Effect of topical applications of silver sulfadiazine on the natural killer cell activity in a rat model of thermal injury

Harbans Singh, N. Berg, David Herndon

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The effect of topical application of silver sulfadiazine cream on the natural killer (NK) cell cytotoxicity was studied in a rat model of thermal injury. The rats were given a 30% total body surface area scald injury and the NK cell cytotoxicity was studied in rats at different days postinjuiry with or without treatment with silver sulfadiazine. The NK cell activity was observed to be significantly (P < .0025) suppressed at day 7 postinjury in nontreated burned rats compared with control sham burned animals. Interestingly, in rats treated with silver sulfadiazine twice daily, no suppression in NK cell activity was observed. The application of base cream (without silver sulfadiazine) did not have nay significant effect on the NK cell activity in burned rats. The data show that the effect of silver sulfadiazine on NK cell activity may be due to the sulfadiazine component, since the serum levels of sulfadiazine (33.7 ± 1.9 μg/dL) were observed to be maximal at day 7 postinjury.

Original languageEnglish (US)
Pages (from-to)152-155
Number of pages4
JournalJournal of Burn Care and Rehabilitation
Volume9
Issue number2
StatePublished - 1988

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Silver Sulfadiazine
Natural Killer Cells
Hot Temperature
Wounds and Injuries
Sulfadiazine
Body Surface Area
Serum

ASJC Scopus subject areas

  • Emergency Medicine
  • Rehabilitation
  • Surgery
  • Nursing(all)
  • Health Professions(all)

Cite this

Effect of topical applications of silver sulfadiazine on the natural killer cell activity in a rat model of thermal injury. / Singh, Harbans; Berg, N.; Herndon, David.

In: Journal of Burn Care and Rehabilitation, Vol. 9, No. 2, 1988, p. 152-155.

Research output: Contribution to journalArticle

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