Effects of age on behavioral signs of neuropathic pain in an experimental rat model

Jin Mo Chung; Yoon Choi; Young Wook Yoon; Heung Sik Na

doi:10.1016/0304-3940(94)11113-W

Effects of age on behavioral signs of neuropathic pain in an experimental rat model

Jin Mo Chung, Yoon Choi, Young Wook Yoon, Heung Sik Na

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

The present study examined the effect that aging has on the manifestations of pain behaviors in a rat model of neuropathic pain. Two experiments were conducted. The first experiment compared young, mature and old rats. After tight ligation of the L5 and L6 segmental spinal nerves, young rats displayed much more vigorous behavioral signs of mechanical allodynia and ongoing pain than did either mature or old rats. The second experiment was done using the same rats at two different time points. Spinal nerve ligation was done on the left side of rats when they were young and the same surgery was repeated on the right side 20 weeks later (mature age). Comparison of pain behaviors between the left and right sides confirmed the results of the first experiment. The data suggest that younger rats show much more robust behavioral signs of neuropathic pain compared to older rats.

Original language	English (US)
Pages (from-to)	54-57
Number of pages	4
Journal	Neuroscience Letters
Volume	183
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3940(94)11113-W
State	Published - Jan 2 1995

Keywords

Causalgia
Hyperalgesia
Peripheral nerve injury
Sympathetically maintained pain

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(94)11113-W

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title = "Effects of age on behavioral signs of neuropathic pain in an experimental rat model",

abstract = "The present study examined the effect that aging has on the manifestations of pain behaviors in a rat model of neuropathic pain. Two experiments were conducted. The first experiment compared young, mature and old rats. After tight ligation of the L5 and L6 segmental spinal nerves, young rats displayed much more vigorous behavioral signs of mechanical allodynia and ongoing pain than did either mature or old rats. The second experiment was done using the same rats at two different time points. Spinal nerve ligation was done on the left side of rats when they were young and the same surgery was repeated on the right side 20 weeks later (mature age). Comparison of pain behaviors between the left and right sides confirmed the results of the first experiment. The data suggest that younger rats show much more robust behavioral signs of neuropathic pain compared to older rats.",

keywords = "Causalgia, Hyperalgesia, Peripheral nerve injury, Sympathetically maintained pain",

author = "Chung, {Jin Mo} and Yoon Choi and Yoon, {Young Wook} and Na, {Heung Sik}",

note = "Funding Information: This work was supported by NIH Grants NS 31680 and NS 11255. We wish to thank Margie Watson for editorial help.",

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AU - Chung, Jin Mo

AU - Choi, Yoon

AU - Yoon, Young Wook

AU - Na, Heung Sik

N1 - Funding Information: This work was supported by NIH Grants NS 31680 and NS 11255. We wish to thank Margie Watson for editorial help.

PY - 1995/1/2

Y1 - 1995/1/2

N2 - The present study examined the effect that aging has on the manifestations of pain behaviors in a rat model of neuropathic pain. Two experiments were conducted. The first experiment compared young, mature and old rats. After tight ligation of the L5 and L6 segmental spinal nerves, young rats displayed much more vigorous behavioral signs of mechanical allodynia and ongoing pain than did either mature or old rats. The second experiment was done using the same rats at two different time points. Spinal nerve ligation was done on the left side of rats when they were young and the same surgery was repeated on the right side 20 weeks later (mature age). Comparison of pain behaviors between the left and right sides confirmed the results of the first experiment. The data suggest that younger rats show much more robust behavioral signs of neuropathic pain compared to older rats.

AB - The present study examined the effect that aging has on the manifestations of pain behaviors in a rat model of neuropathic pain. Two experiments were conducted. The first experiment compared young, mature and old rats. After tight ligation of the L5 and L6 segmental spinal nerves, young rats displayed much more vigorous behavioral signs of mechanical allodynia and ongoing pain than did either mature or old rats. The second experiment was done using the same rats at two different time points. Spinal nerve ligation was done on the left side of rats when they were young and the same surgery was repeated on the right side 20 weeks later (mature age). Comparison of pain behaviors between the left and right sides confirmed the results of the first experiment. The data suggest that younger rats show much more robust behavioral signs of neuropathic pain compared to older rats.

KW - Causalgia

KW - Hyperalgesia

KW - Peripheral nerve injury

KW - Sympathetically maintained pain

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Effects of age on behavioral signs of neuropathic pain in an experimental rat model

Abstract

Keywords

ASJC Scopus subject areas

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