Effects of inhalation injury on airway blood flow and edema formation

George Kramer, David Herndon, H. A. Linares, D. L. Traber

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

We measured airway blood flow in unanesthetized sheep under control conditions and after lung injury induced by inhalation of cotton smoke. Blood flows in trachea, carina, main stem bronchi, intraparenchymal bronchi, and whole lung were measured by injection of radioactive microspheres. In 10 control sheep mean blood flow (± SD) was trachea, 17.2 ± 10.5; main stem bronchi, 17.5 ± 7.6; and whole lung (parenchyma inclusive of all small intraparenchymal airways), 20.5 ± 11.9 ml · min-1/100 gm tissue weight. After injury, measurements were made 8 to 30 hours after smoke inhalation when respiratory distress was evident by arterial oxygen tensions of less than 60 mm Hg. Inhalation injury had little effect on cardiac output or blood flow to peripheral tissue. However, after inhalation injury airway blood flow (n = 6) was increased nine times in trachea, eight times in main stem bronchi, twelve times in intraparenchymal bronchi, and two times in whole lung. The increased airway blood flow resulted from a selective vasodilation of the airway vasculature because arterial driving pressures were unchanged by inhalation injury. Other investigators have shown that the microvascular permeability of the bronchial circulation is remarkably sensitive to inflammation, and the present experiments suggest that a selective vasodilation of the airway vasculature is another aspect of the airway response to inflammation. Increased airway blood flow through a leaky microvascularture may increase capillary filtrate from the bronchial circulation and contribute to the pulmonary edema of inhalation injury.

Original languageEnglish (US)
Pages (from-to)45-51
Number of pages7
JournalJournal of Burn Care and Rehabilitation
Volume10
Issue number1
StatePublished - 1989

Fingerprint

Inhalation
Edema
Bronchi
Wounds and Injuries
Trachea
Vasodilation
Smoke
Lung
Sheep
Arterial Pressure
Inflammation
Capillary Permeability
Lung Injury
Pulmonary Edema
Microspheres
Cardiac Output
Research Personnel
Oxygen
Weights and Measures
Injections

ASJC Scopus subject areas

  • Emergency Medicine
  • Rehabilitation
  • Surgery
  • Nursing(all)
  • Health Professions(all)

Cite this

Effects of inhalation injury on airway blood flow and edema formation. / Kramer, George; Herndon, David; Linares, H. A.; Traber, D. L.

In: Journal of Burn Care and Rehabilitation, Vol. 10, No. 1, 1989, p. 45-51.

Research output: Contribution to journalArticle

Kramer, George ; Herndon, David ; Linares, H. A. ; Traber, D. L. / Effects of inhalation injury on airway blood flow and edema formation. In: Journal of Burn Care and Rehabilitation. 1989 ; Vol. 10, No. 1. pp. 45-51.
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