Effects of intestinal transplantation on postprandial motility and regulation of intestinal transit

C. P. Johnson, S. K. Sarna, Y. R. Zhu, E. Buchmann, L. Bonham, G. L. Telford, A. M. Roza, M. B. Adams

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background. The effects of intestinal transplantation on gut motility have not been completely defined. In this study we examine the effects of ileal transplantation on ileal smooth muscle contractility, together with gastroduodenal emptying, intestinal flow, and transit rates in a canine model of short-gut syndrome. Methods. Animals (n = 22) were instrumented with strain gauge transducers, collection cannulae, and infusion catheters to assess motility, intestinal flow and transit rates, and gastroduodenal emptying. Ten animals served to define normal parameters. Six animals underwent a 70% resection of the proximal small intestine to serve as short-gut controls. Six animals underwent removal of a 100-cm segment of the ileum, with cold storage, and autotransplantation the following day combined with a 70% resection of proximal bowel. Results. Transplant animals exhibited delayed gastroduodenal emptying, reduced intestinal flow rates, and postprandial phasic contractions that were similar to short-gut controls. However, transplant animals experienced rapid intestinal transit compared with short-gut controls (4.8 ± 0.4 cm/min vs 2.0 ± 0.3 cm/min; mean ± SEM; P < .05). Conclusions. The transplanted intestine, even with 18 hours of cold storage, exhibits a relatively normal postprandial motor response. However, adaptive responses of the transplanted intestine, such as regulation of intestine transit, may be impaired by neuromuscular injury associated with denervation or ischemia.

Original languageEnglish (US)
Pages (from-to)6-14
Number of pages9
JournalSurgery
Volume129
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Gastrointestinal Motility
Transplantation
Intestines
Transplants
Autologous Transplantation
Denervation
Transducers
Ileum
Small Intestine
Smooth Muscle
Canidae
Ischemia
Catheters
Wounds and Injuries

ASJC Scopus subject areas

  • Surgery

Cite this

Johnson, C. P., Sarna, S. K., Zhu, Y. R., Buchmann, E., Bonham, L., Telford, G. L., ... Adams, M. B. (2001). Effects of intestinal transplantation on postprandial motility and regulation of intestinal transit. Surgery, 129(1), 6-14. https://doi.org/10.1067/msy.2001.108612

Effects of intestinal transplantation on postprandial motility and regulation of intestinal transit. / Johnson, C. P.; Sarna, S. K.; Zhu, Y. R.; Buchmann, E.; Bonham, L.; Telford, G. L.; Roza, A. M.; Adams, M. B.

In: Surgery, Vol. 129, No. 1, 2001, p. 6-14.

Research output: Contribution to journalArticle

Johnson, CP, Sarna, SK, Zhu, YR, Buchmann, E, Bonham, L, Telford, GL, Roza, AM & Adams, MB 2001, 'Effects of intestinal transplantation on postprandial motility and regulation of intestinal transit', Surgery, vol. 129, no. 1, pp. 6-14. https://doi.org/10.1067/msy.2001.108612
Johnson, C. P. ; Sarna, S. K. ; Zhu, Y. R. ; Buchmann, E. ; Bonham, L. ; Telford, G. L. ; Roza, A. M. ; Adams, M. B. / Effects of intestinal transplantation on postprandial motility and regulation of intestinal transit. In: Surgery. 2001 ; Vol. 129, No. 1. pp. 6-14.
@article{5b8377a24cf447ec8ff6f3141a7a3c99,
title = "Effects of intestinal transplantation on postprandial motility and regulation of intestinal transit",
abstract = "Background. The effects of intestinal transplantation on gut motility have not been completely defined. In this study we examine the effects of ileal transplantation on ileal smooth muscle contractility, together with gastroduodenal emptying, intestinal flow, and transit rates in a canine model of short-gut syndrome. Methods. Animals (n = 22) were instrumented with strain gauge transducers, collection cannulae, and infusion catheters to assess motility, intestinal flow and transit rates, and gastroduodenal emptying. Ten animals served to define normal parameters. Six animals underwent a 70{\%} resection of the proximal small intestine to serve as short-gut controls. Six animals underwent removal of a 100-cm segment of the ileum, with cold storage, and autotransplantation the following day combined with a 70{\%} resection of proximal bowel. Results. Transplant animals exhibited delayed gastroduodenal emptying, reduced intestinal flow rates, and postprandial phasic contractions that were similar to short-gut controls. However, transplant animals experienced rapid intestinal transit compared with short-gut controls (4.8 ± 0.4 cm/min vs 2.0 ± 0.3 cm/min; mean ± SEM; P < .05). Conclusions. The transplanted intestine, even with 18 hours of cold storage, exhibits a relatively normal postprandial motor response. However, adaptive responses of the transplanted intestine, such as regulation of intestine transit, may be impaired by neuromuscular injury associated with denervation or ischemia.",
author = "Johnson, {C. P.} and Sarna, {S. K.} and Zhu, {Y. R.} and E. Buchmann and L. Bonham and Telford, {G. L.} and Roza, {A. M.} and Adams, {M. B.}",
year = "2001",
doi = "10.1067/msy.2001.108612",
language = "English (US)",
volume = "129",
pages = "6--14",
journal = "Surgery",
issn = "0039-6060",
publisher = "Mosby Inc.",
number = "1",

