Effect of substance P on contractions of the gallbladder

L. Mate, T. Sakamoto, G. H. Greeley, J. C. Thompson

    Research output: Contribution to journalArticle

    9 Scopus citations

    Abstract

    The effect of substance P on contractions of the gallbladder in dogs (in vivo) and rabbits (in vitro) was examined. Substance P stimulated contraction of the gallbladder, both in vivo and in vitro; however, substance P was not as effective as cholecystokinin. Stimulation of gallbladder contractions in vivo by substance P was not affected by atropine. Stimulation of gallbladder strips in vitro by substance P was not affected by adrenergic antagonists or tetrodotoxin. These findings suggest that substance P may be a direct stimulant of contraction of the smooth muscle of the gallbladder.

    Original languageEnglish (US)
    Pages (from-to)163-166
    Number of pages4
    JournalSurgery Gynecology and Obstetrics
    Volume163
    Issue number2
    StatePublished - Jan 1 1986

      Fingerprint

    ASJC Scopus subject areas

    • Surgery
    • Obstetrics and Gynecology

    Cite this

    Mate, L., Sakamoto, T., Greeley, G. H., & Thompson, J. C. (1986). Effect of substance P on contractions of the gallbladder. Surgery Gynecology and Obstetrics, 163(2), 163-166.