Effects of ibuprofen on airway vascular response to cotton smoke injury

Salahadin Abdi, Lillian D. Traber, David Herndon, Christian S. Rogers, Daniel L. Traber

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We studied the effects of ibuprofen on bronchial blood flow and myocordial function after inhalation injury. Sheep (n = 12) were chronically instrumented with cardiovascular and pulmonary catheters. After 5 days of recovery period, baseline data were collected and the sheep were divided into two groups. Group S (n = 6) were insufflated with 48 breaths of cotton smoke; while group I (n = 6) were pretreated with ibuprofen (12 mg/kg bolus followed by 3 mg/kg/h continuous infusion for 24 h) and challenged with the same dose of smoke. All the animals were studied for 24 h. Bronchial blood flow increased significantly in both groups throughout the experimental period; while stroke volume as well as right and left ventricular stroke work indices of both groups were significantly decreased (group I worse than group S) in the second half of the experimental period. These data suggest that vasodilatory prostaglandins do not play a major role in the bronchial vascular response to smoke inhalation injury and myocardial depression seen post injury is worse in animals treated with ibuprofen.

Original languageEnglish (US)
Pages (from-to)475-481
Number of pages7
JournalEuropean Journal of Pharmacology: Environmental Toxicology and
Volume293
Issue number4
DOIs
StatePublished - Dec 7 1995

Fingerprint

Ibuprofen
Smoke
Cotton
Blood Vessels
Sheep
Wounds and Injuries
Animals
Smoke Inhalation Injury
Blood
Catheters
Stroke Volume
Inhalation
Prostaglandins
Stroke
Recovery
Lung

Keywords

  • Bronchial blood flow
  • Cyclooxygenase inhibitor
  • Hemodynamics
  • Ibuprofen
  • smoke inhalation injury

ASJC Scopus subject areas

  • Pollution
  • Pharmacology
  • Toxicology

Cite this

Effects of ibuprofen on airway vascular response to cotton smoke injury. / Abdi, Salahadin; Traber, Lillian D.; Herndon, David; Rogers, Christian S.; Traber, Daniel L.

In: European Journal of Pharmacology: Environmental Toxicology and, Vol. 293, No. 4, 07.12.1995, p. 475-481.

Research output: Contribution to journalArticle

Abdi, Salahadin ; Traber, Lillian D. ; Herndon, David ; Rogers, Christian S. ; Traber, Daniel L. / Effects of ibuprofen on airway vascular response to cotton smoke injury. In: European Journal of Pharmacology: Environmental Toxicology and. 1995 ; Vol. 293, No. 4. pp. 475-481.
@article{cc2bf21c4412477c882823ef341b2c58,
title = "Effects of ibuprofen on airway vascular response to cotton smoke injury",
abstract = "We studied the effects of ibuprofen on bronchial blood flow and myocordial function after inhalation injury. Sheep (n = 12) were chronically instrumented with cardiovascular and pulmonary catheters. After 5 days of recovery period, baseline data were collected and the sheep were divided into two groups. Group S (n = 6) were insufflated with 48 breaths of cotton smoke; while group I (n = 6) were pretreated with ibuprofen (12 mg/kg bolus followed by 3 mg/kg/h continuous infusion for 24 h) and challenged with the same dose of smoke. All the animals were studied for 24 h. Bronchial blood flow increased significantly in both groups throughout the experimental period; while stroke volume as well as right and left ventricular stroke work indices of both groups were significantly decreased (group I worse than group S) in the second half of the experimental period. These data suggest that vasodilatory prostaglandins do not play a major role in the bronchial vascular response to smoke inhalation injury and myocardial depression seen post injury is worse in animals treated with ibuprofen.",
keywords = "Bronchial blood flow, Cyclooxygenase inhibitor, Hemodynamics, Ibuprofen, smoke inhalation injury",
author = "Salahadin Abdi and Traber, {Lillian D.} and David Herndon and Rogers, {Christian S.} and Traber, {Daniel L.}",
year = "1995",
month = "12",
day = "7",
doi = "10.1016/0926-6917(95)90068-3",
language = "English (US)",
volume = "293",
pages = "475--481",
journal = "Environmental Toxicology and Pharmacology",
issn = "1382-6689",
publisher = "Elsevier",
number = "4",

}

TY - JOUR

T1 - Effects of ibuprofen on airway vascular response to cotton smoke injury

AU - Abdi, Salahadin

AU - Traber, Lillian D.

AU - Herndon, David

AU - Rogers, Christian S.

AU - Traber, Daniel L.

PY - 1995/12/7

Y1 - 1995/12/7

N2 - We studied the effects of ibuprofen on bronchial blood flow and myocordial function after inhalation injury. Sheep (n = 12) were chronically instrumented with cardiovascular and pulmonary catheters. After 5 days of recovery period, baseline data were collected and the sheep were divided into two groups. Group S (n = 6) were insufflated with 48 breaths of cotton smoke; while group I (n = 6) were pretreated with ibuprofen (12 mg/kg bolus followed by 3 mg/kg/h continuous infusion for 24 h) and challenged with the same dose of smoke. All the animals were studied for 24 h. Bronchial blood flow increased significantly in both groups throughout the experimental period; while stroke volume as well as right and left ventricular stroke work indices of both groups were significantly decreased (group I worse than group S) in the second half of the experimental period. These data suggest that vasodilatory prostaglandins do not play a major role in the bronchial vascular response to smoke inhalation injury and myocardial depression seen post injury is worse in animals treated with ibuprofen.

AB - We studied the effects of ibuprofen on bronchial blood flow and myocordial function after inhalation injury. Sheep (n = 12) were chronically instrumented with cardiovascular and pulmonary catheters. After 5 days of recovery period, baseline data were collected and the sheep were divided into two groups. Group S (n = 6) were insufflated with 48 breaths of cotton smoke; while group I (n = 6) were pretreated with ibuprofen (12 mg/kg bolus followed by 3 mg/kg/h continuous infusion for 24 h) and challenged with the same dose of smoke. All the animals were studied for 24 h. Bronchial blood flow increased significantly in both groups throughout the experimental period; while stroke volume as well as right and left ventricular stroke work indices of both groups were significantly decreased (group I worse than group S) in the second half of the experimental period. These data suggest that vasodilatory prostaglandins do not play a major role in the bronchial vascular response to smoke inhalation injury and myocardial depression seen post injury is worse in animals treated with ibuprofen.

KW - Bronchial blood flow

KW - Cyclooxygenase inhibitor

KW - Hemodynamics

KW - Ibuprofen

KW - smoke inhalation injury

UR - http://www.scopus.com/inward/record.url?scp=0028970864&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028970864&partnerID=8YFLogxK

U2 - 10.1016/0926-6917(95)90068-3

DO - 10.1016/0926-6917(95)90068-3

M3 - Article

VL - 293

SP - 475

EP - 481

JO - Environmental Toxicology and Pharmacology

JF - Environmental Toxicology and Pharmacology

SN - 1382-6689

IS - 4

ER -