Effects of intravascular transfusion for red cell alloimmunization on fetal arterial blood pressure

Linda A. Goodrum, Kenneth J. Moise, George Saade, Michael A. Belfort, Nancy A. Ayres, Robert J. Carpenter

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: To evaluate the effects of intravascular transfusion (IVT) on the fetal umbilical arterial pressure (UAP) in pregnancies complicated by red cell alloimmunization. Study Design: UAP and amniotic fluid pressures (AFP) were measured immediately before and after IVT. Mean UAP was calculated by computing 1/3 (systolic blood pressure - diastolic blood pressure) + diastolic blood pressure. The fractional increase in fetoplacental blood volume with transfusion was calculated by dividing the net volume of blood transfused by the sum of the net volume transfused and the fetoplacental volume based on the estimated fetal weight by ultrasound. Statistical techniques included paired t-test, and the Pearson product correlation. Significance was defined as p < 0.05. Results: The fetal umbilical artery was punctured during a total of 27 procedures in 21 patients. Pre- and posttransfusion mean UAPs were recorded in 16 of these procedures. Mean UAP increased from 34.0 ± 14.2 mmHg pretransfusion to 38.6 ± 12.8 mmHg posttransfusion (p = 0.34). There was no correlation between the fractional change in fetoplacental blood volume and the calculated difference between pre- and posttransfusion blood pressure. Bradycardia occurred during 5 procedures (31.2%). Fetal demise occurred after 2 procedures (12.5%). Conclusion: IVT appears to have a minimal effect on the fetal UAP. Fetal bradycardia occurs in a significant percentage of these cases.

Original languageEnglish (US)
Pages (from-to)149-152
Number of pages4
JournalFetal Diagnosis and Therapy
Volume12
Issue number3
StatePublished - 1997
Externally publishedYes

Fingerprint

Fetal Blood
Umbilicus
Arterial Pressure
Blood Pressure
Blood Volume
Bradycardia
Intrauterine Blood Transfusion
Fetal Weight
Umbilical Arteries
Fetal Death
Amniotic Fluid
Pressure
Pregnancy

Keywords

  • Intravascular transfusion
  • Red cell alloimmunization
  • Umbilical arterial blood pressure

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

Cite this

Goodrum, L. A., Moise, K. J., Saade, G., Belfort, M. A., Ayres, N. A., & Carpenter, R. J. (1997). Effects of intravascular transfusion for red cell alloimmunization on fetal arterial blood pressure. Fetal Diagnosis and Therapy, 12(3), 149-152.

Effects of intravascular transfusion for red cell alloimmunization on fetal arterial blood pressure. / Goodrum, Linda A.; Moise, Kenneth J.; Saade, George; Belfort, Michael A.; Ayres, Nancy A.; Carpenter, Robert J.

In: Fetal Diagnosis and Therapy, Vol. 12, No. 3, 1997, p. 149-152.

Research output: Contribution to journalArticle

Goodrum, LA, Moise, KJ, Saade, G, Belfort, MA, Ayres, NA & Carpenter, RJ 1997, 'Effects of intravascular transfusion for red cell alloimmunization on fetal arterial blood pressure', Fetal Diagnosis and Therapy, vol. 12, no. 3, pp. 149-152.
Goodrum, Linda A. ; Moise, Kenneth J. ; Saade, George ; Belfort, Michael A. ; Ayres, Nancy A. ; Carpenter, Robert J. / Effects of intravascular transfusion for red cell alloimmunization on fetal arterial blood pressure. In: Fetal Diagnosis and Therapy. 1997 ; Vol. 12, No. 3. pp. 149-152.
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