Effects of Exogenous Growth Hormone on Resting Pulmonary Function in Children with Thermal Injury

Oscar Suman, Ronald P. Mlcak, David Herndon

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Burned children living beyond the acute phase of injury often have extensive physical functional limitations, such as impaired spirometry pulmonary function (PF). In patients with both lung disease and nutritional compromise, such as cystic fibrosis, studies suggest that growth hormone (GH) therapy improves PF. However, whether GH will improve PF in burned children is presently unknown. We therefore evaluated whether GH administration of 0.05 mg/kg/day for 1 year would improve PF in burned children. Thirty children, aged 7 to 18, with a 40% or more total body surface area burned were randomized into two groups and studied. One group received GH (n = 17) and the other received saline (n = 13). No differences were noted at hospital discharge between groups in age, % total body surface area, height, and weight. At 12 months after burn, both groups had similar height and weight. Baseline PF were below normal in both groups, but no statistical differences were noted between groups. At 1 year, there was a significant increase in PF in both groups; however, this increase in PF was similar in both groups. We conclude that the response in PF in burned children from the administration of GH prescribed for up to 1 year is limited.

Original languageEnglish (US)
Pages (from-to)287-293
Number of pages7
JournalJournal of Burn Care and Rehabilitation
Volume25
Issue number3
StatePublished - May 2004

Fingerprint

Growth Hormone
Hot Temperature
Lung
Wounds and Injuries
Body Surface Area
Weights and Measures
Spirometry
Cystic Fibrosis
Lung Diseases
Age Groups

ASJC Scopus subject areas

  • Rehabilitation
  • Surgery
  • Nursing(all)
  • Health Professions(all)
  • Emergency Medicine

Cite this

Effects of Exogenous Growth Hormone on Resting Pulmonary Function in Children with Thermal Injury. / Suman, Oscar; Mlcak, Ronald P.; Herndon, David.

In: Journal of Burn Care and Rehabilitation, Vol. 25, No. 3, 05.2004, p. 287-293.

Research output: Contribution to journalArticle

@article{c58dc0ffa9cb4d0daa1cab1cfa8a0563,
title = "Effects of Exogenous Growth Hormone on Resting Pulmonary Function in Children with Thermal Injury",
abstract = "Burned children living beyond the acute phase of injury often have extensive physical functional limitations, such as impaired spirometry pulmonary function (PF). In patients with both lung disease and nutritional compromise, such as cystic fibrosis, studies suggest that growth hormone (GH) therapy improves PF. However, whether GH will improve PF in burned children is presently unknown. We therefore evaluated whether GH administration of 0.05 mg/kg/day for 1 year would improve PF in burned children. Thirty children, aged 7 to 18, with a 40{\%} or more total body surface area burned were randomized into two groups and studied. One group received GH (n = 17) and the other received saline (n = 13). No differences were noted at hospital discharge between groups in age, {\%} total body surface area, height, and weight. At 12 months after burn, both groups had similar height and weight. Baseline PF were below normal in both groups, but no statistical differences were noted between groups. At 1 year, there was a significant increase in PF in both groups; however, this increase in PF was similar in both groups. We conclude that the response in PF in burned children from the administration of GH prescribed for up to 1 year is limited.",
author = "Oscar Suman and Mlcak, {Ronald P.} and David Herndon",
year = "2004",
month = "5",
language = "English (US)",
volume = "25",
pages = "287--293",
journal = "Journal of Burn Care and Research",
issn = "1559-047X",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Effects of Exogenous Growth Hormone on Resting Pulmonary Function in Children with Thermal Injury

AU - Suman, Oscar

AU - Mlcak, Ronald P.

AU - Herndon, David

PY - 2004/5

Y1 - 2004/5

N2 - Burned children living beyond the acute phase of injury often have extensive physical functional limitations, such as impaired spirometry pulmonary function (PF). In patients with both lung disease and nutritional compromise, such as cystic fibrosis, studies suggest that growth hormone (GH) therapy improves PF. However, whether GH will improve PF in burned children is presently unknown. We therefore evaluated whether GH administration of 0.05 mg/kg/day for 1 year would improve PF in burned children. Thirty children, aged 7 to 18, with a 40% or more total body surface area burned were randomized into two groups and studied. One group received GH (n = 17) and the other received saline (n = 13). No differences were noted at hospital discharge between groups in age, % total body surface area, height, and weight. At 12 months after burn, both groups had similar height and weight. Baseline PF were below normal in both groups, but no statistical differences were noted between groups. At 1 year, there was a significant increase in PF in both groups; however, this increase in PF was similar in both groups. We conclude that the response in PF in burned children from the administration of GH prescribed for up to 1 year is limited.

AB - Burned children living beyond the acute phase of injury often have extensive physical functional limitations, such as impaired spirometry pulmonary function (PF). In patients with both lung disease and nutritional compromise, such as cystic fibrosis, studies suggest that growth hormone (GH) therapy improves PF. However, whether GH will improve PF in burned children is presently unknown. We therefore evaluated whether GH administration of 0.05 mg/kg/day for 1 year would improve PF in burned children. Thirty children, aged 7 to 18, with a 40% or more total body surface area burned were randomized into two groups and studied. One group received GH (n = 17) and the other received saline (n = 13). No differences were noted at hospital discharge between groups in age, % total body surface area, height, and weight. At 12 months after burn, both groups had similar height and weight. Baseline PF were below normal in both groups, but no statistical differences were noted between groups. At 1 year, there was a significant increase in PF in both groups; however, this increase in PF was similar in both groups. We conclude that the response in PF in burned children from the administration of GH prescribed for up to 1 year is limited.

UR - http://www.scopus.com/inward/record.url?scp=2442501627&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2442501627&partnerID=8YFLogxK

M3 - Article

C2 - 15273470

AN - SCOPUS:2442501627

VL - 25

SP - 287

EP - 293

JO - Journal of Burn Care and Research

JF - Journal of Burn Care and Research

SN - 1559-047X

IS - 3

ER -