Abstract
The effect of substance P on contractions of the gallbladder in dogs (in vivo) and rabbits (in vitro) was examined. Substance P stimulated contraction of the gallbladder, both in vivo and in vitro; however, substance P was not as effective as cholecystokinin. Stimulation of gallbladder contractions in vivo by substance P was not affected by atropine. Stimulation of gallbladder strips in vitro by substance P was not affected by adrenergic antagonists or tetrodotoxin. These findings suggest that substance P may be a direct stimulant of contraction of the smooth muscle of the gallbladder.
Original language | English (US) |
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Pages (from-to) | 163-166 |
Number of pages | 4 |
Journal | Surgery Gynecology and Obstetrics |
Volume | 163 |
Issue number | 2 |
State | Published - 1986 |
Externally published | Yes |
ASJC Scopus subject areas
- Surgery
- Obstetrics and Gynecology