Effects of 5-fluorouridine on modified nucleosides in mouse liver transfer RNA

L. W. Lu, G. H. Chiang, W. C. Tseng, K. Randerath

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Administration of the pyrimidine antimetabolite, 5-fluorouridine, to mice was found to cause a marked specific reduction of the amounts of 5-methyluridine, pseudouridine, and dihydrouridine but not of 3-(3-amino-3-carboxypropyl)uridine in tRNA from the livers of the treated animals. The data presented indicate that this effect is not simply due to the incorporation of 5-fluorouridine into tRNA; the drug appears to interfere directly with the enzymic reactions involved in the modification of the 5-position of uridine. 5-Fluorouridine was found to have no effect on the modification of adenosine, guanosine, and cytidine in mouse liver tRNA.

Original languageEnglish (US)
Pages (from-to)1075-1082
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume73
Issue number4
DOIs
StatePublished - Dec 20 1976
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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