Effects of 5-azacytidine on transfer RNA modification: Comparative study on normal and malignant tissues

Lee Jane Wang Lu; Grace H. Chiang; Kurt Randerath

doi:10.1016/0024-3205(80)90307-0

Effects of 5-azacytidine on transfer RNA modification: Comparative study on normal and malignant tissues

Lee Jane Wang Lu, Grace H. Chiang, Kurt Randerath

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Abstract

In general, the treatment of animals with 5-azacytidine (1-β-D-ribofuranosly-4-amino-s-triazine-2(1H)-one) was found to lead to a specific reduction of the 5-methylcytidine (m⁵C) content of tRNA in tissues, e.g. liver, hepatoma, mammary tumor, and spleen; however, the effect of the drug on post-transcriptional tRNA modification was more general in lymph nodes and in leukemic cells. Many base modifications of L1210 cell tRNA were inhibited, with m⁵C and dihydrouridine (hU) being affected the most. A positive correlation existed between the extent of inhibition of the formation of m⁵C and other modified nucleosides and the antitumor activity of the drug.

Original language	English (US)
Pages (from-to)	577-584
Number of pages	8
Journal	Life Sciences
Volume	27
Issue number	7
DOIs	https://doi.org/10.1016/0024-3205(80)90307-0
State	Published - 1980
Externally published	Yes

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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10.1016/0024-3205(80)90307-0

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title = "Effects of 5-azacytidine on transfer RNA modification: Comparative study on normal and malignant tissues",

abstract = "In general, the treatment of animals with 5-azacytidine (1-β-D-ribofuranosly-4-amino-s-triazine-2(1H)-one) was found to lead to a specific reduction of the 5-methylcytidine (m5C) content of tRNA in tissues, e.g. liver, hepatoma, mammary tumor, and spleen; however, the effect of the drug on post-transcriptional tRNA modification was more general in lymph nodes and in leukemic cells. Many base modifications of L1210 cell tRNA were inhibited, with m5C and dihydrouridine (hU) being affected the most. A positive correlation existed between the extent of inhibition of the formation of m5C and other modified nucleosides and the antitumor activity of the drug.",

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journal = "Life Sciences",

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T1 - Effects of 5-azacytidine on transfer RNA modification

T2 - Comparative study on normal and malignant tissues

AU - Lu, Lee Jane Wang

AU - Chiang, Grace H.

AU - Randerath, Kurt

PY - 1980

Y1 - 1980

N2 - In general, the treatment of animals with 5-azacytidine (1-β-D-ribofuranosly-4-amino-s-triazine-2(1H)-one) was found to lead to a specific reduction of the 5-methylcytidine (m5C) content of tRNA in tissues, e.g. liver, hepatoma, mammary tumor, and spleen; however, the effect of the drug on post-transcriptional tRNA modification was more general in lymph nodes and in leukemic cells. Many base modifications of L1210 cell tRNA were inhibited, with m5C and dihydrouridine (hU) being affected the most. A positive correlation existed between the extent of inhibition of the formation of m5C and other modified nucleosides and the antitumor activity of the drug.

AB - In general, the treatment of animals with 5-azacytidine (1-β-D-ribofuranosly-4-amino-s-triazine-2(1H)-one) was found to lead to a specific reduction of the 5-methylcytidine (m5C) content of tRNA in tissues, e.g. liver, hepatoma, mammary tumor, and spleen; however, the effect of the drug on post-transcriptional tRNA modification was more general in lymph nodes and in leukemic cells. Many base modifications of L1210 cell tRNA were inhibited, with m5C and dihydrouridine (hU) being affected the most. A positive correlation existed between the extent of inhibition of the formation of m5C and other modified nucleosides and the antitumor activity of the drug.

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Effects of 5-azacytidine on transfer RNA modification: Comparative study on normal and malignant tissues

Abstract

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