Effect of verapamil on pulmonary reflexes in the vascularly isolated canine lung: Physiology

J. O. Nilsestuen, Robert L. Coon, M. P. Woods, J. P. Kampine

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Breathing frequency (BF) may be affected by changes in the percent inspired CO2 administered to vascularly isolated lungs. Pulmonary CO2 probably affects BF, in part, through a secondary effect of CO2 on airway smooth muscle. To further determine the role of pulmonary mechanics in the pulmonary CO2-mediated BF response, Verapamil, a Ca++ blocking agent which blocks hypocapnic airway constriction, was administered to the vas­cularly isolated lungs of the dog. Verapamil blocked the hypocapnic airway constriction which occurred when pulmonary CO2 was reduced; however, the decrease in BF was not only blocked but in some animals there was an increase in BF. Also, the decrease in BF produced by hyperinflation of the lungs (Hering-Breuer reflex) was either blocked or an increase in BF occurred after administration of Verapamil.

Original languageEnglish (US)
Pages (from-to)110-115
Number of pages6
Issue number2
StatePublished - 1981
Externally publishedYes


  • Airway resistance
  • Calcium
  • Carbon dioxide
  • Diaphragm
  • Hering-Breuer reflex
  • Lung compliance
  • Mechanoreceptors
  • Muscle smooth
  • Pulmonary circulation

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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