TY - JOUR
T1 - Effect of the Interferon Inducer, Dextran Phosphate, on Influenza Virus Infection in Mice
AU - Suzuki, Fujio
AU - Ishida, Nakao
AU - Suzuki, Masuko
AU - Sato, Takeshi
AU - Suzuki, Shigeo
N1 - Funding Information:
This work was supported by a research grant from the Ministries of Education and Welfare. The authors acknowledge the kind revision of the manuscript by Dr. Samuel Baron, Laboratory of Viral Diseases, N1AID, Bethesda.
PY - 1975/9/8
Y1 - 1975/9/8
N2 - Intraperitoneal administration of dextran phosphate (MW 40,000) or DP 40, an interferon inducer, was shown to increase the survival rate of mice infected with 10 LD50 dose of influenza A2 virus (H2N2). In the treated mice, a 1-day delay was evident in the virus growth in lung, and production of HAI antibody, when compared to the nontreated or dextran-treated controls. More significant was the 2-day delay in the development of lung consolidation, which leads to 40% survival of the treated mice. Mediation of the protection by the interferon induced by DP 40 was indicated.
AB - Intraperitoneal administration of dextran phosphate (MW 40,000) or DP 40, an interferon inducer, was shown to increase the survival rate of mice infected with 10 LD50 dose of influenza A2 virus (H2N2). In the treated mice, a 1-day delay was evident in the virus growth in lung, and production of HAI antibody, when compared to the nontreated or dextran-treated controls. More significant was the 2-day delay in the development of lung consolidation, which leads to 40% survival of the treated mice. Mediation of the protection by the interferon induced by DP 40 was indicated.
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U2 - 10.3181/00379727-149-38960
DO - 10.3181/00379727-149-38960
M3 - Article
C2 - 1166077
AN - SCOPUS:0016836509
SN - 0037-9727
VL - 149
SP - 1069
EP - 1075
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
IS - 4
ER -