Effects of Enterectomy on Postoperative Visceral Organ Glucose Exchange

Wiley W. Souba, Patrick Roughneen, Diane L. Goldwater, R. Lawrence Reed, Brian J. Rowlands

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The effects of a 60% small-bowel resection on postoperative visceral organ glucose exchange was studied in order to gain further understanding of the role of the intestinal tract as a supplier of gluconeogenic substrate to the liver following operative stress. We determined the flux of glucose across the gastrointestinal tract, liver, and kidneys in 20 postoperative dogs. With enterectomy portal bloodflow and total hepatic bloodflow were diminished by 33% and 25%, respectively. Arterial glucose was slightly lower in the enterectomized group 6 hr following the operation. Intestinal glucose uptake was diminished by more than 50% in the enterectomized dogs (p <0.01). Net hepatic glucose release fell from 22 μmole/kg/ min to 8 μmole/kg/min (p <0.01). In control animals the kidney was an organ of slight glucose uptake while in the enterectomized group, the kidney released glucose at the rate of 4.1 μmole/kg/min (p <0.05). The data suggest that the gut is an important supplier of gluconeogenic precursors to the liver which are used to support gluconeogenesis in the postoperative period. The ability of the kidney to accelerate glucose production in this setting suggests that metabolic adaptation and cooperation between organs occurs during organ absence or dysfunction which helps preserve glucose homeostasis.

Original languageEnglish (US)
Pages (from-to)128-131
Number of pages4
JournalJournal of Parenteral and Enteral Nutrition
Volume13
Issue number2
DOIs
StatePublished - 1989
Externally publishedYes

Fingerprint

Glucose
glucose
liver
kidneys
Liver
Kidney
Dogs
uptake mechanisms
Gluconeogenesis
gluconeogenesis
dogs
resection
Postoperative Period
gastrointestinal system
preserves
Gastrointestinal Tract
homeostasis
intestines
Homeostasis
digestive system

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Food Science

Cite this

Effects of Enterectomy on Postoperative Visceral Organ Glucose Exchange. / Souba, Wiley W.; Roughneen, Patrick; Goldwater, Diane L.; Reed, R. Lawrence; Rowlands, Brian J.

In: Journal of Parenteral and Enteral Nutrition, Vol. 13, No. 2, 1989, p. 128-131.

Research output: Contribution to journalArticle

Souba, Wiley W. ; Roughneen, Patrick ; Goldwater, Diane L. ; Reed, R. Lawrence ; Rowlands, Brian J. / Effects of Enterectomy on Postoperative Visceral Organ Glucose Exchange. In: Journal of Parenteral and Enteral Nutrition. 1989 ; Vol. 13, No. 2. pp. 128-131.
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