Effects of 5-fluorouridine on modified nucleosides in mouse liver transfer RNA

L. W. Lu; G. H. Chiang; W. C. Tseng; K. Randerath

doi:10.1016/0006-291X(76)90233-3

Effects of 5-fluorouridine on modified nucleosides in mouse liver transfer RNA

L. W. Lu, G. H. Chiang, W. C. Tseng, K. Randerath

Research output: Contribution to journal › Article › peer-review

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Abstract

Administration of the pyrimidine antimetabolite, 5-fluorouridine, to mice was found to cause a marked specific reduction of the amounts of 5-methyluridine, pseudouridine, and dihydrouridine but not of 3-(3-amino-3-carboxypropyl)uridine in tRNA from the livers of the treated animals. The data presented indicate that this effect is not simply due to the incorporation of 5-fluorouridine into tRNA; the drug appears to interfere directly with the enzymic reactions involved in the modification of the 5-position of uridine. 5-Fluorouridine was found to have no effect on the modification of adenosine, guanosine, and cytidine in mouse liver tRNA.

Original language	English (US)
Pages (from-to)	1075-1082
Number of pages	8
Journal	Biochemical and Biophysical Research Communications
Volume	73
Issue number	4
DOIs	https://doi.org/10.1016/0006-291X(76)90233-3
State	Published - Dec 20 1976
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/0006-291X(76)90233-3

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title = "Effects of 5-fluorouridine on modified nucleosides in mouse liver transfer RNA",

abstract = "Administration of the pyrimidine antimetabolite, 5-fluorouridine, to mice was found to cause a marked specific reduction of the amounts of 5-methyluridine, pseudouridine, and dihydrouridine but not of 3-(3-amino-3-carboxypropyl)uridine in tRNA from the livers of the treated animals. The data presented indicate that this effect is not simply due to the incorporation of 5-fluorouridine into tRNA; the drug appears to interfere directly with the enzymic reactions involved in the modification of the 5-position of uridine. 5-Fluorouridine was found to have no effect on the modification of adenosine, guanosine, and cytidine in mouse liver tRNA.",

author = "Lu, {L. W.} and Chiang, {G. H.} and Tseng, {W. C.} and K. Randerath",

note = "Funding Information: PRA-108. CA-13591 ACKNOWLEDGEMENTS. (05) We thank and American Dr. Erika This Cancer Randerath study Society was supported for Faculty discussions by Research USPHS and Grant comments Award Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

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doi = "10.1016/0006-291X(76)90233-3",

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T1 - Effects of 5-fluorouridine on modified nucleosides in mouse liver transfer RNA

AU - Lu, L. W.

AU - Chiang, G. H.

AU - Tseng, W. C.

AU - Randerath, K.

N1 - Funding Information: PRA-108. CA-13591 ACKNOWLEDGEMENTS. (05) We thank and American Dr. Erika This Cancer Randerath study Society was supported for Faculty discussions by Research USPHS and Grant comments Award Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 1976/12/20

Y1 - 1976/12/20

N2 - Administration of the pyrimidine antimetabolite, 5-fluorouridine, to mice was found to cause a marked specific reduction of the amounts of 5-methyluridine, pseudouridine, and dihydrouridine but not of 3-(3-amino-3-carboxypropyl)uridine in tRNA from the livers of the treated animals. The data presented indicate that this effect is not simply due to the incorporation of 5-fluorouridine into tRNA; the drug appears to interfere directly with the enzymic reactions involved in the modification of the 5-position of uridine. 5-Fluorouridine was found to have no effect on the modification of adenosine, guanosine, and cytidine in mouse liver tRNA.

AB - Administration of the pyrimidine antimetabolite, 5-fluorouridine, to mice was found to cause a marked specific reduction of the amounts of 5-methyluridine, pseudouridine, and dihydrouridine but not of 3-(3-amino-3-carboxypropyl)uridine in tRNA from the livers of the treated animals. The data presented indicate that this effect is not simply due to the incorporation of 5-fluorouridine into tRNA; the drug appears to interfere directly with the enzymic reactions involved in the modification of the 5-position of uridine. 5-Fluorouridine was found to have no effect on the modification of adenosine, guanosine, and cytidine in mouse liver tRNA.

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Effects of 5-fluorouridine on modified nucleosides in mouse liver transfer RNA

Abstract

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