Effect of total jejunoileal denervation on fat-stimulated release of peptide YY and cholecystokinin

B. M. Evers, C. M. Townsend, T. Uchida, George H Greeley, E. Allen, J. C. Thompson

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

We have investigated the effect of total denervation of the jejunoileum (JDNv) on stimulated release of peptide YY (PYY) and cholecystokinin-33/39 in five dogs prepared with chronic gastric and duodenal cannulas. JDNv was performed by stripping the adventitia from the superior mesenteric artery and vein, transecting the small bowel mesentery, and division (with reanastomosis) of the small bowel at the ligament of Treitz and ileocecal junction. Intraduodenal corn oil (3 mg/kg/hr) was given before JDNv and 1 and 2 months after JDNv. Intravenous bombesin (400 pmol/kg/hr) was given (on nonconsecutive days) before JDNv and 1 month after JDNv. Plasma PYY and cholecystokinin levels were measured by specific radioimmunoassay. Release of PYY was enhanced after JDNv. The integrated release of PYY (ng·[0 to 60 min]/ml) after intraduodenal corn oil was as follows: before JDNv, 4.1 ± 1.2; 1 month after JDNv, 16.0 ± 2.7; and 2 months after JDNv, 10.3 ± 2.2. Similar results were noted with intravenous bombesin (3.7 ± 0.9 [before JDNv] vs 12.0 ± 0.7 [1 month after JDNv]. Corn oil-stimulated release of cholecystokinin was abolished after JDNv (before JDNv 2.2 ± 1.1; 1 month after JDNv, 0.6 ± 0.3; and 2 months after JDNv, 0.4 ± 0.6). Basal plasma levels of PYY and cholecystokinin were not affected by JDNv. We conclude that JDNv enhances PYY and abolishes cholecystokinin release, which provides evidence for different mechanisms of neural control.

Original languageEnglish (US)
Pages (from-to)248-253
Number of pages6
JournalSurgery
Volume108
Issue number2
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Surgery

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    Evers, B. M., Townsend, C. M., Uchida, T., Greeley, G. H., Allen, E., & Thompson, J. C. (1990). Effect of total jejunoileal denervation on fat-stimulated release of peptide YY and cholecystokinin. Surgery, 108(2), 248-253.