Effects of cholera toxin on small intestinal motor activity in the fasted state

V. E. Cowles, S. K. Sarna

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We sought to determine the effect of cholera toxin on small intestinal motor activity in the fasted state and relate it to secretion in conscious dogs. Motor activity was recorded by strain gauge force transducers and secretion was measured by diverting it to the outside through a two-way cannula. Inoculation of the study segment with cholera toxin resulted in a 10-fold increase in fluid output by 120 minutes postinjection. At the same time that fluid output increased significantly changes in fasting motor activity occurred. The cycle length of the migrating motor complex was significantly reduced, the perceutage of phase II activity was significantly increased, and migrating clustered contractions were inhibited. Perfusion of the study segment by a nonabsorbable electrolyte solution at a rate similar to the rate of secretion induced by cholera toxin did not change the cycle length of migrating motor complexes, but the percentage of phase II activity was significantly increased as with cholera toxin, and migrating clustered contractions were inhibited. The reduction in the cycle length of migrating motor complexes seems to be a direct effect of cholera toxin on the gut wall while the increase in percentage of phase II activity and inhibition of migrating clustered contractions appear to be indirect effects due to fluid accumulation.

Original languageEnglish (US)
Pages (from-to)90-98
Number of pages9
JournalJournal of Gastrointestinal Motility
Volume1
Issue number2
StatePublished - 1989
Externally publishedYes

Fingerprint

Cholera Toxin
Migrating Myoelectric Complexes
Motor Activity
Transducers
Electrolytes
Fasting
Perfusion
Dogs

Keywords

  • diarrhea
  • giant migrating contraction
  • migrating clustered contractions
  • migrating motor complex
  • motility
  • retrograde giant contraction

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Cite this

Effects of cholera toxin on small intestinal motor activity in the fasted state. / Cowles, V. E.; Sarna, S. K.

In: Journal of Gastrointestinal Motility, Vol. 1, No. 2, 1989, p. 90-98.

Research output: Contribution to journalArticle

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