Abstract
The aim of this study was to determine the effectiveness of antibiotic-impregnated implants in the prevention of bone infection. We used a model of contaminated fracture in goats to evaluate four treatment groups: no treatment, hand-made tobramycin-impregnated polymethylmethacrylate beads, commercially-available tobramycin-impregnated calcium sulphate pellets and commercially-available tobramycin-impregnated polymethylmethacrylate beads. Three weeks after intraosseous inoculation with streptomycin-resistant Staphylococcus aureurs tissue cultures showed no evidence of infection in any of the antibiotic-treated groups. All of the cultures were positive in the untreated group. These results show that effective local antibiotic delivery can be obtained with both commercially-available products and with hand-made polymethylmethacrylate, beads. The calcium sulphate pellets have the advantage of being bioabsorbable, thereby obviating the need for a second procedure to remove them.
Original language | English (US) |
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Pages (from-to) | 1102-1104 |
Number of pages | 3 |
Journal | Journal of Bone and Joint Surgery - Series B |
Volume | 88 |
Issue number | 8 |
DOIs | |
State | Published - Aug 2006 |
Externally published | Yes |
ASJC Scopus subject areas
- Surgery
- Orthopedics and Sports Medicine