Effects of a simple prototype respiratory muscle trainer on respiratory muscle strength, quality of life and dyspnea, and oxidative stress in COPD patients: A preliminary study

Jirakrit Leelarungrayub, Decha Pinkaew, Rungthip Puntumetakul, Jakkrit Klaphajone

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: The aim of this study was to evaluate the efficiency of a simple prototype device for training respiratory muscles in lung function, respiratory muscle strength, walking capacity, quality of life (QOL), dyspnea, and oxidative stress in patients with COPD. Methods: Thirty COPD patients with moderate severity of the disease were randomized into three groups: control (n=10, 6 males and 4 females), standard training (n=10, 4 males and 6 females), and prototype device (n=10, 5 males and 5 females). Respiratory muscle strength (maximal inspiratory pressure [PImax] and maximal expiratory pressure [PEmax]), lung function (forced vital capacity [FVC], percentage of FVC, forced expiratory volume in 1 second [FEV1], percentage of FEV1 [FEV1%], and FEV1/FVC), 6-minute walking distance (6MWD), QOL, and oxidative stress markers (total antioxidant capacity [TAC]), glutathione (GSH), malondialdehyde (MDA), and nitric oxide (NO) were evaluated before and after 6 weeks of training. Moreover, dyspnea scores were assessed before; during week 2, 4, and 6 of training; and at rest after training. Results: All parameters between the groups had no statistical difference before training, and no statistical change in the control group after week 6. FVC, FEV1/FVC, PImax, PEmax, QOL, MDA, and NO showed significant changes after 6 weeks of training with either the standard or prototype device, compared to pre-training. FEV1, FEV1%, 6MWD, TAC, and GSH data did not change statistically. Furthermore, the results of significant changes in all parameters were not statistically different between training groups using the standard and prototype device. The peak dyspnea scores increased significantly in week 4 and 6 when applying the standard or prototype device, and then lowered significantly at rest after 6 weeks of training, compared to pre-training. Conclusion: This study proposes that a simple prototype device can be used clinically in COPD patients as a standard device to train respiratory muscles, improving lung function and QOL, as well as involving MDA and NO levels.

Original languageEnglish (US)
Pages (from-to)1415-1425
Number of pages11
JournalInternational Journal of COPD
Volume12
DOIs
StatePublished - May 12 2017
Externally publishedYes

Fingerprint

Respiratory Muscles
Forced Expiratory Volume
Muscle Strength
Psychological Stress
Dyspnea
Chronic Obstructive Pulmonary Disease
Oxidative Stress
Vital Capacity
Quality of Life
Equipment and Supplies
Malondialdehyde
Walking
Nitric Oxide
Lung
Antioxidants
Breathing Exercises
Control Groups
Glutathione

Keywords

  • COPD
  • Lung function
  • Oxidative stress
  • PImax
  • Prototype simple training device
  • Quality of life

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Health Policy
  • Public Health, Environmental and Occupational Health

Cite this

Effects of a simple prototype respiratory muscle trainer on respiratory muscle strength, quality of life and dyspnea, and oxidative stress in COPD patients : A preliminary study. / Leelarungrayub, Jirakrit; Pinkaew, Decha; Puntumetakul, Rungthip; Klaphajone, Jakkrit.

In: International Journal of COPD, Vol. 12, 12.05.2017, p. 1415-1425.

Research output: Contribution to journalArticle

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AU - Puntumetakul, Rungthip

AU - Klaphajone, Jakkrit

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