Effects of alcohol on hemostasis.

Raneem O. Salem, Michael Laposata

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Several epidemiologic studies have shown that moderate intake of alcohol is associated with a lower risk of cardiovascular disease (CVD), but the mechanism is not fully elucidated. One of the proposed mechanisms of the protective effect of moderate alcohol intake is its beneficial effect on hemostasis. The aim of this review is to summarize the effect of ethanol intake on platelet aggregation and activation, coagulation factors including von Willebrand factor (vWF), and the fibrinolytic system. With regard to the effect of alcohol on platelet function, evidence in the literature suggests both platelet activation and platelet inhibition by ethanol. A unifying hypothesis is that platelets are partially activated by ethanol, with partial degranulation allowing for continued circulation of platelets with impaired function. Evidence also exists showing that ethanol intake decreases fibrinogen, factor VII, and vWF levels. In addition, alcohol intake has been found to increase fibrinolysis by increasing tissue plasminogen activator activity. The effect of ethanol on platelets, coagulation factors, and the fibrinolytic system is likely to contribute to protection against CVD.

Original languageEnglish (US)
JournalAmerican Journal of Clinical Pathology
Volume123 Suppl
StatePublished - Jun 2005
Externally publishedYes

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Hemostasis
Ethanol
Blood Platelets
Alcohols
Blood Coagulation Factors
Platelet Activation
von Willebrand Factor
Cardiovascular Diseases
Factor VII
Fibrinolysis
Tissue Plasminogen Activator
Platelet Aggregation
Fibrinogen
Epidemiologic Studies

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Effects of alcohol on hemostasis. / Salem, Raneem O.; Laposata, Michael.

In: American Journal of Clinical Pathology, Vol. 123 Suppl, 06.2005.

Research output: Contribution to journalArticle

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