladder in dogs (in vivo) and rabbits (in vitro) was examined. Substance P stimulated contraction of the gallbladder, both in vivo and in vitro; however, substance P was not as effective as cholecystokinin. Stimulation of gallbladder contractions in vivo by substance P was not affected by atropine. Stimulation of gallbladder strips in vitro by substance P was not affected by adrenergic antagonists or tetrodotoxin. These findings suggest that substance P may be a direct stimulant of contraction of the smooth muscle of the gallbladder.

Original languageEnglish (US)
Pages (from-to)163-166
Number of pages4
JournalSurgery Gynecology and Obstetrics
Volume163
Issue number2
StatePublished - 1986

Fingerprint

Substance P
Gallbladder
Adrenergic Antagonists
Cholecystokinin
Tetrodotoxin
Atropine
Smooth Muscle
Dogs
Rabbits
In Vitro Techniques

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Surgery

Cite this

Mate, L., Sakamoto, T., Greeley, G. H., & Thompson, J. C. (1986). Effect of substance P on contractions of the gallbladder. Surgery Gynecology and Obstetrics, 163(2), 163-166.

Effect of substance P on contractions of the gallbladder. / Mate, L.; Sakamoto, T.; Greeley, G. H.; Thompson, J. C.

In: Surgery Gynecology and Obstetrics, Vol. 163, No. 2, 1986, p. 163-166.

Research output: Contribution to journalArticle

Mate, L, Sakamoto, T, Greeley, GH & Thompson, JC 1986, 'Effect of substance P on contractions of the gallbladder', Surgery Gynecology and Obstetrics, vol. 163, no. 2, pp. 163-166.
Mate L, Sakamoto T, Greeley GH, Thompson JC. Effect of substance P on contractions of the gallbladder. Surgery Gynecology and Obstetrics. 1986;163(2):163-166.
Mate, L. ; Sakamoto, T. ; Greeley, G. H. ; Thompson, J. C. / Effect of substance P on contractions of the gallbladder. In: Surgery Gynecology and Obstetrics. 1986 ; Vol. 163, No. 2. pp. 163-166.
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