Effects of insulin on wound healing

Edgar J. Pierre, Robert E. Barrow, Hal K. Hawkins, Thuan T. Nguyen, Yoichi Sakurai, Manu Desai, Robert R. Wolfe, David Herndon

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

Background: Insulin plus glucose, given for 7 days to hyper- metabolic burn patients, has been shown to stimulate limb protein anabolism. We hypothesized that insulin plus glucose given to burn patients would also stimulate wound healing. Methods: Six patients with burns >40% total body surface area were randomized to receive insulin or placebo in a crossover study during the healing of their first and second donor sites. Insulin treatment was titrated at 25 to 49 U/h to achieve a plasma insulin level of 400 to 900 μU/mL for 7 days. Patients receiving insulin received dextrose 50 at 20 to 50 mL/h, titrated to maintain euglycemia. Donor-site biopsies were taken at 7 days and evaluated by three observers blinded to the treatment. Results: The mean (±SD) donor-site healing time was reduced from 6.5 ± 1.0 days with placebo to 4.7 ± 1.2 days during insulin infusion (p < 0.05). Laminin showed intense staining along the basal lamina and blood vessels. Collagen type IV staining also increased after insulin therapy compared with placebo. Conclusion: Data indicate that high doses of insulin and glucose can be safely administered to massively burned patients to improve wound matrix formation.

Original languageEnglish (US)
Pages (from-to)342-345
Number of pages4
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume44
Issue number2
DOIs
StatePublished - Feb 1998
Externally publishedYes

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Wound Healing
Insulin
Glucose
Placebos
Tissue Donors
Staining and Labeling
Collagen Type IV
Body Surface Area
Laminin
Burns
Basement Membrane
Cross-Over Studies
Blood Vessels
Therapeutics
Extremities
Biopsy
Wounds and Injuries

ASJC Scopus subject areas

  • Surgery

Cite this

Pierre, E. J., Barrow, R. E., Hawkins, H. K., Nguyen, T. T., Sakurai, Y., Desai, M., ... Herndon, D. (1998). Effects of insulin on wound healing. Journal of Trauma - Injury, Infection and Critical Care, 44(2), 342-345. https://doi.org/10.1097/00005373-199802000-00019

Effects of insulin on wound healing. / Pierre, Edgar J.; Barrow, Robert E.; Hawkins, Hal K.; Nguyen, Thuan T.; Sakurai, Yoichi; Desai, Manu; Wolfe, Robert R.; Herndon, David.

In: Journal of Trauma - Injury, Infection and Critical Care, Vol. 44, No. 2, 02.1998, p. 342-345.

Research output: Contribution to journalArticle

Pierre, EJ, Barrow, RE, Hawkins, HK, Nguyen, TT, Sakurai, Y, Desai, M, Wolfe, RR & Herndon, D 1998, 'Effects of insulin on wound healing', Journal of Trauma - Injury, Infection and Critical Care, vol. 44, no. 2, pp. 342-345. https://doi.org/10.1097/00005373-199802000-00019
Pierre EJ, Barrow RE, Hawkins HK, Nguyen TT, Sakurai Y, Desai M et al. Effects of insulin on wound healing. Journal of Trauma - Injury, Infection and Critical Care. 1998 Feb;44(2):342-345. https://doi.org/10.1097/00005373-199802000-00019
Pierre, Edgar J. ; Barrow, Robert E. ; Hawkins, Hal K. ; Nguyen, Thuan T. ; Sakurai, Yoichi ; Desai, Manu ; Wolfe, Robert R. ; Herndon, David. / Effects of insulin on wound healing. In: Journal of Trauma - Injury, Infection and Critical Care. 1998 ; Vol. 44, No. 2. pp. 342-345.
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