Effect of verapamil on pulmonary reflexes in the vascularly isolated canine lung: Physiology

J. O. Nilsestuen, R. L. Coon, M. P. Woods, J. P. Kampine

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    Breathing frequency (BF) may be affected by changes in the percent inspired CO2 administered to vascularly isolated lungs. Pulmonary CO2 probably affects BF, in part, through a secondary effect of CO2 on airway smooth muscle. To further determine the role of pulmonary mechanics in the pulmonary CO2-mediated BF response. Verapamil, a Ca++ blocking agent which blocks hypocapnic airway constriction, was administered to the vascularly isolated lungs of the dog. Verapamil blocked the hypocapnic airway constriction which occurred when pulmonary CO2 was reduced; however, the decrease in BF was not only blocked but in some animals there was an increase in BF. Also, the decrease in BF produced by hyperinflation of the lungs (Hering-Breuer reflex) was either blocked or an increase in BF occurred after administration of Verapamil.

    Original languageEnglish (US)
    Pages (from-to)110-115
    Number of pages6
    JournalRespiration
    Volume42
    Issue number2
    StatePublished - 1981

    Fingerprint

    Verapamil
    Reflex
    Canidae
    Respiration
    Lung
    Constriction
    Mechanics
    Smooth Muscle
    Dogs

    ASJC Scopus subject areas

    • Physiology
    • Pulmonary and Respiratory Medicine

    Cite this

    Nilsestuen, J. O., Coon, R. L., Woods, M. P., & Kampine, J. P. (1981). Effect of verapamil on pulmonary reflexes in the vascularly isolated canine lung: Physiology. Respiration, 42(2), 110-115.

    Effect of verapamil on pulmonary reflexes in the vascularly isolated canine lung : Physiology. / Nilsestuen, J. O.; Coon, R. L.; Woods, M. P.; Kampine, J. P.

    In: Respiration, Vol. 42, No. 2, 1981, p. 110-115.

    Research output: Contribution to journalArticle

    Nilsestuen, JO, Coon, RL, Woods, MP & Kampine, JP 1981, 'Effect of verapamil on pulmonary reflexes in the vascularly isolated canine lung: Physiology', Respiration, vol. 42, no. 2, pp. 110-115.
    Nilsestuen JO, Coon RL, Woods MP, Kampine JP. Effect of verapamil on pulmonary reflexes in the vascularly isolated canine lung: Physiology. Respiration. 1981;42(2):110-115.
    Nilsestuen, J. O. ; Coon, R. L. ; Woods, M. P. ; Kampine, J. P. / Effect of verapamil on pulmonary reflexes in the vascularly isolated canine lung : Physiology. In: Respiration. 1981 ; Vol. 42, No. 2. pp. 110-115.
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