Effects of chloroquine in hematoporphyrin-treated animals

Norman G. Egger, Douglas E. Goeger, Karl Anderson

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Porphyrins and related compounds are useful in photodynamic therapy but can cause cutaneous photosensitivity. We determined whether chloroquine, which is effective in treating porphyria cutanea tarda, would mobilize an administered porphyrin from tissues and enhance its excretion. Hematoporphyrin with and without chloroquine was administered to chick embryos, mice, and rats. Tissue and plasma porphyrin levels were markedly increased after hematoporphyrin dosing. Porphyrin concentrations in liver, spleen, and kidney were not significantly affected by chloroquine. Total urinary and fecal porphyrin excretion in rats treated with hematoporphyrin (50 mg/kg, i.p.) was not influenced by chloroquine treatment (100 mg/kg, s.c.). Excretion of heptacarboxylporphyrin, normally a minor fraction of urinary porphyrins, was significantly increased in chloroquine-treated rats. These results suggest that chloroquine is unlikely to be useful after photodynamic therapy for mobilizing exogenous porphyrins from tissues such as liver, spleen, and kidney. Increased urinary excretion of heptacarboxylporphyrin may contribute to the beneficial effect of chloroquine in porphyria cutanea tarda.

Original languageEnglish (US)
Pages (from-to)69-78
Number of pages10
JournalChemico-Biological Interactions
Volume102
Issue number2
DOIs
StatePublished - Oct 21 1996

Fingerprint

Hematoporphyrins
Porphyrins
Chloroquine
Animals
Porphyria Cutanea Tarda
Rats
Photodynamic therapy
Photochemotherapy
Tissue
Liver
Spleen
Kidney
Photosensitivity
Chick Embryo
Plasmas
Skin

Keywords

  • Chloroquine
  • Hematoporphyrin
  • Photodynamic therapy
  • Porphyria
  • Porphyrins

ASJC Scopus subject areas

  • Toxicology

Cite this

Effects of chloroquine in hematoporphyrin-treated animals. / Egger, Norman G.; Goeger, Douglas E.; Anderson, Karl.

In: Chemico-Biological Interactions, Vol. 102, No. 2, 21.10.1996, p. 69-78.

Research output: Contribution to journalArticle

Egger, Norman G. ; Goeger, Douglas E. ; Anderson, Karl. / Effects of chloroquine in hematoporphyrin-treated animals. In: Chemico-Biological Interactions. 1996 ; Vol. 102, No. 2. pp. 69-78.
@article{e4d5e0e7a37f4ea1b5d5df15173c0b63,
title = "Effects of chloroquine in hematoporphyrin-treated animals",
abstract = "Porphyrins and related compounds are useful in photodynamic therapy but can cause cutaneous photosensitivity. We determined whether chloroquine, which is effective in treating porphyria cutanea tarda, would mobilize an administered porphyrin from tissues and enhance its excretion. Hematoporphyrin with and without chloroquine was administered to chick embryos, mice, and rats. Tissue and plasma porphyrin levels were markedly increased after hematoporphyrin dosing. Porphyrin concentrations in liver, spleen, and kidney were not significantly affected by chloroquine. Total urinary and fecal porphyrin excretion in rats treated with hematoporphyrin (50 mg/kg, i.p.) was not influenced by chloroquine treatment (100 mg/kg, s.c.). Excretion of heptacarboxylporphyrin, normally a minor fraction of urinary porphyrins, was significantly increased in chloroquine-treated rats. These results suggest that chloroquine is unlikely to be useful after photodynamic therapy for mobilizing exogenous porphyrins from tissues such as liver, spleen, and kidney. Increased urinary excretion of heptacarboxylporphyrin may contribute to the beneficial effect of chloroquine in porphyria cutanea tarda.",
keywords = "Chloroquine, Hematoporphyrin, Photodynamic therapy, Porphyria, Porphyrins",
author = "Egger, {Norman G.} and Goeger, {Douglas E.} and Karl Anderson",
year = "1996",
month = "10",
day = "21",
doi = "10.1016/S0009-2797(96)03732-5",
language = "English (US)",
volume = "102",
pages = "69--78",
journal = "Chemico-Biological Interactions",
issn = "0009-2797",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Effects of chloroquine in hematoporphyrin-treated animals

AU - Egger, Norman G.

AU - Goeger, Douglas E.

AU - Anderson, Karl

PY - 1996/10/21

Y1 - 1996/10/21

N2 - Porphyrins and related compounds are useful in photodynamic therapy but can cause cutaneous photosensitivity. We determined whether chloroquine, which is effective in treating porphyria cutanea tarda, would mobilize an administered porphyrin from tissues and enhance its excretion. Hematoporphyrin with and without chloroquine was administered to chick embryos, mice, and rats. Tissue and plasma porphyrin levels were markedly increased after hematoporphyrin dosing. Porphyrin concentrations in liver, spleen, and kidney were not significantly affected by chloroquine. Total urinary and fecal porphyrin excretion in rats treated with hematoporphyrin (50 mg/kg, i.p.) was not influenced by chloroquine treatment (100 mg/kg, s.c.). Excretion of heptacarboxylporphyrin, normally a minor fraction of urinary porphyrins, was significantly increased in chloroquine-treated rats. These results suggest that chloroquine is unlikely to be useful after photodynamic therapy for mobilizing exogenous porphyrins from tissues such as liver, spleen, and kidney. Increased urinary excretion of heptacarboxylporphyrin may contribute to the beneficial effect of chloroquine in porphyria cutanea tarda.

AB - Porphyrins and related compounds are useful in photodynamic therapy but can cause cutaneous photosensitivity. We determined whether chloroquine, which is effective in treating porphyria cutanea tarda, would mobilize an administered porphyrin from tissues and enhance its excretion. Hematoporphyrin with and without chloroquine was administered to chick embryos, mice, and rats. Tissue and plasma porphyrin levels were markedly increased after hematoporphyrin dosing. Porphyrin concentrations in liver, spleen, and kidney were not significantly affected by chloroquine. Total urinary and fecal porphyrin excretion in rats treated with hematoporphyrin (50 mg/kg, i.p.) was not influenced by chloroquine treatment (100 mg/kg, s.c.). Excretion of heptacarboxylporphyrin, normally a minor fraction of urinary porphyrins, was significantly increased in chloroquine-treated rats. These results suggest that chloroquine is unlikely to be useful after photodynamic therapy for mobilizing exogenous porphyrins from tissues such as liver, spleen, and kidney. Increased urinary excretion of heptacarboxylporphyrin may contribute to the beneficial effect of chloroquine in porphyria cutanea tarda.

KW - Chloroquine

KW - Hematoporphyrin

KW - Photodynamic therapy

KW - Porphyria

KW - Porphyrins

UR - http://www.scopus.com/inward/record.url?scp=0030597040&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030597040&partnerID=8YFLogxK

U2 - 10.1016/S0009-2797(96)03732-5

DO - 10.1016/S0009-2797(96)03732-5

M3 - Article

VL - 102

SP - 69

EP - 78

JO - Chemico-Biological Interactions

JF - Chemico-Biological Interactions

SN - 0009-2797

IS - 2

ER -