Effects of atractyloside and palmitoyl coenzyme A on calcium transport in cardiac mitochondria

G. K. Asimakis, Louis A. Sordahl

    Research output: Contribution to journalArticlepeer-review

    50 Scopus citations


    Palmitoyl CoA (PCoA) and the adenine translocase inhibitor atractyloside (ATR) appear to produce a similar effect in discharging accumulated calcium from cardiac mitochondria. Although mitochondrial respiration is stimulated upon addition of either PCoA or ATR to preparations preloaded with calcium, the effect is not the same as that produced by classical uncouplers. PCoA and ATR also do not interfere with respiration-supported calcium uptake by mitochondria. The presence of exogenous ATP can prevent the calcium discharging effects of PCoA or ATR. Carnitine will prevent the PCoA calcium discharging effect, but has no effect on ATR-induced discharge. It is suggested the PCoA may act at a site on or near the adenine translocase, perhaps through allosteric interaction, to produce an efflux of calcium from mitochondria. The results also suggest that the internal adenine nucleotide pool plays a significant role in mitochondrial calcium retention.

    Original languageEnglish (US)
    Pages (from-to)200-210
    Number of pages11
    JournalArchives of Biochemistry and Biophysics
    Issue number1
    StatePublished - Feb 1977

    ASJC Scopus subject areas

    • Biophysics
    • Biochemistry
    • Molecular Biology


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