Effects of aging on immune function

Edith A. Burns, James Goodwin

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

A variety of changes are observed in the immune system in both animals and humans with increasing age. There is a decline in the functional capacity of the cell populations that mount generalized and focused immune responses, and decreasing production and response of these cells to regulatory signals and proteins. These changes translate into less effective innate and adaptive immune responses, increased reactivity against self-antigens in vivo, and an increased incidence of infection. There may also be an increased risk of mortality. The mechanisms underlying age-related changes in immune function are not fully understood, but are likely to be multifactorial, including environmental and behavioral factors that affect over-all immune function from the molecular level to that of the entire organism.

Original languageEnglish (US)
Pages (from-to)9-18
Number of pages10
JournalJournal of Nutrition, Health and Aging
Volume8
Issue number1
StatePublished - 2004

Fingerprint

Autoantigens
Adaptive Immunity
Innate Immunity
immune system
Immune System
immune response
cells
antigens
incidence
Mortality
Incidence
organisms
Infection
infection
Population
animals
Proteins
proteins
innate immunity
adaptive immunity

Keywords

  • Aging
  • Apoptosis
  • Cytokines
  • Immunity
  • Lymphocytes
  • Macrophages
  • Natural killer cells

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Aging
  • Endocrinology
  • Food Science

Cite this

Effects of aging on immune function. / Burns, Edith A.; Goodwin, James.

In: Journal of Nutrition, Health and Aging, Vol. 8, No. 1, 2004, p. 9-18.

Research output: Contribution to journalArticle

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