Effect of zidovudine postexposure prophylaxis on the development of HIV-specific cytotoxic T-lymphocyte responses in HIV-exposed healthcare workers

Ronnie D'Amico; Ligia A. Pinto; Peter Meyer; Alan L. Landay; Alan A. Harris; Mario Clerici; Jay A. Berzofsky; Gene M. Shearer; Harold A. Kessler

doi:10.1086/501646

Effect of zidovudine postexposure prophylaxis on the development of HIV-specific cytotoxic T-lymphocyte responses in HIV-exposed healthcare workers

Ronnie D'Amico, Ligia A. Pinto, Peter Meyer, Alan L. Landay, Alan A. Harris, Mario Clerici, Jay A. Berzofsky, Gene M. Shearer, Harold A. Kessler

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

We evaluated the effects of zidovudine postexposure prophylaxis (PEP) on the development of human immunodeficiency virus (HIV) envelope-specific cytotoxic T-lymphocyte responses in 20 healthcare workers with occupational exposures to HIV. Seven healthcare workers were treated with zidovudine PEP. Only 1 of 7 treated, versus 6 of 13 not treated, developed an HIV envelope-specific cytotoxic T-lymphocyte response. These data suggest that zidovudine abrogated HIV-specific cytotoxic T-lymphocyte responses. HIV-specific cytotoxic T-lymphocyte responses may be useful as a surrogate marker of HIV replication in the evaluation of new regimens for PEP of occupational HIV exposures.

Original language	English (US)
Pages (from-to)	428-430
Number of pages	3
Journal	Infection control and hospital epidemiology
Volume	20
Issue number	6
DOIs	https://doi.org/10.1086/501646
State	Published - 1999
Externally published	Yes

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

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10.1086/501646

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D'Amico, R., Pinto, L. A., Meyer, P., Landay, A. L., Harris, A. A., Clerici, M., Berzofsky, J. A., Shearer, G. M., & Kessler, H. A. (1999). Effect of zidovudine postexposure prophylaxis on the development of HIV-specific cytotoxic T-lymphocyte responses in HIV-exposed healthcare workers. Infection control and hospital epidemiology, 20(6), 428-430. https://doi.org/10.1086/501646

D'Amico, R, Pinto, LA, Meyer, P, Landay, AL, Harris, AA, Clerici, M, Berzofsky, JA, Shearer, GM & Kessler, HA 1999, 'Effect of zidovudine postexposure prophylaxis on the development of HIV-specific cytotoxic T-lymphocyte responses in HIV-exposed healthcare workers', Infection control and hospital epidemiology, vol. 20, no. 6, pp. 428-430. https://doi.org/10.1086/501646

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Effect of zidovudine postexposure prophylaxis on the development of HIV-specific cytotoxic T-lymphocyte responses in HIV-exposed healthcare workers

Abstract

ASJC Scopus subject areas

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