Effects of flagellin on the functions of follicle-associated epithelium

Sophie M. Chabot; May Shawi; Tonyia Eaves-Pyles; Marian R. Neutra

doi:10.1086/591056

Effects of flagellin on the functions of follicle-associated epithelium

Sophie M. Chabot, May Shawi, Tonyia Eaves-Pyles, Marian R. Neutra

Microbiology And Immunology

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Bacterial flagellin activates innate immune responses by signaling through Toll-like receptor 5 and is a potential vaccine adjuvant. Mucosal lymphoid follicles, inductive sites for adaptive mucosal immune responses, are covered by a follicle-associated epithelium (FAE) specialized for the uptake of antigens. This study demonstrates that mucosal application of Salmonella dublin flagellin enhanced transepithelial transport of microparticles by the FAE of mouse Peyer's patches in vivo. Flagellin also induced rapid, matrix metalloproteinase- dependent migration of subepithelial dendritic cells (DCs) into the FAE, better positioning DCs for antigen capture. These innate responses to flagellin enhance FAE functions and may promote adaptive immune responses in the mucosa.

Original language	English (US)
Pages (from-to)	907-910
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	198
Issue number	6
DOIs	https://doi.org/10.1086/591056
State	Published - Sep 15 2008

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

Access to Document

10.1086/591056

Cite this

@article{7ab5eb7def3a41fdaa1189a8c23ad3bd,

title = "Effects of flagellin on the functions of follicle-associated epithelium",

abstract = "Bacterial flagellin activates innate immune responses by signaling through Toll-like receptor 5 and is a potential vaccine adjuvant. Mucosal lymphoid follicles, inductive sites for adaptive mucosal immune responses, are covered by a follicle-associated epithelium (FAE) specialized for the uptake of antigens. This study demonstrates that mucosal application of Salmonella dublin flagellin enhanced transepithelial transport of microparticles by the FAE of mouse Peyer's patches in vivo. Flagellin also induced rapid, matrix metalloproteinase- dependent migration of subepithelial dendritic cells (DCs) into the FAE, better positioning DCs for antigen capture. These innate responses to flagellin enhance FAE functions and may promote adaptive immune responses in the mucosa.",

author = "Chabot, {Sophie M.} and May Shawi and Tonyia Eaves-Pyles and Neutra, {Marian R.}",

note = "Funding Information: Received 10 August 2007; accepted 6 November 2007; electronically published 22 August 2008. Potential conflicts of interest: none reported. Financial support: Canadian Institute of Health Research (postdoctoral fellowship to S.M.C.); National Institutes of Health (grant HD17557 to M.R.N.; grant DK34854 to the Harvard Digestive Diseases Center). Reprints or correspondence: Dr. Marian R. Neutra, Children{\textquoteright}s Hospital, GI Cell Biology Laboratory, Enders 720, 300 Longwood Ave., Boston, MA 02115 (marian.neutra@childrens.harvard.edu).",

year = "2008",

month = sep,

day = "15",

doi = "10.1086/591056",

language = "English (US)",

volume = "198",

pages = "907--910",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "6",

}

TY - JOUR

T1 - Effects of flagellin on the functions of follicle-associated epithelium

AU - Chabot, Sophie M.

AU - Shawi, May

AU - Eaves-Pyles, Tonyia

AU - Neutra, Marian R.

N1 - Funding Information: Received 10 August 2007; accepted 6 November 2007; electronically published 22 August 2008. Potential conflicts of interest: none reported. Financial support: Canadian Institute of Health Research (postdoctoral fellowship to S.M.C.); National Institutes of Health (grant HD17557 to M.R.N.; grant DK34854 to the Harvard Digestive Diseases Center). Reprints or correspondence: Dr. Marian R. Neutra, Children’s Hospital, GI Cell Biology Laboratory, Enders 720, 300 Longwood Ave., Boston, MA 02115 (marian.neutra@childrens.harvard.edu).

PY - 2008/9/15

Y1 - 2008/9/15

N2 - Bacterial flagellin activates innate immune responses by signaling through Toll-like receptor 5 and is a potential vaccine adjuvant. Mucosal lymphoid follicles, inductive sites for adaptive mucosal immune responses, are covered by a follicle-associated epithelium (FAE) specialized for the uptake of antigens. This study demonstrates that mucosal application of Salmonella dublin flagellin enhanced transepithelial transport of microparticles by the FAE of mouse Peyer's patches in vivo. Flagellin also induced rapid, matrix metalloproteinase- dependent migration of subepithelial dendritic cells (DCs) into the FAE, better positioning DCs for antigen capture. These innate responses to flagellin enhance FAE functions and may promote adaptive immune responses in the mucosa.

AB - Bacterial flagellin activates innate immune responses by signaling through Toll-like receptor 5 and is a potential vaccine adjuvant. Mucosal lymphoid follicles, inductive sites for adaptive mucosal immune responses, are covered by a follicle-associated epithelium (FAE) specialized for the uptake of antigens. This study demonstrates that mucosal application of Salmonella dublin flagellin enhanced transepithelial transport of microparticles by the FAE of mouse Peyer's patches in vivo. Flagellin also induced rapid, matrix metalloproteinase- dependent migration of subepithelial dendritic cells (DCs) into the FAE, better positioning DCs for antigen capture. These innate responses to flagellin enhance FAE functions and may promote adaptive immune responses in the mucosa.

UR - http://www.scopus.com/inward/record.url?scp=51749111427&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=51749111427&partnerID=8YFLogxK

U2 - 10.1086/591056

DO - 10.1086/591056

M3 - Article

C2 - 18721059

AN - SCOPUS:51749111427

SN - 0022-1899

VL - 198

SP - 907

EP - 910

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 6

ER -

Effects of flagellin on the functions of follicle-associated epithelium

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this