Effects of folic acid and vitamin B complex on serum C-reactive protein and albumin levels in stable hemodialysis patients

Tzu Yuan Chang, Kang Ju Chou, Chin Feng Tseng, Hsiao Min Chung, Hua Chang Fang, Yao Min Hung, Ming Jei Wu, Huey-Ming Tzeng, Chang Chung Lind, Kuo Cheng Lu

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective: Folic acid and vitamin B complex administration in uremic patients has been reported to lower plasma total homocysteine (tHcy) levels, but whether or not this has a beneficial effect on the inflammatory state is not clear. Methods: We conducted a randomized open labeled study to determine the effects of folic acid (5 mg daily) and vitamin B complex administration on plasma tHcy levels as well as inflammatory (serum high-sensitivity C reactive protein, hs-CRP) and nutritional (serum albumin) markers in patients on maintenance hemodialysis. Treatment was given for 3 consecutive months to 61 patients on maintenance hemodialysis. Another 60 patients, all age-, sex-, hemodialysis duration-matched served as control group. Main outcome measures: Plasma tHcy, serum hs-CRP, albumin, creatinine (Cr), post-dialysis body weight (BW), and normalized protein catabolism rate (nPCR). Results: After 3 months, levels of plasma tHcy and serum hs-CRP, Cr, and nPCR were significantly decreased while levels of serum albumin, vitamin B12, folate, and BW were significantly increased. The dialytic dose (KT/V) and dietary intake remained unchanged. However, correlations between the magnitude of reduction of tHcy & hs-CRP, tHcy & Cr, and Cr & nPCR were statistically significant. Conclusions: Folic acid and vitamin B complex co-administration effectively lowers tHcy and hs-CRP levels and increases albumin levels in stable hemodialysis subjects, underscoring their potential benefit to attenuate the state of inflammation and possibly improve the nutritional status in patients on hemodialysis.

Original languageEnglish (US)
Pages (from-to)1879-1886
Number of pages8
JournalCurrent Medical Research and Opinion
Volume23
Issue number8
DOIs
StatePublished - Aug 1 2007
Externally publishedYes

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Vitamin B Complex
Homocysteine
Folic Acid
C-Reactive Protein
Renal Dialysis
Blood Proteins
Albumins
Creatinine
Serum Albumin
Serum
Body Weight
Maintenance
Proteins
Vitamin B 12
Nutritional Status
Dialysis
Biomarkers
Outcome Assessment (Health Care)
Inflammation
Control Groups

Keywords

  • Albumin
  • C-reactive protein
  • Folic acid
  • Hemodialysis
  • Homocysteine
  • Vitamin B

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Effects of folic acid and vitamin B complex on serum C-reactive protein and albumin levels in stable hemodialysis patients. / Chang, Tzu Yuan; Chou, Kang Ju; Tseng, Chin Feng; Chung, Hsiao Min; Fang, Hua Chang; Hung, Yao Min; Wu, Ming Jei; Tzeng, Huey-Ming; Lind, Chang Chung; Lu, Kuo Cheng.

In: Current Medical Research and Opinion, Vol. 23, No. 8, 01.08.2007, p. 1879-1886.

Research output: Contribution to journalArticle

Chang, Tzu Yuan ; Chou, Kang Ju ; Tseng, Chin Feng ; Chung, Hsiao Min ; Fang, Hua Chang ; Hung, Yao Min ; Wu, Ming Jei ; Tzeng, Huey-Ming ; Lind, Chang Chung ; Lu, Kuo Cheng. / Effects of folic acid and vitamin B complex on serum C-reactive protein and albumin levels in stable hemodialysis patients. In: Current Medical Research and Opinion. 2007 ; Vol. 23, No. 8. pp. 1879-1886.
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TY - JOUR

T1 - Effects of folic acid and vitamin B complex on serum C-reactive protein and albumin levels in stable hemodialysis patients

AU - Chang, Tzu Yuan

AU - Chou, Kang Ju

AU - Tseng, Chin Feng

AU - Chung, Hsiao Min

AU - Fang, Hua Chang

AU - Hung, Yao Min

AU - Wu, Ming Jei

AU - Tzeng, Huey-Ming

AU - Lind, Chang Chung

AU - Lu, Kuo Cheng

PY - 2007/8/1

Y1 - 2007/8/1

N2 - Objective: Folic acid and vitamin B complex administration in uremic patients has been reported to lower plasma total homocysteine (tHcy) levels, but whether or not this has a beneficial effect on the inflammatory state is not clear. Methods: We conducted a randomized open labeled study to determine the effects of folic acid (5 mg daily) and vitamin B complex administration on plasma tHcy levels as well as inflammatory (serum high-sensitivity C reactive protein, hs-CRP) and nutritional (serum albumin) markers in patients on maintenance hemodialysis. Treatment was given for 3 consecutive months to 61 patients on maintenance hemodialysis. Another 60 patients, all age-, sex-, hemodialysis duration-matched served as control group. Main outcome measures: Plasma tHcy, serum hs-CRP, albumin, creatinine (Cr), post-dialysis body weight (BW), and normalized protein catabolism rate (nPCR). Results: After 3 months, levels of plasma tHcy and serum hs-CRP, Cr, and nPCR were significantly decreased while levels of serum albumin, vitamin B12, folate, and BW were significantly increased. The dialytic dose (KT/V) and dietary intake remained unchanged. However, correlations between the magnitude of reduction of tHcy & hs-CRP, tHcy & Cr, and Cr & nPCR were statistically significant. Conclusions: Folic acid and vitamin B complex co-administration effectively lowers tHcy and hs-CRP levels and increases albumin levels in stable hemodialysis subjects, underscoring their potential benefit to attenuate the state of inflammation and possibly improve the nutritional status in patients on hemodialysis.

AB - Objective: Folic acid and vitamin B complex administration in uremic patients has been reported to lower plasma total homocysteine (tHcy) levels, but whether or not this has a beneficial effect on the inflammatory state is not clear. Methods: We conducted a randomized open labeled study to determine the effects of folic acid (5 mg daily) and vitamin B complex administration on plasma tHcy levels as well as inflammatory (serum high-sensitivity C reactive protein, hs-CRP) and nutritional (serum albumin) markers in patients on maintenance hemodialysis. Treatment was given for 3 consecutive months to 61 patients on maintenance hemodialysis. Another 60 patients, all age-, sex-, hemodialysis duration-matched served as control group. Main outcome measures: Plasma tHcy, serum hs-CRP, albumin, creatinine (Cr), post-dialysis body weight (BW), and normalized protein catabolism rate (nPCR). Results: After 3 months, levels of plasma tHcy and serum hs-CRP, Cr, and nPCR were significantly decreased while levels of serum albumin, vitamin B12, folate, and BW were significantly increased. The dialytic dose (KT/V) and dietary intake remained unchanged. However, correlations between the magnitude of reduction of tHcy & hs-CRP, tHcy & Cr, and Cr & nPCR were statistically significant. Conclusions: Folic acid and vitamin B complex co-administration effectively lowers tHcy and hs-CRP levels and increases albumin levels in stable hemodialysis subjects, underscoring their potential benefit to attenuate the state of inflammation and possibly improve the nutritional status in patients on hemodialysis.

KW - Albumin

KW - C-reactive protein

KW - Folic acid

KW - Hemodialysis

KW - Homocysteine

KW - Vitamin B

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U2 - 10.1185/030079907X218077

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SP - 1879

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JO - Current Medical Research and Opinion

JF - Current Medical Research and Opinion

SN - 0300-7995

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ER -