Effects of apocynin and ethanol on intracerebral haemorrhage-induced brain injury in rats

Elena Titova; Robert P. Ostrowski; Lawrence C. Sowers; John H. Zhang; Jiping Tang

doi:10.1111/j.1440-1681.2007.04664.x

Effects of apocynin and ethanol on intracerebral haemorrhage-induced brain injury in rats

Elena Titova, Robert P. Ostrowski, Lawrence C. Sowers, John H. Zhang, Jiping Tang

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

1. In the present study, we investigated whether the administration of apocynin, an NADPH oxidase inhibitor, provided brain protection in a rat model of intracerebral haemorrhage (ICH). 2. Rats were divided into sham, ICH untreated, ICH treated with vehicle (ethanol) and ICH treated with apocynin groups. Intracerebral haemorrhage was induced by collagenase injection. Neurological function, haemorrhage volume and brain oedema were measured 24 h after ICH. 3. Intracerebral haemorrhage caused significant neurological deficit associated with brain oedema. Apocynin (3, 10 and 30 mg/kg) failed to reduce brain injury after ICH. Low dose ethanol (0.2 g/kg) improved neurological function and reduced brain oedema (ICH-vehicle vs ICH-untreated, P < 0.05). 4. In conclusion, apocynin has no neuroprotective effect when administered intraperitoneally after ICH.

Original language	English (US)
Pages (from-to)	845-850
Number of pages	6
Journal	Clinical and Experimental Pharmacology and Physiology
Volume	34
Issue number	9
DOIs	https://doi.org/10.1111/j.1440-1681.2007.04664.x
State	Published - Sep 2007
Externally published	Yes

Keywords

Apocynin
Collagenase
Ethanol
Intracerebral haemorrhage
Oedema
Oxidative stress

ASJC Scopus subject areas

Physiology
Pharmacology
Physiology (medical)

Access to Document

10.1111/j.1440-1681.2007.04664.x

Cite this

@article{36ec7cd73f0a4e11b4b865675c3477b6,

title = "Effects of apocynin and ethanol on intracerebral haemorrhage-induced brain injury in rats",

abstract = "1. In the present study, we investigated whether the administration of apocynin, an NADPH oxidase inhibitor, provided brain protection in a rat model of intracerebral haemorrhage (ICH). 2. Rats were divided into sham, ICH untreated, ICH treated with vehicle (ethanol) and ICH treated with apocynin groups. Intracerebral haemorrhage was induced by collagenase injection. Neurological function, haemorrhage volume and brain oedema were measured 24 h after ICH. 3. Intracerebral haemorrhage caused significant neurological deficit associated with brain oedema. Apocynin (3, 10 and 30 mg/kg) failed to reduce brain injury after ICH. Low dose ethanol (0.2 g/kg) improved neurological function and reduced brain oedema (ICH-vehicle vs ICH-untreated, P < 0.05). 4. In conclusion, apocynin has no neuroprotective effect when administered intraperitoneally after ICH.",

keywords = "Apocynin, Collagenase, Ethanol, Intracerebral haemorrhage, Oedema, Oxidative stress",

author = "Elena Titova and Ostrowski, {Robert P.} and Sowers, {Lawrence C.} and Zhang, {John H.} and Jiping Tang",

year = "2007",

month = sep,

doi = "10.1111/j.1440-1681.2007.04664.x",

language = "English (US)",

volume = "34",

pages = "845--850",

journal = "Clinical and Experimental Pharmacology and Physiology",

issn = "0305-1870",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "9",

}

TY - JOUR

T1 - Effects of apocynin and ethanol on intracerebral haemorrhage-induced brain injury in rats

AU - Titova, Elena

AU - Ostrowski, Robert P.

AU - Sowers, Lawrence C.

AU - Zhang, John H.

AU - Tang, Jiping

PY - 2007/9

Y1 - 2007/9

N2 - 1. In the present study, we investigated whether the administration of apocynin, an NADPH oxidase inhibitor, provided brain protection in a rat model of intracerebral haemorrhage (ICH). 2. Rats were divided into sham, ICH untreated, ICH treated with vehicle (ethanol) and ICH treated with apocynin groups. Intracerebral haemorrhage was induced by collagenase injection. Neurological function, haemorrhage volume and brain oedema were measured 24 h after ICH. 3. Intracerebral haemorrhage caused significant neurological deficit associated with brain oedema. Apocynin (3, 10 and 30 mg/kg) failed to reduce brain injury after ICH. Low dose ethanol (0.2 g/kg) improved neurological function and reduced brain oedema (ICH-vehicle vs ICH-untreated, P < 0.05). 4. In conclusion, apocynin has no neuroprotective effect when administered intraperitoneally after ICH.

AB - 1. In the present study, we investigated whether the administration of apocynin, an NADPH oxidase inhibitor, provided brain protection in a rat model of intracerebral haemorrhage (ICH). 2. Rats were divided into sham, ICH untreated, ICH treated with vehicle (ethanol) and ICH treated with apocynin groups. Intracerebral haemorrhage was induced by collagenase injection. Neurological function, haemorrhage volume and brain oedema were measured 24 h after ICH. 3. Intracerebral haemorrhage caused significant neurological deficit associated with brain oedema. Apocynin (3, 10 and 30 mg/kg) failed to reduce brain injury after ICH. Low dose ethanol (0.2 g/kg) improved neurological function and reduced brain oedema (ICH-vehicle vs ICH-untreated, P < 0.05). 4. In conclusion, apocynin has no neuroprotective effect when administered intraperitoneally after ICH.

KW - Apocynin

KW - Collagenase

KW - Ethanol

KW - Intracerebral haemorrhage

KW - Oedema

KW - Oxidative stress

UR - http://www.scopus.com/inward/record.url?scp=34447526348&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34447526348&partnerID=8YFLogxK

U2 - 10.1111/j.1440-1681.2007.04664.x

DO - 10.1111/j.1440-1681.2007.04664.x

M3 - Article

C2 - 17645627

AN - SCOPUS:34447526348

SN - 0305-1870

VL - 34

SP - 845

EP - 850

JO - Clinical and Experimental Pharmacology and Physiology

JF - Clinical and Experimental Pharmacology and Physiology

IS - 9

ER -

Effects of apocynin and ethanol on intracerebral haemorrhage-induced brain injury in rats

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this