Effect of verapamil on pulmonary reflexes in the vascularly isolated canine lung: Physiology

J. O. Nilsestuen, Robert L. Coon, M. P. Woods, J. P. Kampine

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    Abstract

    Breathing frequency (BF) may be affected by changes in the percent inspired CO2 administered to vascularly isolated lungs. Pulmonary CO2 probably affects BF, in part, through a secondary effect of CO2 on airway smooth muscle. To further determine the role of pulmonary mechanics in the pulmonary CO2-mediated BF response, Verapamil, a Ca++ blocking agent which blocks hypocapnic airway constriction, was administered to the vas­cularly isolated lungs of the dog. Verapamil blocked the hypocapnic airway constriction which occurred when pulmonary CO2 was reduced; however, the decrease in BF was not only blocked but in some animals there was an increase in BF. Also, the decrease in BF produced by hyperinflation of the lungs (Hering-Breuer reflex) was either blocked or an increase in BF occurred after administration of Verapamil.

    Original languageEnglish (US)
    Pages (from-to)110-115
    Number of pages6
    JournalRespiration
    Volume42
    Issue number2
    DOIs
    StatePublished - Jan 1 1981

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    Keywords

    • Airway resistance
    • Calcium
    • Carbon dioxide
    • Diaphragm
    • Hering-Breuer reflex
    • Lung compliance
    • Mechanoreceptors
    • Muscle smooth
    • Pulmonary circulation

    ASJC Scopus subject areas

    • Pulmonary and Respiratory Medicine

    Cite this

    Nilsestuen, J. O., Coon, R. L., Woods, M. P., & Kampine, J. P. (1981). Effect of verapamil on pulmonary reflexes in the vascularly isolated canine lung: Physiology. Respiration, 42(2), 110-115. https://doi.org/10.1159/000194419