TY - JOUR
T1 - Effect of various dietary regimens on oral challenge with Mycobacterium avium subsp. paratuberculosis in a rabbit model
AU - Arrazuria, Rakel
AU - Molina, Elena
AU - Mateo-Abad, Maider
AU - Arostegui, Inmaculada
AU - Garrido, Joseba M.
AU - Juste, Ramón A.
AU - Elguezabal, Natalia
N1 - Funding Information:
This study was supported with funds from the Ministerio de Economía y Competitividad from the Spanish Government (AGL 2012-39818-C02-02 ), from the Departamento de Medio Ambiente, Planificación Territorial, Agricultura y Pesca of the Basque Government and from the Departamento de Educación, Política Científica y Cultura of the Basque Government ( IT620-13 ). RA acknowledges support from the Departamento de Educación y Universidades of the Basque Government ( BFI-2012-237 ).
Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Rabbits are susceptible to infection by Mycobacterium avium subspecies paratuberculosis (MAP) in both wildlife and experimental conditions. Under the hypotheses that nutrient balance might influence the establishment of infection, we designed an experiment where MAP intestinal colonization was assessed under three dietary regimens: high fiber, high protein, and regular diet in New Zealand white rabbits submitted to oral challenge with MAP.Lowest weight gain (F=5.17, p=0.024), higher tissue culture positivity rates (X2=7.43, p=0.024) and especially extended MAP-compatible lesions (F=5.78, p=0.017) were detected in the regular diet.Taken altogether, results indicate that paratuberculosis infection was achieved affecting mostly regular diet animals and showing that dietary changes may modulate the course of the infection.
AB - Rabbits are susceptible to infection by Mycobacterium avium subspecies paratuberculosis (MAP) in both wildlife and experimental conditions. Under the hypotheses that nutrient balance might influence the establishment of infection, we designed an experiment where MAP intestinal colonization was assessed under three dietary regimens: high fiber, high protein, and regular diet in New Zealand white rabbits submitted to oral challenge with MAP.Lowest weight gain (F=5.17, p=0.024), higher tissue culture positivity rates (X2=7.43, p=0.024) and especially extended MAP-compatible lesions (F=5.78, p=0.017) were detected in the regular diet.Taken altogether, results indicate that paratuberculosis infection was achieved affecting mostly regular diet animals and showing that dietary changes may modulate the course of the infection.
KW - Animal model
KW - Diet
KW - Infection
KW - Johne's disease
KW - Mycobacterium avium sbsp. paratuberculosis
KW - Rabbit
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U2 - 10.1016/j.rvsc.2015.06.006
DO - 10.1016/j.rvsc.2015.06.006
M3 - Article
C2 - 26267094
AN - SCOPUS:84938702719
SN - 0034-5288
VL - 101
SP - 80
EP - 83
JO - Research in Veterinary Science
JF - Research in Veterinary Science
ER -