Effects of interleukin-4 on antigen-specific antibody synthesis by lymphocytes from old and young adults

E. A. Burns, G. D. L'Hommedieu, J. L. Cunning, James Goodwin

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The current series of experiments were designed to explore the role of the B cell growth factor, interleukin-4 (IL-4), in the age-related decrease in production of antitetanus toxoid antibody in vitro. Exogenous recombinant IL- 4 led to significant suppression of antitetanus toxoid antibody synthesis and numbers of antitetanus toxoid antibody-secreting B cells in cultures from healthy old subjects and healthy young subjects. These effects were most pronounced when IL-4 was present during the early phase of culture. Lymphocytes from old subjects were less sensitive to these effects and produced significantly less IL-4 than did lymphocytes from young controls. The addition of exogenous IL-4 may be inhibiting early activation signals that normally stimulate proliferation of B cells. A decreased sensitivity to the growth-promoting effects of IL-4 may be one of the mechanisms underlying defective specific antibody synthesis in aging.

Original languageEnglish (US)
Pages (from-to)227-231
Number of pages5
JournalLymphokine and Cytokine Research
Volume13
Issue number4
StatePublished - 1994
Externally publishedYes

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Interleukin-4
Young Adult
Lymphocytes
Toxoids
Antigens
Antibodies
B-Lymphocytes
Healthy Volunteers
Antibody-Producing Cells
Intercellular Signaling Peptides and Proteins
Cell Culture Techniques
Growth

ASJC Scopus subject areas

  • Immunology
  • Hematology

Cite this

Effects of interleukin-4 on antigen-specific antibody synthesis by lymphocytes from old and young adults. / Burns, E. A.; L'Hommedieu, G. D.; Cunning, J. L.; Goodwin, James.

In: Lymphokine and Cytokine Research, Vol. 13, No. 4, 1994, p. 227-231.

Research output: Contribution to journalArticle

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