Effects of anesthesia, surgery, fluid resuscitation, and endotoxin administration on postburn bacterial translocation

R. Tokyay, S. T. Zeigler, J. P. Heggers, H. M. Loick, D. L. Traber, David Herndon

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The aim of the study reported here was to assess the effects of some clinically relevant factors on the incidence and outcome of postburn bacterial translocation. Miniature pigs in 8 groups (n = 6 in each) underwent: (1) general anesthesia (GA); (2) operation (insertion of Swan-Ganz, arterial, and portal catheters) under GA; (4) burn and operation; (5) burn, operation, and resuscitation (Parkland); (6) burn, operation, and resuscitation plus endotoxin (100 μg/kg IV bolus, 2nd day). Groups 1-6 were killed at 48 hours and tissue samples were harvested for bacteriologic culture. Groups 7 and 8 were the same as 2 and 5, respectively, but were killed at 96 hours. Resuscitation and endotoxin increased postburn bacterial translocation but only endotoxin promoted systemic sepsis. In the absence of additional trauma, translocated bacteria were cleared by 96 hours postburn.

Original languageEnglish (US)
Pages (from-to)1376-1379
Number of pages4
JournalJournal of Trauma
Volume31
Issue number10
StatePublished - 1991

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Bacterial Translocation
Endotoxins
Resuscitation
Anesthesia
General Anesthesia
Sepsis
Swine
Catheters
Bacteria
Incidence
Wounds and Injuries

ASJC Scopus subject areas

  • Surgery

Cite this

Tokyay, R., Zeigler, S. T., Heggers, J. P., Loick, H. M., Traber, D. L., & Herndon, D. (1991). Effects of anesthesia, surgery, fluid resuscitation, and endotoxin administration on postburn bacterial translocation. Journal of Trauma, 31(10), 1376-1379.

Effects of anesthesia, surgery, fluid resuscitation, and endotoxin administration on postburn bacterial translocation. / Tokyay, R.; Zeigler, S. T.; Heggers, J. P.; Loick, H. M.; Traber, D. L.; Herndon, David.

In: Journal of Trauma, Vol. 31, No. 10, 1991, p. 1376-1379.

Research output: Contribution to journalArticle

Tokyay, R, Zeigler, ST, Heggers, JP, Loick, HM, Traber, DL & Herndon, D 1991, 'Effects of anesthesia, surgery, fluid resuscitation, and endotoxin administration on postburn bacterial translocation', Journal of Trauma, vol. 31, no. 10, pp. 1376-1379.
Tokyay R, Zeigler ST, Heggers JP, Loick HM, Traber DL, Herndon D. Effects of anesthesia, surgery, fluid resuscitation, and endotoxin administration on postburn bacterial translocation. Journal of Trauma. 1991;31(10):1376-1379.
Tokyay, R. ; Zeigler, S. T. ; Heggers, J. P. ; Loick, H. M. ; Traber, D. L. ; Herndon, David. / Effects of anesthesia, surgery, fluid resuscitation, and endotoxin administration on postburn bacterial translocation. In: Journal of Trauma. 1991 ; Vol. 31, No. 10. pp. 1376-1379.
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