Effect of the Interferon Inducer, Dextran Phosphate, on Influenza Virus Infection in Mice

Fujio Suzuki, Nakao Ishida, Masuko Suzuki, Takeshi Sato, Shigeo Suzuki

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Intraperitoneal administration of dextran phosphate (MW 40,000) or DP 40, an interferon inducer, was shown to increase the survival rate of mice infected with 10 LD50 dose of influenza A2 virus (H2N2). In the treated mice, a 1-day delay was evident in the virus growth in lung, and production of HAI antibody, when compared to the nontreated or dextran-treated controls. More significant was the 2-day delay in the development of lung consolidation, which leads to 40% survival of the treated mice. Mediation of the protection by the interferon induced by DP 40 was indicated.

Original languageEnglish (US)
Pages (from-to)1069-1075
Number of pages7
JournalProceedings of the Society for Experimental Biology and Medicine
Volume149
Issue number4
DOIs
StatePublished - Sep 8 1975
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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