Effect of substance P on contractions of the gallbladder

L. Mate, T. Sakamoto, G. H. Greeley, J. C. Thompson

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The effect of substance P on contractions of the gallbladder in dogs (in vivo) and rabbits (in vitro) was examined. Substance P stimulated contraction of the gallbladder, both in vivo and in vitro; however, substance P was not as effective as cholecystokinin. Stimulation of gallbladder contractions in vivo by substance P was not affected by atropine. Stimulation of gallbladder strips in vitro by substance P was not affected by adrenergic antagonists or tetrodotoxin. These findings suggest that substance P may be a direct stimulant of contraction of the smooth muscle of the gallbladder.

Original languageEnglish (US)
Pages (from-to)163-166
Number of pages4
JournalSurgery Gynecology and Obstetrics
Volume163
Issue number2
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Obstetrics and Gynecology

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