Effects of calcium channel blockade on calcium homeostasis in mild to moderate essential hypertension

R. Townsend, D. J. Dipette, R. R. Evans, W. R. Davis, A. Green, G. A. Graham, J. M. Wallace, O. B. Holland

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Calcium channel blockers may alter parathyroid hormone secretion in vitro, which would alter calcium homeostasis. To determine the chronic effect of calcium channel blockade in vivo, we conducted a randomized, double blind, 16 week study comparing the effects of two pharmacologic antihypertensive agents, the calcium channel blocker diltiazem and the angiotensin-converting enzyme inhibitor captopril on parameters of calcium homeostasis. Both diltiazem and captopril lowered blood pressure to a similar degree. Neither drug produced any significant change in blood levels of total and ionized calcium, magnesium, or phosphorus, which affect the regulation of parathyroid hormone and vitamin D. In addition, at eight or 16 weeks following initiation, neither drug altered the serum levels of parathyroid hormone (PTH) or 1,25-(OH)2-vitamin D3 (1,25-D). Chronic calcium channel blockade with diltiazem does not alter serum parameters of calcium homeostasis and, thus, should not affect bone mineralization.

Original languageEnglish (US)
Pages (from-to)133-137
Number of pages5
JournalAmerican Journal of the Medical Sciences
Volume300
Issue number3
StatePublished - 1990

Fingerprint

Calcium Channels
Diltiazem
Homeostasis
Parathyroid Hormone
Calcium
Captopril
Calcium Channel Blockers
Physiologic Calcification
Cholecalciferol
Serum
Angiotensin-Converting Enzyme Inhibitors
Vitamin D
Pharmaceutical Preparations
Phosphorus
Magnesium
Antihypertensive Agents
Blood Pressure
Essential Hypertension

Keywords

  • Calcium channel blockers
  • Captopril
  • Diltiazem
  • Parathyroid hormone Vitamin D

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Townsend, R., Dipette, D. J., Evans, R. R., Davis, W. R., Green, A., Graham, G. A., ... Holland, O. B. (1990). Effects of calcium channel blockade on calcium homeostasis in mild to moderate essential hypertension. American Journal of the Medical Sciences, 300(3), 133-137.

Effects of calcium channel blockade on calcium homeostasis in mild to moderate essential hypertension. / Townsend, R.; Dipette, D. J.; Evans, R. R.; Davis, W. R.; Green, A.; Graham, G. A.; Wallace, J. M.; Holland, O. B.

In: American Journal of the Medical Sciences, Vol. 300, No. 3, 1990, p. 133-137.

