Effects of anti-thymocyte serum on 17-D yellow fever infection in adult Mice

M. S. Hirsch, F. A. Murphy

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

MANY neurotropic viral infections are accompanied by inflammatory cellular infiltrates of the central nervous system. With some of these viruses, notably lymphocytic choriomeningitis (LCM), the cellular response is believed to be responsible for the morbidity and mortality associated with infection1, and suppression of the lymphocytic response by treatment with anti-thymocyte serum prevents clinical signs of disease2,3. Yellow fever infection caused by the 17-D virus in mice is characterized by a diffuse encephalomyelitis consisting of mononuclear cell infiltration of leptomeninges and perivascular areas, as well as neuronal degeneration and glial proliferation4. We have used rabbit anti-mouse thymocyte (RAMT) serum to prevent cellular responsiveness to 11-D virus, in order to evaluate the role of delayed hypersensitivity in the pathogenesis of experimental yellow fever.

Original languageEnglish (US)
Pages (from-to)179-180
Number of pages2
JournalNature
Volume216
Issue number5111
DOIs
StatePublished - 1967

Fingerprint

Yellow Fever
Thymocytes
Viruses
Lymphocytic choriomeningitis virus
Encephalomyelitis
Delayed Hypersensitivity
Virus Diseases
Infection
Serum
Neuroglia
Central Nervous System
Rabbits
Morbidity
Mortality

ASJC Scopus subject areas

  • General

Cite this

Effects of anti-thymocyte serum on 17-D yellow fever infection in adult Mice. / Hirsch, M. S.; Murphy, F. A.

In: Nature, Vol. 216, No. 5111, 1967, p. 179-180.

Research output: Contribution to journalArticle

Hirsch, M. S. ; Murphy, F. A. / Effects of anti-thymocyte serum on 17-D yellow fever infection in adult Mice. In: Nature. 1967 ; Vol. 216, No. 5111. pp. 179-180.
@article{725c0fa43e7c429a8e9449ca7fcbb76b,
title = "Effects of anti-thymocyte serum on 17-D yellow fever infection in adult Mice",
abstract = "MANY neurotropic viral infections are accompanied by inflammatory cellular infiltrates of the central nervous system. With some of these viruses, notably lymphocytic choriomeningitis (LCM), the cellular response is believed to be responsible for the morbidity and mortality associated with infection1, and suppression of the lymphocytic response by treatment with anti-thymocyte serum prevents clinical signs of disease2,3. Yellow fever infection caused by the 17-D virus in mice is characterized by a diffuse encephalomyelitis consisting of mononuclear cell infiltration of leptomeninges and perivascular areas, as well as neuronal degeneration and glial proliferation4. We have used rabbit anti-mouse thymocyte (RAMT) serum to prevent cellular responsiveness to 11-D virus, in order to evaluate the role of delayed hypersensitivity in the pathogenesis of experimental yellow fever.",
author = "Hirsch, {M. S.} and Murphy, {F. A.}",
year = "1967",
doi = "10.1038/216179a0",
language = "English (US)",
volume = "216",
pages = "179--180",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "5111",

}

TY - JOUR

T1 - Effects of anti-thymocyte serum on 17-D yellow fever infection in adult Mice

AU - Hirsch, M. S.

AU - Murphy, F. A.

PY - 1967

Y1 - 1967

N2 - MANY neurotropic viral infections are accompanied by inflammatory cellular infiltrates of the central nervous system. With some of these viruses, notably lymphocytic choriomeningitis (LCM), the cellular response is believed to be responsible for the morbidity and mortality associated with infection1, and suppression of the lymphocytic response by treatment with anti-thymocyte serum prevents clinical signs of disease2,3. Yellow fever infection caused by the 17-D virus in mice is characterized by a diffuse encephalomyelitis consisting of mononuclear cell infiltration of leptomeninges and perivascular areas, as well as neuronal degeneration and glial proliferation4. We have used rabbit anti-mouse thymocyte (RAMT) serum to prevent cellular responsiveness to 11-D virus, in order to evaluate the role of delayed hypersensitivity in the pathogenesis of experimental yellow fever.

AB - MANY neurotropic viral infections are accompanied by inflammatory cellular infiltrates of the central nervous system. With some of these viruses, notably lymphocytic choriomeningitis (LCM), the cellular response is believed to be responsible for the morbidity and mortality associated with infection1, and suppression of the lymphocytic response by treatment with anti-thymocyte serum prevents clinical signs of disease2,3. Yellow fever infection caused by the 17-D virus in mice is characterized by a diffuse encephalomyelitis consisting of mononuclear cell infiltration of leptomeninges and perivascular areas, as well as neuronal degeneration and glial proliferation4. We have used rabbit anti-mouse thymocyte (RAMT) serum to prevent cellular responsiveness to 11-D virus, in order to evaluate the role of delayed hypersensitivity in the pathogenesis of experimental yellow fever.

UR - http://www.scopus.com/inward/record.url?scp=0014202891&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0014202891&partnerID=8YFLogxK

U2 - 10.1038/216179a0

DO - 10.1038/216179a0

M3 - Article

C2 - 6057231

AN - SCOPUS:0014202891

VL - 216

SP - 179

EP - 180

JO - Nature

JF - Nature

SN - 0028-0836

IS - 5111

ER -