Effects of anti-thymocyte serum on rauscher virus infection of mice

M. S. Hirsch, F. A. Murphy

Research output: Contribution to journalLetter

31 Scopus citations

Abstract

CELL-MEDIATED immune responses seem to be the principal host defence against virus-induced tumours and leukaemias1. Transfer of sensitized lymphoid cells can produce resistance to tumour induction or transplantation, whereas depression of cell-mediated immune mechanisms results in enhanced susceptibility to viral oncogenesis or leukaemogenesis2. The most potent suppressants of cellular immunity yet described are anti-lymphoid sera3. These sera have been used primarily to suppress homograft rejection after tissue transplantation, but have also been used to investigate mechanisms of viral pathogenesis. They have been found to potentiate polyoma and adenovirus oncogenesis4,5, as well as Moloney virus leukaemogenesis5, whereas they delay or prevent signs of lyinphocytic choriomeningitis (LCM) and yellow fever infections6-9. We report an examination of the effects of rabbit anti-mouse thymocyte (RAMT) serum on the development of Rauscher leukaemia virus infection.

Original languageEnglish (US)
Pages (from-to)478-479
Number of pages2
JournalNature
Volume218
Issue number5140
DOIs
StatePublished - Dec 1 1968

ASJC Scopus subject areas

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