Abstract
There is evidence of increased oxygen free radical activity after smoke inhalation with and without concomitant burn injury. We determined the effects of manganese super-oxide dismutase (Mn SOD) on lung fluid balance as measured by lung microvascular permeability coefficient (σ), filtration coefficient (K(f)), and lymph flow. Merino breed ewes (n = 6/group) were surgically prepared. The SOD group (SOD) received Mn SOD (9,000 U/kg) as an intravenous bolus and was insufflated with smoke. The control group (CON) received saline and smoke. σ and K(f) were determined 24 h before and 24 h after smoke injury. Lymph flow, arterial O2-to-inspired O2 fraction ratio, systemic hemodynamics, and pulmonary arterial and capillary pressures were measured. The σ was significantly (P < 0.05) higher after smoke insufflation in SOD compared with CON (0.71 ± 0.03 vs. 0.53 ± 0.05). K(f) was significantly lower after smoke insufflation in SOD compared with CON (0.038 ± 0.010 vs. 0.061 ± 0.010). Lymph flows were significantly lower during the 24 h after smoke insufflation in SOD compared with CON (33 ± 7 vs. 55 ± 8 ml/h at 24 h). Arterial O2-to-inspired O2 fraction ratio was significantly improved at 6 and 12 h after smoke insufflation in SOD compared with CON at the same time points. Mn SOD meliorates the lung microvascular permeability changes associated with smoke inhalation injury.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2161-2168 |
| Number of pages | 8 |
| Journal | Journal of Applied Physiology |
| Volume | 78 |
| Issue number | 6 |
| State | Published - 1995 |
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Keywords
- acute lung injury
- burn inhalation
- burns
- filtration coefficient
- lung lymphatic
- oxygen radicals
- pulmonary
- reflection coefficient
- sheep
ASJC Scopus subject areas
- Endocrinology
- Physiology
- Orthopedics and Sports Medicine
- Physical Therapy, Sports Therapy and Rehabilitation
Cite this
Effects of manganese superoxide dismutase on lung fluid balance after smoke inhalation. / Nguyen, T. T.; Cox, C. S.; Herndon, David; Biondo, N. A.; Traber, L. D.; Bush, P. E.; Zophel, A.; Traber, D. L.
In: Journal of Applied Physiology, Vol. 78, No. 6, 1995, p. 2161-2168.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of manganese superoxide dismutase on lung fluid balance after smoke inhalation
AU - Nguyen, T. T.
AU - Cox, C. S.
AU - Herndon, David
AU - Biondo, N. A.
AU - Traber, L. D.
AU - Bush, P. E.
AU - Zophel, A.
AU - Traber, D. L.
PY - 1995
Y1 - 1995
N2 - There is evidence of increased oxygen free radical activity after smoke inhalation with and without concomitant burn injury. We determined the effects of manganese super-oxide dismutase (Mn SOD) on lung fluid balance as measured by lung microvascular permeability coefficient (σ), filtration coefficient (K(f)), and lymph flow. Merino breed ewes (n = 6/group) were surgically prepared. The SOD group (SOD) received Mn SOD (9,000 U/kg) as an intravenous bolus and was insufflated with smoke. The control group (CON) received saline and smoke. σ and K(f) were determined 24 h before and 24 h after smoke injury. Lymph flow, arterial O2-to-inspired O2 fraction ratio, systemic hemodynamics, and pulmonary arterial and capillary pressures were measured. The σ was significantly (P < 0.05) higher after smoke insufflation in SOD compared with CON (0.71 ± 0.03 vs. 0.53 ± 0.05). K(f) was significantly lower after smoke insufflation in SOD compared with CON (0.038 ± 0.010 vs. 0.061 ± 0.010). Lymph flows were significantly lower during the 24 h after smoke insufflation in SOD compared with CON (33 ± 7 vs. 55 ± 8 ml/h at 24 h). Arterial O2-to-inspired O2 fraction ratio was significantly improved at 6 and 12 h after smoke insufflation in SOD compared with CON at the same time points. Mn SOD meliorates the lung microvascular permeability changes associated with smoke inhalation injury.
AB - There is evidence of increased oxygen free radical activity after smoke inhalation with and without concomitant burn injury. We determined the effects of manganese super-oxide dismutase (Mn SOD) on lung fluid balance as measured by lung microvascular permeability coefficient (σ), filtration coefficient (K(f)), and lymph flow. Merino breed ewes (n = 6/group) were surgically prepared. The SOD group (SOD) received Mn SOD (9,000 U/kg) as an intravenous bolus and was insufflated with smoke. The control group (CON) received saline and smoke. σ and K(f) were determined 24 h before and 24 h after smoke injury. Lymph flow, arterial O2-to-inspired O2 fraction ratio, systemic hemodynamics, and pulmonary arterial and capillary pressures were measured. The σ was significantly (P < 0.05) higher after smoke insufflation in SOD compared with CON (0.71 ± 0.03 vs. 0.53 ± 0.05). K(f) was significantly lower after smoke insufflation in SOD compared with CON (0.038 ± 0.010 vs. 0.061 ± 0.010). Lymph flows were significantly lower during the 24 h after smoke insufflation in SOD compared with CON (33 ± 7 vs. 55 ± 8 ml/h at 24 h). Arterial O2-to-inspired O2 fraction ratio was significantly improved at 6 and 12 h after smoke insufflation in SOD compared with CON at the same time points. Mn SOD meliorates the lung microvascular permeability changes associated with smoke inhalation injury.
KW - acute lung injury
KW - burn inhalation
KW - burns
KW - filtration coefficient
KW - lung lymphatic
KW - oxygen radicals
KW - pulmonary
KW - reflection coefficient
KW - sheep
UR - http://www.scopus.com/inward/record.url?scp=0029055850&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029055850&partnerID=8YFLogxK
M3 - Article
C2 - 7665413
AN - SCOPUS:0029055850
VL - 78
SP - 2161
EP - 2168
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
SN - 8750-7587
IS - 6
ER -