Effects of apocynin and ethanol on intracerebral haemorrhage-induced brain injury in rats

Elena Titova, Robert P. Ostrowski, Lawrence Sowers, John H. Zhang, Jiping Tang

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

1. In the present study, we investigated whether the administration of apocynin, an NADPH oxidase inhibitor, provided brain protection in a rat model of intracerebral haemorrhage (ICH). 2. Rats were divided into sham, ICH untreated, ICH treated with vehicle (ethanol) and ICH treated with apocynin groups. Intracerebral haemorrhage was induced by collagenase injection. Neurological function, haemorrhage volume and brain oedema were measured 24 h after ICH. 3. Intracerebral haemorrhage caused significant neurological deficit associated with brain oedema. Apocynin (3, 10 and 30 mg/kg) failed to reduce brain injury after ICH. Low dose ethanol (0.2 g/kg) improved neurological function and reduced brain oedema (ICH-vehicle vs ICH-untreated, P < 0.05). 4. In conclusion, apocynin has no neuroprotective effect when administered intraperitoneally after ICH.

Original languageEnglish (US)
Pages (from-to)845-850
Number of pages6
JournalClinical and Experimental Pharmacology and Physiology
Volume34
Issue number9
DOIs
StatePublished - Sep 2007
Externally publishedYes

Fingerprint

Cerebral Hemorrhage
Brain Injuries
Ethanol
Brain Edema
acetovanillone
NADPH Oxidase
Neuroprotective Agents
Collagenases
Hemorrhage
Injections

Keywords

  • Apocynin
  • Collagenase
  • Ethanol
  • Intracerebral haemorrhage
  • Oedema
  • Oxidative stress

ASJC Scopus subject areas

  • Physiology
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Effects of apocynin and ethanol on intracerebral haemorrhage-induced brain injury in rats. / Titova, Elena; Ostrowski, Robert P.; Sowers, Lawrence; Zhang, John H.; Tang, Jiping.

In: Clinical and Experimental Pharmacology and Physiology, Vol. 34, No. 9, 09.2007, p. 845-850.

Research output: Contribution to journalArticle

Titova, Elena ; Ostrowski, Robert P. ; Sowers, Lawrence ; Zhang, John H. ; Tang, Jiping. / Effects of apocynin and ethanol on intracerebral haemorrhage-induced brain injury in rats. In: Clinical and Experimental Pharmacology and Physiology. 2007 ; Vol. 34, No. 9. pp. 845-850.
@article{36ec7cd73f0a4e11b4b865675c3477b6,
title = "Effects of apocynin and ethanol on intracerebral haemorrhage-induced brain injury in rats",
abstract = "1. In the present study, we investigated whether the administration of apocynin, an NADPH oxidase inhibitor, provided brain protection in a rat model of intracerebral haemorrhage (ICH). 2. Rats were divided into sham, ICH untreated, ICH treated with vehicle (ethanol) and ICH treated with apocynin groups. Intracerebral haemorrhage was induced by collagenase injection. Neurological function, haemorrhage volume and brain oedema were measured 24 h after ICH. 3. Intracerebral haemorrhage caused significant neurological deficit associated with brain oedema. Apocynin (3, 10 and 30 mg/kg) failed to reduce brain injury after ICH. Low dose ethanol (0.2 g/kg) improved neurological function and reduced brain oedema (ICH-vehicle vs ICH-untreated, P < 0.05). 4. In conclusion, apocynin has no neuroprotective effect when administered intraperitoneally after ICH.",
keywords = "Apocynin, Collagenase, Ethanol, Intracerebral haemorrhage, Oedema, Oxidative stress",
author = "Elena Titova and Ostrowski, {Robert P.} and Lawrence Sowers and Zhang, {John H.} and Jiping Tang",
year = "2007",
month = "9",
doi = "10.1111/j.1440-1681.2007.04664.x",
language = "English (US)",
volume = "34",
pages = "845--850",
journal = "Clinical and Experimental Pharmacology and Physiology",
issn = "0305-1870",
publisher = "Wiley-Blackwell",
number = "9",

}

TY - JOUR

T1 - Effects of apocynin and ethanol on intracerebral haemorrhage-induced brain injury in rats

AU - Titova, Elena

AU - Ostrowski, Robert P.

AU - Sowers, Lawrence

AU - Zhang, John H.

AU - Tang, Jiping

PY - 2007/9

Y1 - 2007/9

N2 - 1. In the present study, we investigated whether the administration of apocynin, an NADPH oxidase inhibitor, provided brain protection in a rat model of intracerebral haemorrhage (ICH). 2. Rats were divided into sham, ICH untreated, ICH treated with vehicle (ethanol) and ICH treated with apocynin groups. Intracerebral haemorrhage was induced by collagenase injection. Neurological function, haemorrhage volume and brain oedema were measured 24 h after ICH. 3. Intracerebral haemorrhage caused significant neurological deficit associated with brain oedema. Apocynin (3, 10 and 30 mg/kg) failed to reduce brain injury after ICH. Low dose ethanol (0.2 g/kg) improved neurological function and reduced brain oedema (ICH-vehicle vs ICH-untreated, P < 0.05). 4. In conclusion, apocynin has no neuroprotective effect when administered intraperitoneally after ICH.

AB - 1. In the present study, we investigated whether the administration of apocynin, an NADPH oxidase inhibitor, provided brain protection in a rat model of intracerebral haemorrhage (ICH). 2. Rats were divided into sham, ICH untreated, ICH treated with vehicle (ethanol) and ICH treated with apocynin groups. Intracerebral haemorrhage was induced by collagenase injection. Neurological function, haemorrhage volume and brain oedema were measured 24 h after ICH. 3. Intracerebral haemorrhage caused significant neurological deficit associated with brain oedema. Apocynin (3, 10 and 30 mg/kg) failed to reduce brain injury after ICH. Low dose ethanol (0.2 g/kg) improved neurological function and reduced brain oedema (ICH-vehicle vs ICH-untreated, P < 0.05). 4. In conclusion, apocynin has no neuroprotective effect when administered intraperitoneally after ICH.

KW - Apocynin

KW - Collagenase

KW - Ethanol

KW - Intracerebral haemorrhage

KW - Oedema

KW - Oxidative stress

UR - http://www.scopus.com/inward/record.url?scp=34447526348&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34447526348&partnerID=8YFLogxK

U2 - 10.1111/j.1440-1681.2007.04664.x

DO - 10.1111/j.1440-1681.2007.04664.x

M3 - Article

C2 - 17645627

AN - SCOPUS:34447526348

VL - 34

SP - 845

EP - 850

JO - Clinical and Experimental Pharmacology and Physiology

JF - Clinical and Experimental Pharmacology and Physiology

SN - 0305-1870

IS - 9

ER -