Abstract
We sought to determine the effect of cholera toxin on small intestinal motor activity in the fasted state and relate it to secretion in conscious dogs. Motor activity was recorded by strain gauge force transducers and secretion was measured by diverting it to the outside through a two‐way cannula. Inoculation of the study segment with cholera toxin resulted in a 10‐fold increase in fluid output by 120 minutes postinjection. At the same time that fluid output increased Significantly changes in fasting motor activity occurred. The cycle length of the migrating motor complex was significantly reduced, the percentage of phase II activity was significantly increased, and migrating clustered contractions were inhibited. Perfusion of the study segment by a nonabsorbable electrolyte solution at a rate similar to the rate of secretion induced by cholera toxin did not change the cycle length of migrating motor complexes, but the percentage of phase II activity was significantly increased as with cholera toxin, and migrating clustered contractions were inhibited. The reduction in the cycle length of migrating motor complexes seems to be a direct effect of cholera toxin on the gut wall while the increase in percentage of phase II activity and inhibition of migrating clustered contractions appear to be indirect effects due to fluid accumulation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 90-98 |
| Number of pages | 9 |
| Journal | Neurogastroenterology and Motility |
| Volume | 1 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1989 |
| Externally published | Yes |
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Keywords
- diarrhea
- giant migrating contraction
- migrating clustered contractions
- Migrating motor complex
- motility
- retrograde giant contraction
ASJC Scopus subject areas
- Physiology
- Endocrine and Autonomic Systems
- Gastroenterology
Cite this
Effects of Cholera Toxin on Small Intestinal Motor Activity in the Fasted State. / Cowles, Verne E.; Sarna, Sushil K.
In: Neurogastroenterology and Motility, Vol. 1, No. 2, 1989, p. 90-98.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of Cholera Toxin on Small Intestinal Motor Activity in the Fasted State
AU - Cowles, Verne E.
AU - Sarna, Sushil K.
PY - 1989
Y1 - 1989
N2 - We sought to determine the effect of cholera toxin on small intestinal motor activity in the fasted state and relate it to secretion in conscious dogs. Motor activity was recorded by strain gauge force transducers and secretion was measured by diverting it to the outside through a two‐way cannula. Inoculation of the study segment with cholera toxin resulted in a 10‐fold increase in fluid output by 120 minutes postinjection. At the same time that fluid output increased Significantly changes in fasting motor activity occurred. The cycle length of the migrating motor complex was significantly reduced, the percentage of phase II activity was significantly increased, and migrating clustered contractions were inhibited. Perfusion of the study segment by a nonabsorbable electrolyte solution at a rate similar to the rate of secretion induced by cholera toxin did not change the cycle length of migrating motor complexes, but the percentage of phase II activity was significantly increased as with cholera toxin, and migrating clustered contractions were inhibited. The reduction in the cycle length of migrating motor complexes seems to be a direct effect of cholera toxin on the gut wall while the increase in percentage of phase II activity and inhibition of migrating clustered contractions appear to be indirect effects due to fluid accumulation.
AB - We sought to determine the effect of cholera toxin on small intestinal motor activity in the fasted state and relate it to secretion in conscious dogs. Motor activity was recorded by strain gauge force transducers and secretion was measured by diverting it to the outside through a two‐way cannula. Inoculation of the study segment with cholera toxin resulted in a 10‐fold increase in fluid output by 120 minutes postinjection. At the same time that fluid output increased Significantly changes in fasting motor activity occurred. The cycle length of the migrating motor complex was significantly reduced, the percentage of phase II activity was significantly increased, and migrating clustered contractions were inhibited. Perfusion of the study segment by a nonabsorbable electrolyte solution at a rate similar to the rate of secretion induced by cholera toxin did not change the cycle length of migrating motor complexes, but the percentage of phase II activity was significantly increased as with cholera toxin, and migrating clustered contractions were inhibited. The reduction in the cycle length of migrating motor complexes seems to be a direct effect of cholera toxin on the gut wall while the increase in percentage of phase II activity and inhibition of migrating clustered contractions appear to be indirect effects due to fluid accumulation.
KW - diarrhea
KW - giant migrating contraction
KW - migrating clustered contractions
KW - Migrating motor complex
KW - motility
KW - retrograde giant contraction
UR - http://www.scopus.com/inward/record.url?scp=84994926344&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84994926344&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2982.1989.tb00146.x
DO - 10.1111/j.1365-2982.1989.tb00146.x
M3 - Article
AN - SCOPUS:84994926344
VL - 1
SP - 90
EP - 98
JO - Neurogastroenterology and Motility
JF - Neurogastroenterology and Motility
SN - 1350-1925
IS - 2
ER -