Effects of 5-fluorouridine on modified nucleosides in mouse liver transfer RNA

Leejane Lu, G. H. Chiang, W. C. Tseng, K. Randerath

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Administration of the pyrimidine antimetabolite, 5-fluorouridine, to mice was found to cause a marked specific reduction of the amounts of 5-methyluridine, pseudouridine, and dihydrouridine but not of 3-(3-amino-3-carboxypropyl)uridine in tRNA from the livers of the treated animals. The data presented indicate that this effect is not simply due to the incorporation of 5-fluorouridine into tRNA; the drug appears to interfere directly with the enzymic reactions involved in the modification of the 5-position of uridine. 5-Fluorouridine was found to have no effect on the modification of adenosine, guanosine, and cytidine in mouse liver tRNA.

Original languageEnglish (US)
Pages (from-to)1075-1082
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume73
Issue number4
DOIs
StatePublished - Dec 20 1976
Externally publishedYes

Fingerprint

Transfer RNA
Nucleosides
Liver
Pseudouridine
Antimetabolites
Cytidine
Guanosine
Uridine
Adenosine
Animals
Pharmaceutical Preparations
5-fluorouridine

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Effects of 5-fluorouridine on modified nucleosides in mouse liver transfer RNA. / Lu, Leejane; Chiang, G. H.; Tseng, W. C.; Randerath, K.

In: Biochemical and Biophysical Research Communications, Vol. 73, No. 4, 20.12.1976, p. 1075-1082.

Research output: Contribution to journalArticle

Lu, Leejane ; Chiang, G. H. ; Tseng, W. C. ; Randerath, K. / Effects of 5-fluorouridine on modified nucleosides in mouse liver transfer RNA. In: Biochemical and Biophysical Research Communications. 1976 ; Vol. 73, No. 4. pp. 1075-1082.
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