TY - JOUR
T1 - Effects of calcium channel blockade on calcium homeostasis in mild to moderate essential hypertension
AU - Townsend, R.
AU - Dipette, D. J.
AU - Evans, R. R.
AU - Davis, W. R.
AU - Green, A.
AU - Graham, G. A.
AU - Wallace, J. M.
AU - Holland, O. B.
PY - 1990
Y1 - 1990
N2 - Calcium channel blockers may alter parathyroid hormone secretion in vitro, which would alter calcium homeostasis. To determine the chronic effect of calcium channel blockade in vivo, we conducted a randomized, double blind, 16 week study comparing the effects of two pharmacologic antihypertensive agents, the calcium channel blocker diltiazem and the angiotensin-converting enzyme inhibitor captopril on parameters of calcium homeostasis. Both diltiazem and captopril lowered blood pressure to a similar degree. Neither drug produced any significant change in blood levels of total and ionized calcium, magnesium, or phosphorus, which affect the regulation of parathyroid hormone and vitamin D. In addition, at eight or 16 weeks following initiation, neither drug altered the serum levels of parathyroid hormone (PTH) or 1,25-(OH)2-vitamin D3 (1,25-D). Chronic calcium channel blockade with diltiazem does not alter serum parameters of calcium homeostasis and, thus, should not affect bone mineralization.
AB - Calcium channel blockers may alter parathyroid hormone secretion in vitro, which would alter calcium homeostasis. To determine the chronic effect of calcium channel blockade in vivo, we conducted a randomized, double blind, 16 week study comparing the effects of two pharmacologic antihypertensive agents, the calcium channel blocker diltiazem and the angiotensin-converting enzyme inhibitor captopril on parameters of calcium homeostasis. Both diltiazem and captopril lowered blood pressure to a similar degree. Neither drug produced any significant change in blood levels of total and ionized calcium, magnesium, or phosphorus, which affect the regulation of parathyroid hormone and vitamin D. In addition, at eight or 16 weeks following initiation, neither drug altered the serum levels of parathyroid hormone (PTH) or 1,25-(OH)2-vitamin D3 (1,25-D). Chronic calcium channel blockade with diltiazem does not alter serum parameters of calcium homeostasis and, thus, should not affect bone mineralization.
KW - Calcium channel blockers
KW - Captopril
KW - Diltiazem
KW - Parathyroid hormone Vitamin D
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U2 - 10.1097/00000441-199009000-00001
DO - 10.1097/00000441-199009000-00001
M3 - Article
C2 - 2240002
AN - SCOPUS:0025066244
SN - 0002-9629
VL - 300
SP - 133
EP - 137
JO - American Journal of the Medical Sciences
JF - American Journal of the Medical Sciences
IS - 3
ER -