Effects of coronary revascularization with or without cardiopulmonary bypass on plasma levels of asymmetric dimethylarginine

Attila Cziráki, Zénó Ajtay, Ádám Németh, Zsófia Lenkey, Endre Sulyok, Sándor Szabados, Nasri Alotti, Jens Martens-Lobenhoffer, Csaba Szabo, Stefanie M. Bode-Böger

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objectives: We measured and compared serum asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), and L-arginine levels in patients undergoing coronary artery revascularization. Methods: Two groups of patients with coronary artery disease were subjected to coronary artery bypass graft surgery (CABG) with cardiopulmonary bypass (CPB; n=20) or with off-pump CABG surgery (OPCABG; n=21). Blood samples for measurements of ADMA, SDMA, and L-arginine were withdrawn and determined by liquid chromatography-tandem mass spectrometry from the coronary sinus (CS) and from the peripheral vein. Results: On the basis of the intraoperative (CS) samples, ADMA levels rose in the CPB group (F=0.416, P<0.685 and F=14.751, P<0.001 for OPCABG and CPB groups, respectively). A similar significant increase of ADMA was observed in the peripheral blood (F=30.738, P<0.001) during CPB, whereas ADMA levels remained unchanged during OPCABG. The time course of L-arginine levels was significantly different in the blood samples from CS (F=3.255, P<0.05), when compared with samples from the peripheral blood (F=3.255, P<0.05). The values of the L-arginine/ADMA ratio were significantly higher in the OPCABG group at baseline and on the first postoperative day compared with the results of the CPB group (178.29±11.56 vs. 136.28±13.72 and 129.43±7.08 vs. 106.8±6.9 for OPCABG and CPB groups, respectively). Conclusion: Plasma levels of ADMA, SDMA, L-arginine, and L-arginine/ADMA ratio are reliable and feasible markers of an early ischemia-reperfusion injury. During CPB operation, the plasma concentration of ADMA increased significantly and remained elevated until the first postoperative day due to extensive ischemia-reperfusion injury caused by CPB.

Original languageEnglish (US)
Pages (from-to)245-252
Number of pages8
JournalCoronary Artery Disease
Volume22
Issue number4
DOIs
StatePublished - Jun 2011

Fingerprint

Cardiopulmonary Bypass
Arginine
Coronary Sinus
Reperfusion Injury
Coronary Artery Bypass
Off-Pump Coronary Artery Bypass
Transplants
N,N-dimethylarginine
Tandem Mass Spectrometry
Liquid Chromatography
Coronary Artery Disease
Veins
Coronary Vessels
Serum

Keywords

  • Asymmetric dimethylarginine
  • coronary heart disease
  • revascularization

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Cziráki, A., Ajtay, Z., Németh, Á., Lenkey, Z., Sulyok, E., Szabados, S., ... Bode-Böger, S. M. (2011). Effects of coronary revascularization with or without cardiopulmonary bypass on plasma levels of asymmetric dimethylarginine. Coronary Artery Disease, 22(4), 245-252. https://doi.org/10.1097/MCA.0b013e3283441d5c

Effects of coronary revascularization with or without cardiopulmonary bypass on plasma levels of asymmetric dimethylarginine. / Cziráki, Attila; Ajtay, Zénó; Németh, Ádám; Lenkey, Zsófia; Sulyok, Endre; Szabados, Sándor; Alotti, Nasri; Martens-Lobenhoffer, Jens; Szabo, Csaba; Bode-Böger, Stefanie M.

In: Coronary Artery Disease, Vol. 22, No. 4, 06.2011, p. 245-252.

