Effects of cytosine arabinoside on the incorporation of pyrimidine nucleosides into hamster cells transformed by herpes simplex type 1 and type 2 viruses and by human cytomegalovirus

J. Roubal, V. Zavada, J. Vejsada, Istvan Boldogh, V. Vonka

Research output: Contribution to journalArticle

Abstract

The incorporation of 3H-thymidine and 3H-deoxycytidine into acidoprecipitable fraction of hamster cells transformed by herpes simplex viruses type 1 and type 2 and of 3H-thymidine into hamster cells transformed by human cytomegalovirus was found to be resistant to the action of cytosine arabinoside. More 3H-thymidine was incorporated into these cells in the presence than in the absence of the drug. Similar stimulation of 3H-thymidine uptake could be achieved by using unlabelled deoxycytidine instead of cytosine arabinoside. Incorporation of both nucleosides into spontaneously and SV40 transformed cells was efficiently inhibited by the drug.

Original languageEnglish (US)
Pages (from-to)314-318
Number of pages5
JournalActa Virologica
Volume23
Issue number4
StatePublished - 1979
Externally publishedYes

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Pyrimidine Nucleosides
Human Herpesvirus 2
Cytarabine
Human Herpesvirus 1
Cytomegalovirus
Cricetinae
Thymidine
Deoxycytidine
Nucleosides
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Virology
  • Immunology

Cite this

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abstract = "The incorporation of 3H-thymidine and 3H-deoxycytidine into acidoprecipitable fraction of hamster cells transformed by herpes simplex viruses type 1 and type 2 and of 3H-thymidine into hamster cells transformed by human cytomegalovirus was found to be resistant to the action of cytosine arabinoside. More 3H-thymidine was incorporated into these cells in the presence than in the absence of the drug. Similar stimulation of 3H-thymidine uptake could be achieved by using unlabelled deoxycytidine instead of cytosine arabinoside. Incorporation of both nucleosides into spontaneously and SV40 transformed cells was efficiently inhibited by the drug.",
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T1 - Effects of cytosine arabinoside on the incorporation of pyrimidine nucleosides into hamster cells transformed by herpes simplex type 1 and type 2 viruses and by human cytomegalovirus

AU - Roubal, J.

AU - Zavada, V.

AU - Vejsada, J.

AU - Boldogh, Istvan

AU - Vonka, V.

PY - 1979

Y1 - 1979

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