Effects of manganese superoxide dismutase on lung fluid balance after smoke inhalation

T. T. Nguyen, C. S. Cox, David Herndon, N. A. Biondo, L. D. Traber, P. E. Bush, A. Zophel, D. L. Traber

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

There is evidence of increased oxygen free radical activity after smoke inhalation with and without concomitant burn injury. We determined the effects of manganese super-oxide dismutase (Mn SOD) on lung fluid balance as measured by lung microvascular permeability coefficient (σ), filtration coefficient (K(f)), and lymph flow. Merino breed ewes (n = 6/group) were surgically prepared. The SOD group (SOD) received Mn SOD (9,000 U/kg) as an intravenous bolus and was insufflated with smoke. The control group (CON) received saline and smoke. σ and K(f) were determined 24 h before and 24 h after smoke injury. Lymph flow, arterial O2-to-inspired O2 fraction ratio, systemic hemodynamics, and pulmonary arterial and capillary pressures were measured. The σ was significantly (P < 0.05) higher after smoke insufflation in SOD compared with CON (0.71 ± 0.03 vs. 0.53 ± 0.05). K(f) was significantly lower after smoke insufflation in SOD compared with CON (0.038 ± 0.010 vs. 0.061 ± 0.010). Lymph flows were significantly lower during the 24 h after smoke insufflation in SOD compared with CON (33 ± 7 vs. 55 ± 8 ml/h at 24 h). Arterial O2-to-inspired O2 fraction ratio was significantly improved at 6 and 12 h after smoke insufflation in SOD compared with CON at the same time points. Mn SOD meliorates the lung microvascular permeability changes associated with smoke inhalation injury.

Original languageEnglish (US)
Pages (from-to)2161-2168
Number of pages8
JournalJournal of Applied Physiology
Volume78
Issue number6
StatePublished - 1995

Fingerprint

Water-Electrolyte Balance
Smoke
Inhalation
Superoxide Dismutase
Lung
Insufflation
Lymph
Control Groups
Capillary Permeability
Smoke Inhalation Injury
Wounds and Injuries
Free Radicals
Reactive Oxygen Species
Arterial Pressure
Hemodynamics

Keywords

  • acute lung injury
  • burn inhalation
  • burns
  • filtration coefficient
  • lung lymphatic
  • oxygen radicals
  • pulmonary
  • reflection coefficient
  • sheep

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Nguyen, T. T., Cox, C. S., Herndon, D., Biondo, N. A., Traber, L. D., Bush, P. E., ... Traber, D. L. (1995). Effects of manganese superoxide dismutase on lung fluid balance after smoke inhalation. Journal of Applied Physiology, 78(6), 2161-2168.

Effects of manganese superoxide dismutase on lung fluid balance after smoke inhalation. / Nguyen, T. T.; Cox, C. S.; Herndon, David; Biondo, N. A.; Traber, L. D.; Bush, P. E.; Zophel, A.; Traber, D. L.

In: Journal of Applied Physiology, Vol. 78, No. 6, 1995, p. 2161-2168.

Research output: Contribution to journalArticle

Nguyen, TT, Cox, CS, Herndon, D, Biondo, NA, Traber, LD, Bush, PE, Zophel, A & Traber, DL 1995, 'Effects of manganese superoxide dismutase on lung fluid balance after smoke inhalation', Journal of Applied Physiology, vol. 78, no. 6, pp. 2161-2168.
Nguyen TT, Cox CS, Herndon D, Biondo NA, Traber LD, Bush PE et al. Effects of manganese superoxide dismutase on lung fluid balance after smoke inhalation. Journal of Applied Physiology. 1995;78(6):2161-2168.
Nguyen, T. T. ; Cox, C. S. ; Herndon, David ; Biondo, N. A. ; Traber, L. D. ; Bush, P. E. ; Zophel, A. ; Traber, D. L. / Effects of manganese superoxide dismutase on lung fluid balance after smoke inhalation. In: Journal of Applied Physiology. 1995 ; Vol. 78, No. 6. pp. 2161-2168.
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