Effects of antibodies to nerve growth factor on sprouting following spinal cord hemisection in the rat

C. E. Hulsebosch; J. R. Perez-Polo; R. E. Coggeshall

doi:10.1016/0304-3940(84)90214-3

Effects of antibodies to nerve growth factor on sprouting following spinal cord hemisection in the rat

C. E. Hulsebosch, J. R. Perez-Polo, R. E. Coggeshall

Neuroscience & Cell

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Dorsal root unmyelinated axons in 30-day-old rats in which the spinal cord has been hemisected at birth are more numerous on the operated side in animals that receive preimmune serum daily from hemisection to sacrifice. This is interpreted as indicating that sprouting of sensory axons occurred on the operated side. In animals with hemisected cords treated daily with antibodies to nerve growth factor (anti-NGF), the same numbers of unmyelinated axons are found in the roots on the operated side, but there are even more unmyelinated axons on the unoperated side. Our interpretation is that anti-NGF results in sensory axon sprouting with more sprouts on the unoperated side. Thus removal of NGF in cord hemisected newborn rats has an effect on sensory axon numbers.

Original language	English (US)
Pages (from-to)	19-23
Number of pages	5
Journal	Neuroscience Letters
Volume	44
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(84)90214-3
State	Published - Jan 27 1984

Keywords

axonal sprouting
nerve growth factor
rat
regeneration
unmyelinated axons

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(84)90214-3

Cite this

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title = "Effects of antibodies to nerve growth factor on sprouting following spinal cord hemisection in the rat",

abstract = "Dorsal root unmyelinated axons in 30-day-old rats in which the spinal cord has been hemisected at birth are more numerous on the operated side in animals that receive preimmune serum daily from hemisection to sacrifice. This is interpreted as indicating that sprouting of sensory axons occurred on the operated side. In animals with hemisected cords treated daily with antibodies to nerve growth factor (anti-NGF), the same numbers of unmyelinated axons are found in the roots on the operated side, but there are even more unmyelinated axons on the unoperated side. Our interpretation is that anti-NGF results in sensory axon sprouting with more sprouts on the unoperated side. Thus removal of NGF in cord hemisected newborn rats has an effect on sensory axon numbers.",

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T1 - Effects of antibodies to nerve growth factor on sprouting following spinal cord hemisection in the rat

AU - Hulsebosch, C. E.

AU - Perez-Polo, J. R.

AU - Coggeshall, R. E.

PY - 1984/1/27

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N2 - Dorsal root unmyelinated axons in 30-day-old rats in which the spinal cord has been hemisected at birth are more numerous on the operated side in animals that receive preimmune serum daily from hemisection to sacrifice. This is interpreted as indicating that sprouting of sensory axons occurred on the operated side. In animals with hemisected cords treated daily with antibodies to nerve growth factor (anti-NGF), the same numbers of unmyelinated axons are found in the roots on the operated side, but there are even more unmyelinated axons on the unoperated side. Our interpretation is that anti-NGF results in sensory axon sprouting with more sprouts on the unoperated side. Thus removal of NGF in cord hemisected newborn rats has an effect on sensory axon numbers.

AB - Dorsal root unmyelinated axons in 30-day-old rats in which the spinal cord has been hemisected at birth are more numerous on the operated side in animals that receive preimmune serum daily from hemisection to sacrifice. This is interpreted as indicating that sprouting of sensory axons occurred on the operated side. In animals with hemisected cords treated daily with antibodies to nerve growth factor (anti-NGF), the same numbers of unmyelinated axons are found in the roots on the operated side, but there are even more unmyelinated axons on the unoperated side. Our interpretation is that anti-NGF results in sensory axon sprouting with more sprouts on the unoperated side. Thus removal of NGF in cord hemisected newborn rats has an effect on sensory axon numbers.

KW - axonal sprouting

KW - nerve growth factor

KW - rat

KW - regeneration

KW - unmyelinated axons

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Effects of antibodies to nerve growth factor on sprouting following spinal cord hemisection in the rat

Abstract

Keywords

ASJC Scopus subject areas

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