Effectiveness of exercise interventions in animal models of multiple sclerosis

Abdolhossein Parnow, Muthanna Hafedh, Ikuo Tsunoda, Darpan I. Patel, Julien S. Baker, Ayoub Saeidi, Sovan Bagchi, Pallav Sengupta, Sulagna Dutta, Edyta Łuszczki, Artur Stolarczyk, Łukasz Oleksy, Maisa Hamed Al Kiyumi, Ismail Laher, Hassane Zouhal

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Multiple sclerosis (MS) is associated with an impaired immune system that severely affects the spinal cord and brain, and which is marked by progressive inflammatory demyelination. Patients with MS may benefit from exercise training as a suggested course of treatment. The most commonly used animal models of studies on MS are experimental autoimmune/allergic encephalomyelitis (EAE) models. The present review intends to concisely discuss the interventions using EAE models to understand the effectiveness of exercise as treatment for MS patients and thereby provide clear perspective for future research and MS management. For the present literature review, relevant published articles on EAE animal models that reported the impacts of exercise on MS, were extracted from various databases. Existing literature support the concept that an exercise regimen can reduce the severity of some of the clinical manifestations of EAE, including neurological signs, motor function, pain, and cognitive deficits. Further results demonstrate the mechanisms of EAE suppression with information relating to the immune system, demyelination, regeneration, and exercise in EAE. The role for neurotrophic factors has also been investigated. Analyzing the existing reports, this literature review infers that EAE is a suitable animal model that can help researchers develop further understanding and treatments for MS. Besides, findings from previous animal studies supports the contention that exercise assists in ameliorating MS progression.

Original languageEnglish (US)
Article number1143766
JournalFrontiers in Medicine
StatePublished - 2023
Externally publishedYes


  • EAE model
  • exercise training
  • motor function
  • multiple sclerosis
  • neurotrophin

ASJC Scopus subject areas

  • General Medicine


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