Effects of flagellin on the functions of follicle-associated epithelium

Sophie M. Chabot, May Shawi, Tonyia Eaves-Pyles, Marian R. Neutra

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Bacterial flagellin activates innate immune responses by signaling through Toll-like receptor 5 and is a potential vaccine adjuvant. Mucosal lymphoid follicles, inductive sites for adaptive mucosal immune responses, are covered by a follicle-associated epithelium (FAE) specialized for the uptake of antigens. This study demonstrates that mucosal application of Salmonella dublin flagellin enhanced transepithelial transport of microparticles by the FAE of mouse Peyer's patches in vivo. Flagellin also induced rapid, matrix metalloproteinase- dependent migration of subepithelial dendritic cells (DCs) into the FAE, better positioning DCs for antigen capture. These innate responses to flagellin enhance FAE functions and may promote adaptive immune responses in the mucosa.

Original languageEnglish (US)
Pages (from-to)907-910
Number of pages4
JournalJournal of Infectious Diseases
Volume198
Issue number6
DOIs
StatePublished - Sep 15 2008

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Flagellin
Epithelium
Adaptive Immunity
Dendritic Cells
Toll-Like Receptor 5
Antigens
Peyer's Patches
Mucosal Immunity
Matrix Metalloproteinases
Innate Immunity
Salmonella
Mucous Membrane
Vaccines

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Effects of flagellin on the functions of follicle-associated epithelium. / Chabot, Sophie M.; Shawi, May; Eaves-Pyles, Tonyia; Neutra, Marian R.

In: Journal of Infectious Diseases, Vol. 198, No. 6, 15.09.2008, p. 907-910.

Research output: Contribution to journalArticle

Chabot, Sophie M. ; Shawi, May ; Eaves-Pyles, Tonyia ; Neutra, Marian R. / Effects of flagellin on the functions of follicle-associated epithelium. In: Journal of Infectious Diseases. 2008 ; Vol. 198, No. 6. pp. 907-910.
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