Research output: Contribution to journalArticle

Cziráki, A, Ajtay, Z, Németh, Á, Lenkey, Z, Sulyok, E, Szabados, S, Alotti, N, Martens-Lobenhoffer, J, Szabo, C & Bode-Böger, SM 2011, 'Effects of coronary revascularization with or without cardiopulmonary bypass on plasma levels of asymmetric dimethylarginine', Coronary Artery Disease, vol. 22, no. 4, pp. 245-252. https://doi.org/10.1097/MCA.0b013e3283441d5c
Cziráki, Attila ; Ajtay, Zénó ; Németh, Ádám ; Lenkey, Zsófia ; Sulyok, Endre ; Szabados, Sándor ; Alotti, Nasri ; Martens-Lobenhoffer, Jens ; Szabo, Csaba ; Bode-Böger, Stefanie M. / Effects of coronary revascularization with or without cardiopulmonary bypass on plasma levels of asymmetric dimethylarginine. In: Coronary Artery Disease. 2011 ; Vol. 22, No. 4. pp. 245-252.
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AU - Cziráki, Attila

AU - Ajtay, Zénó

AU - Németh, Ádám

AU - Lenkey, Zsófia

AU - Sulyok, Endre

AU - Szabados, Sándor

AU - Alotti, Nasri

AU - Martens-Lobenhoffer, Jens

AU - Szabo, Csaba

AU - Bode-Böger, Stefanie M.

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N2 - Objectives: We measured and compared serum asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), and L-arginine levels in patients undergoing coronary artery revascularization. Methods: Two groups of patients with coronary artery disease were subjected to coronary artery bypass graft surgery (CABG) with cardiopulmonary bypass (CPB; n=20) or with off-pump CABG surgery (OPCABG; n=21). Blood samples for measurements of ADMA, SDMA, and L-arginine were withdrawn and determined by liquid chromatography-tandem mass spectrometry from the coronary sinus (CS) and from the peripheral vein. Results: On the basis of the intraoperative (CS) samples, ADMA levels rose in the CPB group (F=0.416, P<0.685 and F=14.751, P<0.001 for OPCABG and CPB groups, respectively). A similar significant increase of ADMA was observed in the peripheral blood (F=30.738, P<0.001) during CPB, whereas ADMA levels remained unchanged during OPCABG. The time course of L-arginine levels was significantly different in the blood samples from CS (F=3.255, P<0.05), when compared with samples from the peripheral blood (F=3.255, P<0.05). The values of the L-arginine/ADMA ratio were significantly higher in the OPCABG group at baseline and on the first postoperative day compared with the results of the CPB group (178.29±11.56 vs. 136.28±13.72 and 129.43±7.08 vs. 106.8±6.9 for OPCABG and CPB groups, respectively). Conclusion: Plasma levels of ADMA, SDMA, L-arginine, and L-arginine/ADMA ratio are reliable and feasible markers of an early ischemia-reperfusion injury. During CPB operation, the plasma concentration of ADMA increased significantly and remained elevated until the first postoperative day due to extensive ischemia-reperfusion injury caused by CPB.

AB - Objectives: We measured and compared serum asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), and L-arginine levels in patients undergoing coronary artery revascularization. Methods: Two groups of patients with coronary artery disease were subjected to coronary artery bypass graft surgery (CABG) with cardiopulmonary bypass (CPB; n=20) or with off-pump CABG surgery (OPCABG; n=21). Blood samples for measurements of ADMA, SDMA, and L-arginine were withdrawn and determined by liquid chromatography-tandem mass spectrometry from the coronary sinus (CS) and from the peripheral vein. Results: On the basis of the intraoperative (CS) samples, ADMA levels rose in the CPB group (F=0.416, P<0.685 and F=14.751, P<0.001 for OPCABG and CPB groups, respectively). A similar significant increase of ADMA was observed in the peripheral blood (F=30.738, P<0.001) during CPB, whereas ADMA levels remained unchanged during OPCABG. The time course of L-arginine levels was significantly different in the blood samples from CS (F=3.255, P<0.05), when compared with samples from the peripheral blood (F=3.255, P<0.05). The values of the L-arginine/ADMA ratio were significantly higher in the OPCABG group at baseline and on the first postoperative day compared with the results of the CPB group (178.29±11.56 vs. 136.28±13.72 and 129.43±7.08 vs. 106.8±6.9 for OPCABG and CPB groups, respectively). Conclusion: Plasma levels of ADMA, SDMA, L-arginine, and L-arginine/ADMA ratio are reliable and feasible markers of an early ischemia-reperfusion injury. During CPB operation, the plasma concentration of ADMA increased significantly and remained elevated until the first postoperative day due to extensive ischemia-reperfusion injury caused by CPB.

KW - Asymmetric dimethylarginine

KW - coronary heart disease

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