Effect of the Interferon Inducer, Dextran Phosphate, on Influenza Virus Infection in Mice

Fujio Suzuki; Nakao Ishida; Masuko Suzuki; Takeshi Sato; Shigeo Suzuki

doi:10.3181/00379727-149-38960

Effect of the Interferon Inducer, Dextran Phosphate, on Influenza Virus Infection in Mice

Fujio Suzuki
, Nakao Ishida
, Masuko Suzuki
, Takeshi Sato
, Shigeo Suzuki

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Intraperitoneal administration of dextran phosphate (MW 40,000) or DP 40, an interferon inducer, was shown to increase the survival rate of mice infected with 10 LD₅₀ dose of influenza A₂ virus (H₂N₂). In the treated mice, a 1-day delay was evident in the virus growth in lung, and production of HAI antibody, when compared to the nontreated or dextran-treated controls. More significant was the 2-day delay in the development of lung consolidation, which leads to 40% survival of the treated mice. Mediation of the protection by the interferon induced by DP 40 was indicated.

Original language	English (US)
Pages (from-to)	1069-1075
Number of pages	7
Journal	Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
Volume	149
Issue number	4
DOIs	https://doi.org/10.3181/00379727-149-38960
State	Published - Sep 8 1975
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.3181/00379727-149-38960

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Effect of the Interferon Inducer, Dextran Phosphate, on Influenza Virus Infection in Mice. / Suzuki, Fujio; Ishida, Nakao; Suzuki, Masuko et al.
In: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.), Vol. 149, No. 4, 08.09.1975, p. 1069-1075.

Research output: Contribution to journal › Article › peer-review

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title = "Effect of the Interferon Inducer, Dextran Phosphate, on Influenza Virus Infection in Mice",

abstract = "Intraperitoneal administration of dextran phosphate (MW 40,000) or DP 40, an interferon inducer, was shown to increase the survival rate of mice infected with 10 LD50 dose of influenza A2 virus (H2N2). In the treated mice, a 1-day delay was evident in the virus growth in lung, and production of HAI antibody, when compared to the nontreated or dextran-treated controls. More significant was the 2-day delay in the development of lung consolidation, which leads to 40\% survival of the treated mice. Mediation of the protection by the interferon induced by DP 40 was indicated.",

author = "Fujio Suzuki and Nakao Ishida and Masuko Suzuki and Takeshi Sato and Shigeo Suzuki",

note = "Funding Information: This work was supported by a research grant from the Ministries of Education and Welfare. The authors acknowledge the kind revision of the manuscript by Dr. Samuel Baron, Laboratory of Viral Diseases, N1AID, Bethesda.",

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AU - Suzuki, Fujio

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AU - Suzuki, Masuko

AU - Sato, Takeshi

AU - Suzuki, Shigeo

N1 - Funding Information: This work was supported by a research grant from the Ministries of Education and Welfare. The authors acknowledge the kind revision of the manuscript by Dr. Samuel Baron, Laboratory of Viral Diseases, N1AID, Bethesda.

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N2 - Intraperitoneal administration of dextran phosphate (MW 40,000) or DP 40, an interferon inducer, was shown to increase the survival rate of mice infected with 10 LD50 dose of influenza A2 virus (H2N2). In the treated mice, a 1-day delay was evident in the virus growth in lung, and production of HAI antibody, when compared to the nontreated or dextran-treated controls. More significant was the 2-day delay in the development of lung consolidation, which leads to 40% survival of the treated mice. Mediation of the protection by the interferon induced by DP 40 was indicated.

AB - Intraperitoneal administration of dextran phosphate (MW 40,000) or DP 40, an interferon inducer, was shown to increase the survival rate of mice infected with 10 LD50 dose of influenza A2 virus (H2N2). In the treated mice, a 1-day delay was evident in the virus growth in lung, and production of HAI antibody, when compared to the nontreated or dextran-treated controls. More significant was the 2-day delay in the development of lung consolidation, which leads to 40% survival of the treated mice. Mediation of the protection by the interferon induced by DP 40 was indicated.

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Effect of the Interferon Inducer, Dextran Phosphate, on Influenza Virus Infection in Mice

Abstract

ASJC Scopus subject areas

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