Abstract
Toll-like receptor (TLR) signaling has been implicated in the genesis of HIV driven chronic immune activation and inflammation. In other inflammatory diseases, TLR driven B cell regulatory functions have been described, yet in HIV pathogenesis the focus has been on an antibody-dependent role for B cells. In this review, we discuss possible effector and regulatory functions exerted by (TLR) activated B cells during HIV infection.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 348-352 |
| Number of pages | 5 |
| Journal | Autoimmunity |
| Volume | 45 |
| Issue number | 5 |
| DOIs | |
| State | Published - Aug 2012 |
| Externally published | Yes |
Keywords
- Chemokines
- Chronic Immune Activation
- IL-10
- Immune Exhaustion
- Microbial Translocation
- Proinflammatory Cytokines
- Regulatory B cells
- Toll-like Receptor
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology