Effects of long-term oxandrolone administration in severely burned children

Kevin D. Murphy, Suchmor Thomas, Ronald P. Mlcak, David L. Chinkes, Gordon L. Klein, David Herndon

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Background Severe burns cause exaggerated catabolism of muscle protein and inhibit bone deposition. Weakness and bony growth arrest interfere with rehabilitation. The purpose of this study was to determine whether oxandrolone administration for 1 year after the burn reverses muscle and bone catabolism in hypermetabolic pediatric burn patients. Methods Children with burns greater than 40% total body surface area were enrolled into a randomized controlled trial to receive oxandrolone as a long-term anabolic agent. All patients received similar clinical care. Subjects were studied at discharge (95% healed) and at 6, 9, and 12 months after the burn, after treatment with 0.1 mg/kg po bid or placebo. Serum hepatic transaminases were measured. Lean body mass (LBM), bone mineral content (BMC,) and bone mineral density (BMD) were measured by dual energy x-ray absorptiometry. Patients completed a safety questionnaire and were reviewed clinically at intervals. Results The groups were similar in age, weight, and total body surface area burned. LBM was significantly greater with oxandrolone at 6, 9, and 12 months after the burn (P < .001) and BMC at 12 months (P < .016). Age- and gender-matched BMD z scores were significantly better with oxandrolone (P < .039). Liver transaminases were unaffected. Conclusions Long-term administration of oxandrolone safely improves LBM, BMC, and BMD in severely burned children.

Original languageEnglish (US)
Pages (from-to)219-224
Number of pages6
JournalSurgery
Volume136
Issue number2
DOIs
StatePublished - Aug 2004

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Oxandrolone
Bone Density
Body Surface Area
Transaminases
Burns
Anabolic Agents
Bone and Bones
Muscle Proteins
Liver
Rehabilitation
Randomized Controlled Trials
Placebos
X-Rays
Pediatrics
Safety
Weights and Measures
Muscles
Growth
Serum

ASJC Scopus subject areas

  • Surgery

Cite this

Murphy, K. D., Thomas, S., Mlcak, R. P., Chinkes, D. L., Klein, G. L., & Herndon, D. (2004). Effects of long-term oxandrolone administration in severely burned children. Surgery, 136(2), 219-224. https://doi.org/10.1016/j.surg.2004.04.022

Effects of long-term oxandrolone administration in severely burned children. / Murphy, Kevin D.; Thomas, Suchmor; Mlcak, Ronald P.; Chinkes, David L.; Klein, Gordon L.; Herndon, David.

In: Surgery, Vol. 136, No. 2, 08.2004, p. 219-224.

Research output: Contribution to journalArticle

Murphy, KD, Thomas, S, Mlcak, RP, Chinkes, DL, Klein, GL & Herndon, D 2004, 'Effects of long-term oxandrolone administration in severely burned children', Surgery, vol. 136, no. 2, pp. 219-224. https://doi.org/10.1016/j.surg.2004.04.022
Murphy KD, Thomas S, Mlcak RP, Chinkes DL, Klein GL, Herndon D. Effects of long-term oxandrolone administration in severely burned children. Surgery. 2004 Aug;136(2):219-224. https://doi.org/10.1016/j.surg.2004.04.022
Murphy, Kevin D. ; Thomas, Suchmor ; Mlcak, Ronald P. ; Chinkes, David L. ; Klein, Gordon L. ; Herndon, David. / Effects of long-term oxandrolone administration in severely burned children. In: Surgery. 2004 ; Vol. 136, No. 2. pp. 219-224.
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AB - Background Severe burns cause exaggerated catabolism of muscle protein and inhibit bone deposition. Weakness and bony growth arrest interfere with rehabilitation. The purpose of this study was to determine whether oxandrolone administration for 1 year after the burn reverses muscle and bone catabolism in hypermetabolic pediatric burn patients. Methods Children with burns greater than 40% total body surface area were enrolled into a randomized controlled trial to receive oxandrolone as a long-term anabolic agent. All patients received similar clinical care. Subjects were studied at discharge (95% healed) and at 6, 9, and 12 months after the burn, after treatment with 0.1 mg/kg po bid or placebo. Serum hepatic transaminases were measured. Lean body mass (LBM), bone mineral content (BMC,) and bone mineral density (BMD) were measured by dual energy x-ray absorptiometry. Patients completed a safety questionnaire and were reviewed clinically at intervals. Results The groups were similar in age, weight, and total body surface area burned. LBM was significantly greater with oxandrolone at 6, 9, and 12 months after the burn (P < .001) and BMC at 12 months (P < .016). Age- and gender-matched BMD z scores were significantly better with oxandrolone (P < .039). Liver transaminases were unaffected. Conclusions Long-term administration of oxandrolone safely improves LBM, BMC, and BMD in severely burned children.

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