Research output: Contribution to journalArticle

Townsend, R, Dipette, DJ, Evans, RR, Davis, WR, Green, A, Graham, GA, Wallace, JM & Holland, OB 1990, 'Effects of calcium channel blockade on calcium homeostasis in mild to moderate essential hypertension', American Journal of the Medical Sciences, vol. 300, no. 3, pp. 133-137.
Townsend R, Dipette DJ, Evans RR, Davis WR, Green A, Graham GA et al. Effects of calcium channel blockade on calcium homeostasis in mild to moderate essential hypertension. American Journal of the Medical Sciences. 1990;300(3):133-137.
Townsend, R. ; Dipette, D. J. ; Evans, R. R. ; Davis, W. R. ; Green, A. ; Graham, G. A. ; Wallace, J. M. ; Holland, O. B. / Effects of calcium channel blockade on calcium homeostasis in mild to moderate essential hypertension. In: American Journal of the Medical Sciences. 1990 ; Vol. 300, No. 3. pp. 133-137.
@article{0fff7ad083e44da188b5582c5dcf646e,
title = "Effects of calcium channel blockade on calcium homeostasis in mild to moderate essential hypertension",
abstract = "Calcium channel blockers may alter parathyroid hormone secretion in vitro, which would alter calcium homeostasis. To determine the chronic effect of calcium channel blockade in vivo, we conducted a randomized, double blind, 16 week study comparing the effects of two pharmacologic antihypertensive agents, the calcium channel blocker diltiazem and the angiotensin-converting enzyme inhibitor captopril on parameters of calcium homeostasis. Both diltiazem and captopril lowered blood pressure to a similar degree. Neither drug produced any significant change in blood levels of total and ionized calcium, magnesium, or phosphorus, which affect the regulation of parathyroid hormone and vitamin D. In addition, at eight or 16 weeks following initiation, neither drug altered the serum levels of parathyroid hormone (PTH) or 1,25-(OH)2-vitamin D3 (1,25-D). Chronic calcium channel blockade with diltiazem does not alter serum parameters of calcium homeostasis and, thus, should not affect bone mineralization.",
keywords = "Calcium channel blockers, Captopril, Diltiazem, Parathyroid hormone Vitamin D",
author = "R. Townsend and Dipette, {D. J.} and Evans, {R. R.} and Davis, {W. R.} and A. Green and Graham, {G. A.} and Wallace, {J. M.} and Holland, {O. B.}",
year = "1990",
language = "English (US)",
volume = "300",
pages = "133--137",
journal = "American Journal of the Medical Sciences",
issn = "0002-9629",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Effects of calcium channel blockade on calcium homeostasis in mild to moderate essential hypertension

AU - Townsend, R.

AU - Dipette, D. J.

AU - Evans, R. R.

AU - Davis, W. R.

AU - Green, A.

AU - Graham, G. A.

AU - Wallace, J. M.

AU - Holland, O. B.

PY - 1990

Y1 - 1990

N2 - Calcium channel blockers may alter parathyroid hormone secretion in vitro, which would alter calcium homeostasis. To determine the chronic effect of calcium channel blockade in vivo, we conducted a randomized, double blind, 16 week study comparing the effects of two pharmacologic antihypertensive agents, the calcium channel blocker diltiazem and the angiotensin-converting enzyme inhibitor captopril on parameters of calcium homeostasis. Both diltiazem and captopril lowered blood pressure to a similar degree. Neither drug produced any significant change in blood levels of total and ionized calcium, magnesium, or phosphorus, which affect the regulation of parathyroid hormone and vitamin D. In addition, at eight or 16 weeks following initiation, neither drug altered the serum levels of parathyroid hormone (PTH) or 1,25-(OH)2-vitamin D3 (1,25-D). Chronic calcium channel blockade with diltiazem does not alter serum parameters of calcium homeostasis and, thus, should not affect bone mineralization.

AB - Calcium channel blockers may alter parathyroid hormone secretion in vitro, which would alter calcium homeostasis. To determine the chronic effect of calcium channel blockade in vivo, we conducted a randomized, double blind, 16 week study comparing the effects of two pharmacologic antihypertensive agents, the calcium channel blocker diltiazem and the angiotensin-converting enzyme inhibitor captopril on parameters of calcium homeostasis. Both diltiazem and captopril lowered blood pressure to a similar degree. Neither drug produced any significant change in blood levels of total and ionized calcium, magnesium, or phosphorus, which affect the regulation of parathyroid hormone and vitamin D. In addition, at eight or 16 weeks following initiation, neither drug altered the serum levels of parathyroid hormone (PTH) or 1,25-(OH)2-vitamin D3 (1,25-D). Chronic calcium channel blockade with diltiazem does not alter serum parameters of calcium homeostasis and, thus, should not affect bone mineralization.

KW - Calcium channel blockers

KW - Captopril

KW - Diltiazem

KW - Parathyroid hormone Vitamin D

UR - http://www.scopus.com/inward/record.url?scp=0025066244&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025066244&partnerID=8YFLogxK

M3 - Article

VL - 300

SP - 133

EP - 137

JO - American Journal of the Medical Sciences

JF - American Journal of the Medical Sciences

SN - 0002-9629

IS - 3

ER -