Effectiveness of Bivalirudin as a replacement for Heparin during cardiopulmonary bypass in patients undergoing coronary artery bypass grafting

Andreas Koster, Bruce Spiess, Derek P. Chew, Thomas Krabatsch, Luc Tambeur, Abe Deanda, Roland Hetzer, Hermann Kuppe, Nicholas G. Smedira, A. Michael Lincoff

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94 Scopus citations

Abstract

We investigated the use of bivalirudin as an anticoagulant therapy during cardiopulmonary bypass in 20 patients who underwent coronary artery bypass grafting. Primary end points consisted of clinical outcome data, whereas secondary end points focused on blood loss, transfusions, pharmacokinetics, and monitoring. Our data provide the first evidence of clinical feasibility of anticoagulation with bivalirudin during cardiopulmonary bypass.

Original languageEnglish (US)
Pages (from-to)356-359
Number of pages4
JournalAmerican Journal of Cardiology
Volume93
Issue number3
DOIs
StatePublished - Feb 1 2004

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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