Effect of yohimbine on brain monoamines: An in vivo study

T. Brannan, J. Martinez-Tica, M. D. Yahr

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Following the administration of yohimbine, an α2-adrenoreceptor antagonist, the levels of norepinephrine (NE), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5HIAA) increased significantly in the lateral ventricular fluid of rats. These increases were abolished when animals were pretreated with α-methyl-para-tyrosine or reserpine. Dopamine (DA) was not detected in ventricular fluid either before or after yohimbine administration. Yohimbine administration did, however, increase intracellular DA levels in the corpus striatum. These findings indicate that yohimbine promotes NE and DA release in the brain and suggest that it also modifies the activity of the serotonin system.

Original languageEnglish (US)
Pages (from-to)81-87
Number of pages7
JournalJournal of Neural Transmission - Parkinson's Disease and Dementia Section
Volume3
Issue number2
DOIs
StatePublished - Jun 1 1991

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Keywords

  • Yohimbine
  • cerebral microdialysis
  • dopamine
  • lateral ventricle
  • norepinephrine
  • striatum

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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