Effects of allopurinol on smoke inhalation in the ovine model

S. Y. Ahn, K. Sugi, P. Talke, J. L. Theissen, H. A. Linares, L. D. Traber, David Herndon, D. L. Traber

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We hypothesized that the pulmonary damage induced by smoke inhalation is the result of ischemic reperfusion injury. We determined the effect of allopurinol (xanthine oxidase inhibitor) on the pulmonary microvascular fluid flux in an ovine model after inhalation of cotton smoke (n = 13) and compared these data with those from untreated similarly smoke-injured (n = 7), as well as sham- (air, n = 9) smoked, animals and sheep given an equivalent dose of CO (n = 7). Smoke injury resulted in an increased lung lymph flow, lymph-to-plasma protein ratio, lung content of polymorphonuclear cells, and extravascular lung water (gravametric), in addition to histological evidence of tissue (pulmonary) edema and destruction. No significant difference was found in these variables between the sheep that were injured with smoke whether or not they were pretreated with allopurinol. The sham-smoked and CO-insufflated animals showed no significant changes in cardiopulmonary function or morphology. We conclude that there are few data to support a role of ischemic reperfusion injury in the pulmonary damage seen after smoke inhalation.

Original languageEnglish (US)
Pages (from-to)228-234
Number of pages7
JournalJournal of Applied Physiology
Volume68
Issue number1
StatePublished - 1990

Fingerprint

Allopurinol
Smoke
Inhalation
Sheep
Lung
Lymph
Carbon Monoxide
Reperfusion Injury
Extravascular Lung Water
Xanthine Oxidase
Pulmonary Edema
Blood Proteins
Air
Wounds and Injuries

Keywords

  • lung lymph
  • pulmonary
  • sheep
  • xanthine oxidase

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Ahn, S. Y., Sugi, K., Talke, P., Theissen, J. L., Linares, H. A., Traber, L. D., ... Traber, D. L. (1990). Effects of allopurinol on smoke inhalation in the ovine model. Journal of Applied Physiology, 68(1), 228-234.

Effects of allopurinol on smoke inhalation in the ovine model. / Ahn, S. Y.; Sugi, K.; Talke, P.; Theissen, J. L.; Linares, H. A.; Traber, L. D.; Herndon, David; Traber, D. L.

In: Journal of Applied Physiology, Vol. 68, No. 1, 1990, p. 228-234.

Research output: Contribution to journalArticle

Ahn, SY, Sugi, K, Talke, P, Theissen, JL, Linares, HA, Traber, LD, Herndon, D & Traber, DL 1990, 'Effects of allopurinol on smoke inhalation in the ovine model', Journal of Applied Physiology, vol. 68, no. 1, pp. 228-234.
Ahn SY, Sugi K, Talke P, Theissen JL, Linares HA, Traber LD et al. Effects of allopurinol on smoke inhalation in the ovine model. Journal of Applied Physiology. 1990;68(1):228-234.
Ahn, S. Y. ; Sugi, K. ; Talke, P. ; Theissen, J. L. ; Linares, H. A. ; Traber, L. D. ; Herndon, David ; Traber, D. L. / Effects of allopurinol on smoke inhalation in the ovine model. In: Journal of Applied Physiology. 1990 ; Vol. 68, No. 1. pp. 228-234.
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