Effects of dietary primrose oil on mammary tumorigenesis induced by 7,12-dimethylbenz(a) anthracene

Soad H. Abou El-Ela, Keith W. Prasse, Richard Carroll, Opal R. Bunce

Research output: Contribution to journalArticle

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Abstract

The mammary tumor-promoting effect of a high-fat diet containing 20% evening primrose oil (PO) was compared to that of a 20% corn oil (CO) diet. Mammary tumors were induced in female Sprague-Dawley rats using 10 mg (Study 1) and 5 mg (Study 2) 7,12-dimethylbenz(a)anthracene (DMBA). The 10 mg dose of DMBA gave a total mammary tumor incidence of 47% in rats fed the PO diet and 80% for those fed the CO diet. When only adenocarcinomas were counted, the malignant mammary tumor incidences were 41% in rats fed the PO diet and 73% in rats fed the CO diet. In a second study using 5 mg DMBA to induce mammary tumors, total tumor incidences were 50% for PO-fed rats and 63% for those receiving a CO diet. Again, when only adenocarcinomas were counted, tumor incidences were 27% for PO- and 63% for CO-dieted rats. Analysis of plasma fatty acid profiles indicated that animals fed a 20% PO diet showed significant increases in 18:3 and 20:4 fatty acids and significant decreases in 16:0 and 18:1 compared to animals fed a 20% CO diet. These results indicate that the mammary tumor promoting effect of a diet containing 20% fat can be diminished by substituting PO for CO. Moreover, the promoting effect on mammary cancer by a high-fat diet could be depressed by feeding a source of γ-linolenic acid (GLA).

Original languageEnglish (US)
Pages (from-to)1041-1044
Number of pages4
JournalLipids
Volume22
Issue number12
DOIs
StatePublished - Dec 1987
Externally publishedYes

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Primula
Primula vulgaris
Unsaturated Dietary Fats
Nutrition
carcinogenesis
Corn Oil
breasts
Oils
Carcinogenesis
Breast
corn oil
mammary neoplasms (animal)
Diet
Tumors
oils
Breast Neoplasms
diet
Rats
rats
incidence

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Food Science

Cite this

Effects of dietary primrose oil on mammary tumorigenesis induced by 7,12-dimethylbenz(a) anthracene. / Abou El-Ela, Soad H.; Prasse, Keith W.; Carroll, Richard; Bunce, Opal R.

In: Lipids, Vol. 22, No. 12, 12.1987, p. 1041-1044.

Research output: Contribution to journalArticle

Abou El-Ela, Soad H. ; Prasse, Keith W. ; Carroll, Richard ; Bunce, Opal R. / Effects of dietary primrose oil on mammary tumorigenesis induced by 7,12-dimethylbenz(a) anthracene. In: Lipids. 1987 ; Vol. 22, No. 12. pp. 1041-1044.
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abstract = "The mammary tumor-promoting effect of a high-fat diet containing 20{\%} evening primrose oil (PO) was compared to that of a 20{\%} corn oil (CO) diet. Mammary tumors were induced in female Sprague-Dawley rats using 10 mg (Study 1) and 5 mg (Study 2) 7,12-dimethylbenz(a)anthracene (DMBA). The 10 mg dose of DMBA gave a total mammary tumor incidence of 47{\%} in rats fed the PO diet and 80{\%} for those fed the CO diet. When only adenocarcinomas were counted, the malignant mammary tumor incidences were 41{\%} in rats fed the PO diet and 73{\%} in rats fed the CO diet. In a second study using 5 mg DMBA to induce mammary tumors, total tumor incidences were 50{\%} for PO-fed rats and 63{\%} for those receiving a CO diet. Again, when only adenocarcinomas were counted, tumor incidences were 27{\%} for PO- and 63{\%} for CO-dieted rats. Analysis of plasma fatty acid profiles indicated that animals fed a 20{\%} PO diet showed significant increases in 18:3 and 20:4 fatty acids and significant decreases in 16:0 and 18:1 compared to animals fed a 20{\%} CO diet. These results indicate that the mammary tumor promoting effect of a diet containing 20{\%} fat can be diminished by substituting PO for CO. Moreover, the promoting effect on mammary cancer by a high-fat diet could be depressed by feeding a source of γ-linolenic acid (GLA).",
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