}

TY - JOUR

T1 - Effects of intestinal transplantation on postprandial motility and regulation of intestinal transit

AU - Johnson, C. P.

AU - Sarna, S. K.

AU - Zhu, Y. R.

AU - Buchmann, E.

AU - Bonham, L.

AU - Telford, G. L.

AU - Roza, A. M.

AU - Adams, M. B.

PY - 2001

Y1 - 2001

N2 - Background. The effects of intestinal transplantation on gut motility have not been completely defined. In this study we examine the effects of ileal transplantation on ileal smooth muscle contractility, together with gastroduodenal emptying, intestinal flow, and transit rates in a canine model of short-gut syndrome. Methods. Animals (n = 22) were instrumented with strain gauge transducers, collection cannulae, and infusion catheters to assess motility, intestinal flow and transit rates, and gastroduodenal emptying. Ten animals served to define normal parameters. Six animals underwent a 70% resection of the proximal small intestine to serve as short-gut controls. Six animals underwent removal of a 100-cm segment of the ileum, with cold storage, and autotransplantation the following day combined with a 70% resection of proximal bowel. Results. Transplant animals exhibited delayed gastroduodenal emptying, reduced intestinal flow rates, and postprandial phasic contractions that were similar to short-gut controls. However, transplant animals experienced rapid intestinal transit compared with short-gut controls (4.8 ± 0.4 cm/min vs 2.0 ± 0.3 cm/min; mean ± SEM; P < .05). Conclusions. The transplanted intestine, even with 18 hours of cold storage, exhibits a relatively normal postprandial motor response. However, adaptive responses of the transplanted intestine, such as regulation of intestine transit, may be impaired by neuromuscular injury associated with denervation or ischemia.

AB - Background. The effects of intestinal transplantation on gut motility have not been completely defined. In this study we examine the effects of ileal transplantation on ileal smooth muscle contractility, together with gastroduodenal emptying, intestinal flow, and transit rates in a canine model of short-gut syndrome. Methods. Animals (n = 22) were instrumented with strain gauge transducers, collection cannulae, and infusion catheters to assess motility, intestinal flow and transit rates, and gastroduodenal emptying. Ten animals served to define normal parameters. Six animals underwent a 70% resection of the proximal small intestine to serve as short-gut controls. Six animals underwent removal of a 100-cm segment of the ileum, with cold storage, and autotransplantation the following day combined with a 70% resection of proximal bowel. Results. Transplant animals exhibited delayed gastroduodenal emptying, reduced intestinal flow rates, and postprandial phasic contractions that were similar to short-gut controls. However, transplant animals experienced rapid intestinal transit compared with short-gut controls (4.8 ± 0.4 cm/min vs 2.0 ± 0.3 cm/min; mean ± SEM; P < .05). Conclusions. The transplanted intestine, even with 18 hours of cold storage, exhibits a relatively normal postprandial motor response. However, adaptive responses of the transplanted intestine, such as regulation of intestine transit, may be impaired by neuromuscular injury associated with denervation or ischemia.

UR - http://www.scopus.com/inward/record.url?scp=0035143453&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035143453&partnerID=8YFLogxK

U2 - 10.1067/msy.2001.108612

DO - 10.1067/msy.2001.108612

M3 - Article

VL - 129

SP - 6

EP - 14

JO - Surgery

JF - Surgery

SN - 0039-6060

IS - 1

ER -