Effects of bombesin on growth of human small cell lung carcinoma in vivo

R. W. Alexander, J. R. Upp, G. J. Poston, V. Gupta, Courtney Townsend, J. C. Thompson

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Bombesin-like peptides are found in many different human tumors and are thought to function as an autocrine growth factor for small cell lung cancer in humans. In this study, a human small cell lung carcinoma (NCI-H69) was s.c. implanted bilaterally into the flanks of 12 nude mice. The mice were randomized an divided into two groups and given either bombesin (20 μg/kg) or saline i.p. 3 times a day. Tumor areas were measured twice weekly for 6 wk. At sacrifice, the tumors and noromal pancreas were excised, weighed, and assayed for DNA, RNA, and protein content. Significant stimulation of tumor growth was observed at weeks 4, 5, and 6. Tumor weight at sacrifice was significantly elevated (77%) above the control, as was DNA content (78%). Bombesin significantly increased the weight (42%), DNA (48%), and protein (61%) contents of the normal mouse pancreas. We conclude that bombesin may act as an autocrine growth factor, or indirectly through the release of other growth factors, on human small cell lung carcinoma.

Original languageEnglish (US)
Pages (from-to)1439-1441
Number of pages3
JournalCancer Research
Volume48
Issue number6
StatePublished - 1988

Fingerprint

Bombesin
Small Cell Lung Carcinoma
Intercellular Signaling Peptides and Proteins
Growth
Pancreas
DNA
Neoplasms
Tumor Burden
Nude Mice
Proteins
RNA
Weights and Measures
Peptides

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Alexander, R. W., Upp, J. R., Poston, G. J., Gupta, V., Townsend, C., & Thompson, J. C. (1988). Effects of bombesin on growth of human small cell lung carcinoma in vivo. Cancer Research, 48(6), 1439-1441.

Effects of bombesin on growth of human small cell lung carcinoma in vivo. / Alexander, R. W.; Upp, J. R.; Poston, G. J.; Gupta, V.; Townsend, Courtney; Thompson, J. C.

In: Cancer Research, Vol. 48, No. 6, 1988, p. 1439-1441.

Research output: Contribution to journalArticle

Alexander, RW, Upp, JR, Poston, GJ, Gupta, V, Townsend, C & Thompson, JC 1988, 'Effects of bombesin on growth of human small cell lung carcinoma in vivo', Cancer Research, vol. 48, no. 6, pp. 1439-1441.
Alexander RW, Upp JR, Poston GJ, Gupta V, Townsend C, Thompson JC. Effects of bombesin on growth of human small cell lung carcinoma in vivo. Cancer Research. 1988;48(6):1439-1441.
Alexander, R. W. ; Upp, J. R. ; Poston, G. J. ; Gupta, V. ; Townsend, Courtney ; Thompson, J. C. / Effects of bombesin on growth of human small cell lung carcinoma in vivo. In: Cancer Research. 1988 ; Vol. 48, No. 6. pp. 1439-1441.
@article{f4a7ac3a74ec48368149013e604ad97d,
title = "Effects of bombesin on growth of human small cell lung carcinoma in vivo",
abstract = "Bombesin-like peptides are found in many different human tumors and are thought to function as an autocrine growth factor for small cell lung cancer in humans. In this study, a human small cell lung carcinoma (NCI-H69) was s.c. implanted bilaterally into the flanks of 12 nude mice. The mice were randomized an divided into two groups and given either bombesin (20 μg/kg) or saline i.p. 3 times a day. Tumor areas were measured twice weekly for 6 wk. At sacrifice, the tumors and noromal pancreas were excised, weighed, and assayed for DNA, RNA, and protein content. Significant stimulation of tumor growth was observed at weeks 4, 5, and 6. Tumor weight at sacrifice was significantly elevated (77{\%}) above the control, as was DNA content (78{\%}). Bombesin significantly increased the weight (42{\%}), DNA (48{\%}), and protein (61{\%}) contents of the normal mouse pancreas. We conclude that bombesin may act as an autocrine growth factor, or indirectly through the release of other growth factors, on human small cell lung carcinoma.",
author = "Alexander, {R. W.} and Upp, {J. R.} and Poston, {G. J.} and V. Gupta and Courtney Townsend and Thompson, {J. C.}",
year = "1988",
language = "English (US)",
volume = "48",
pages = "1439--1441",
journal = "Journal of Cancer Research",
issn = "0008-5472",
publisher = "American Association for Cancer Research Inc.",
number = "6",

}

TY - JOUR

T1 - Effects of bombesin on growth of human small cell lung carcinoma in vivo

AU - Alexander, R. W.

AU - Upp, J. R.

AU - Poston, G. J.

AU - Gupta, V.

AU - Townsend, Courtney

AU - Thompson, J. C.

PY - 1988

Y1 - 1988

N2 - Bombesin-like peptides are found in many different human tumors and are thought to function as an autocrine growth factor for small cell lung cancer in humans. In this study, a human small cell lung carcinoma (NCI-H69) was s.c. implanted bilaterally into the flanks of 12 nude mice. The mice were randomized an divided into two groups and given either bombesin (20 μg/kg) or saline i.p. 3 times a day. Tumor areas were measured twice weekly for 6 wk. At sacrifice, the tumors and noromal pancreas were excised, weighed, and assayed for DNA, RNA, and protein content. Significant stimulation of tumor growth was observed at weeks 4, 5, and 6. Tumor weight at sacrifice was significantly elevated (77%) above the control, as was DNA content (78%). Bombesin significantly increased the weight (42%), DNA (48%), and protein (61%) contents of the normal mouse pancreas. We conclude that bombesin may act as an autocrine growth factor, or indirectly through the release of other growth factors, on human small cell lung carcinoma.

AB - Bombesin-like peptides are found in many different human tumors and are thought to function as an autocrine growth factor for small cell lung cancer in humans. In this study, a human small cell lung carcinoma (NCI-H69) was s.c. implanted bilaterally into the flanks of 12 nude mice. The mice were randomized an divided into two groups and given either bombesin (20 μg/kg) or saline i.p. 3 times a day. Tumor areas were measured twice weekly for 6 wk. At sacrifice, the tumors and noromal pancreas were excised, weighed, and assayed for DNA, RNA, and protein content. Significant stimulation of tumor growth was observed at weeks 4, 5, and 6. Tumor weight at sacrifice was significantly elevated (77%) above the control, as was DNA content (78%). Bombesin significantly increased the weight (42%), DNA (48%), and protein (61%) contents of the normal mouse pancreas. We conclude that bombesin may act as an autocrine growth factor, or indirectly through the release of other growth factors, on human small cell lung carcinoma.

UR - http://www.scopus.com/inward/record.url?scp=0023902829&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023902829&partnerID=8YFLogxK

M3 - Article

C2 - 2830965

AN - SCOPUS:0023902829

VL - 48

SP - 1439

EP - 1441

JO - Journal of Cancer Research

JF - Journal of Cancer Research

SN - 0008-5472

IS - 6

ER -