Effects of atorvastatin on secret inflammatory cytokine in peripheral blood mononuclear cells from essential hypertension patients

Fu Rong Pan, Qiangjun Cai, Ping Pan, Ke Jian Xie

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To investigate the effects of atorvastatin on secret inflammatory cytokine-tumor necrosis factor-alpha (TNF-α), interleukin-6( IL-6) and interleukin-1β(IL-1β) in peripheral blood mononuclear cells(PBMC) from essential hypertension (EH) patients. METHODS: Forty male patients with EH were divided randomly into two groups: atorvastatin therapeutic group (antihyper-tensive therapy + atorvastatin 10 mg·d-1 for 6 months) and conventional therapeutic group. The levels of TNF-α, IL-6 and IL-1β in PBMC were measured before and after 3 months. 20 age-and sex-matched healthy subjects served as controls. RESULTS: The TNF-α, IL-6 and IL-β levels of PBMC in EH patients were significantly higher than those of normal controls(P <0.01). TNF-α, IL-6 and IL-1β levels of PBMC after treatment were significantly lower than before in atorvastatin therapeutic group (P <0.05, P <0.01). There were not significant differences between before and after treatment in conventional therapeutic group (P >0.05). CONCLUSION: The activated PBMC may be involved in the pathogenesis of EH.

Original languageEnglish (US)
Pages (from-to)140-143
Number of pages4
JournalChinese Pharmaceutical Journal
Volume45
Issue number2
StatePublished - Jan 1 2010
Externally publishedYes

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Blood Cells
Cytokines
Interleukin-6
Tumor Necrosis Factor-alpha
Interleukin-1
Healthy Volunteers
Therapeutics
Atorvastatin Calcium
Essential Hypertension

Keywords

  • Atorvastatin
  • Essential hypertension
  • IL-1β
  • IL-6
  • Peripheral blood mononuclear cells
  • TNF-α

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

Cite this

Effects of atorvastatin on secret inflammatory cytokine in peripheral blood mononuclear cells from essential hypertension patients. / Pan, Fu Rong; Cai, Qiangjun; Pan, Ping; Xie, Ke Jian.

In: Chinese Pharmaceutical Journal, Vol. 45, No. 2, 01.01.2010, p. 140-143.

Research output: Contribution to journalArticle

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AU - Pan, Fu Rong

AU - Cai, Qiangjun

AU - Pan, Ping

AU - Xie, Ke Jian

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N2 - OBJECTIVE: To investigate the effects of atorvastatin on secret inflammatory cytokine-tumor necrosis factor-alpha (TNF-α), interleukin-6( IL-6) and interleukin-1β(IL-1β) in peripheral blood mononuclear cells(PBMC) from essential hypertension (EH) patients. METHODS: Forty male patients with EH were divided randomly into two groups: atorvastatin therapeutic group (antihyper-tensive therapy + atorvastatin 10 mg·d-1 for 6 months) and conventional therapeutic group. The levels of TNF-α, IL-6 and IL-1β in PBMC were measured before and after 3 months. 20 age-and sex-matched healthy subjects served as controls. RESULTS: The TNF-α, IL-6 and IL-β levels of PBMC in EH patients were significantly higher than those of normal controls(P <0.01). TNF-α, IL-6 and IL-1β levels of PBMC after treatment were significantly lower than before in atorvastatin therapeutic group (P <0.05, P <0.01). There were not significant differences between before and after treatment in conventional therapeutic group (P >0.05). CONCLUSION: The activated PBMC may be involved in the pathogenesis of EH.

AB - OBJECTIVE: To investigate the effects of atorvastatin on secret inflammatory cytokine-tumor necrosis factor-alpha (TNF-α), interleukin-6( IL-6) and interleukin-1β(IL-1β) in peripheral blood mononuclear cells(PBMC) from essential hypertension (EH) patients. METHODS: Forty male patients with EH were divided randomly into two groups: atorvastatin therapeutic group (antihyper-tensive therapy + atorvastatin 10 mg·d-1 for 6 months) and conventional therapeutic group. The levels of TNF-α, IL-6 and IL-1β in PBMC were measured before and after 3 months. 20 age-and sex-matched healthy subjects served as controls. RESULTS: The TNF-α, IL-6 and IL-β levels of PBMC in EH patients were significantly higher than those of normal controls(P <0.01). TNF-α, IL-6 and IL-1β levels of PBMC after treatment were significantly lower than before in atorvastatin therapeutic group (P <0.05, P <0.01). There were not significant differences between before and after treatment in conventional therapeutic group (P >0.05). CONCLUSION: The activated PBMC may be involved in the pathogenesis of EH.

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