Effects of left ventricular support on right ventricular mechanics during experimental right ventricular ischemia

Marc R. Moon, Luis J. Castro, Abelardo DeAnda, George T. Daughters, Neil B. Ingels, D. Craig Miller

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background: Left ventricular (LV) assist device (LVAD) support has been associated with right ventricular (RV) failure in humans, but the etiology remains unknown. Mechanical LV support apparently does not induce RV pump failure in normal hearts, but controlled studies of LV assistance in hearts with preexistent RV dysfunction have been limited. Therefore, this study was performed to determine if LVAD support impairs RV systolic mechanics during acute RV ischemia. Methods and Results: Five closed-chest, autonomically blocked, sedated dogs were studied after placement of an LVAD (LV-femoral artery bypass), right coronary artery (RCA) occluder, and 27 miniature radiopaque tantalum markers into the LV and RV walls for independent computation of RV and LV volumes. Biplane videofluoroscopic marker images and hemodynamic data were recorded before RCA occlusion with the LVAD off (maximum LV pressure [LVP(max)] = 119±25 mm Hg), after 3 minutes of RCA occlusion with the LVAD off (LVP(max)=84±18 mm Hg), and then with the LVAD on (LVP(max)=26±32 mm Hg). Global RV contractility (end-systolic elastance [RV E(es)] and preload recruitable stroke work [RV PRSW]), RV power output, and the mechanical (pump) efficiency of converting potential energy to external work (ratio of RV stroke work/total pressure-volume area) were calculated. As expected, with RCA occlusion there were major decreases in RV E(es) (from 2.5±1.2 to 1.4±0.5 mm Hg/mL, P.80). Pulmonary artery input impedance (RV afterload) decreased from 848±628 to 673±577 dyne · sec-1 · cm-1 (P

Original languageEnglish (US)
JournalCirculation
Volume90
Issue number5 II
StatePublished - Nov 1994
Externally publishedYes

Fingerprint

Mechanics
Coronary Occlusion
Ischemia
Equipment and Supplies
Coronary Vessels
Heart-Assist Devices
Stroke
Tantalum
Right Ventricular Dysfunction
Ventricular Pressure
Femoral Artery
Electric Impedance
Coronary Artery Bypass
Pulmonary Artery
Thorax
Hemodynamics
Dogs
Pressure

Keywords

  • heart failure
  • ischemia
  • mechanics
  • ventricles

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Moon, M. R., Castro, L. J., DeAnda, A., Daughters, G. T., Ingels, N. B., & Miller, D. C. (1994). Effects of left ventricular support on right ventricular mechanics during experimental right ventricular ischemia. Circulation, 90(5 II).

Effects of left ventricular support on right ventricular mechanics during experimental right ventricular ischemia. / Moon, Marc R.; Castro, Luis J.; DeAnda, Abelardo; Daughters, George T.; Ingels, Neil B.; Miller, D. Craig.

In: Circulation, Vol. 90, No. 5 II, 11.1994.

Research output: Contribution to journalArticle

Moon, MR, Castro, LJ, DeAnda, A, Daughters, GT, Ingels, NB & Miller, DC 1994, 'Effects of left ventricular support on right ventricular mechanics during experimental right ventricular ischemia', Circulation, vol. 90, no. 5 II.
Moon, Marc R. ; Castro, Luis J. ; DeAnda, Abelardo ; Daughters, George T. ; Ingels, Neil B. ; Miller, D. Craig. / Effects of left ventricular support on right ventricular mechanics during experimental right ventricular ischemia. In: Circulation. 1994 ; Vol. 90, No. 5 II.
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